INT2270

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Context Info
Confidence 0.21
First Reported 1979
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 4.23
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (F2) peptidase activity (F2) extracellular space (F2)
extracellular region (F2) response to stress (F2)
Anatomy Link Frequency
blood 2
skin 2
F2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 15 99.80 Very High Very High Very High
diclofenac 6 92.68 High High
withdrawal 21 90.44 High High
Analgesic 1 84.12 Quite High
abdominal pain 2 81.72 Quite High
cINOD 1 80.88 Quite High
visual analogue scale 1 80.40 Quite High
aspirin 5 71.92 Quite High
cva 14 65.40 Quite High
Bioavailability 3 64.48 Quite High
Disease Link Frequency Relevance Heat
Thrombocytopenia 1 99.90 Very High Very High Very High
Pain 12 99.80 Very High Very High Very High
Infection 2 99.60 Very High Very High Very High
Coagulation Disorder 43 99.54 Very High Very High Very High
Herpes Zoster 6 99.16 Very High Very High Very High
Hemorrhage 111 97.84 Very High Very High Very High
Colitis 1 96.04 Very High Very High Very High
Hemorrhagic Diathesis 1 95.04 Very High Very High Very High
Pressure And Volume Under Development 8 91.68 High High
Lymphadenopathy 1 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mortality was high (four of seven patients, 57 percent) and characterized by comparatively longer patient histories of colitis, longer current attacks, slightly greater delays between presumed perforation and operation, much higher transfusion requirements, and a 100 percent incidence of coagulopathy (thrombocytopenia and increased prothrombin time in three of four patients, and increased partial thromboplastin time in all four patients).
Positive_regulation (increased) of Gene_expression (time) of prothrombin associated with colitis, coagulation disorder and thrombocytopenia
1) Confidence 0.21 Published 1986 Journal Am. J. Surg. Section Abstract Doc Link 3752375 Disease Relevance 0.74 Pain Relevance 0.08
In the first case a 12 year old boy, who after the removal of the pressure immobilisation bandage, developed decreased fibrinogen levels and positive cross-linked fibrinogen degradation products (XDPs), but normal prothrombin time and activated partial prothrombin time.
Spec (partial) Positive_regulation (activated) of Spec (partial) Gene_expression (time) of prothrombin
2) Confidence 0.21 Published 2002 Journal Toxicon Section Abstract Doc Link 11711130 Disease Relevance 0.52 Pain Relevance 0.09
Although it produces minimal increases in prothrombin and partial thromboplastin times in healthy volunteers, it does not significantly affect the individual clotting factors, nor does it, in patients, enhance the effect of acenocoumarol or phenprocoumon.
Spec (partial) Positive_regulation (increases) of Gene_expression (produces) of prothrombin associated with coagulation disorder
3) Confidence 0.08 Published 1979 Journal Rheumatol Rehabil Section Abstract Doc Link 394276 Disease Relevance 0.23 Pain Relevance 0.39
However, topical hemostatic agents may have disadvantages, such as limited efficacy, limited availability, limited vascular biological compatibility, expensiveness, and risk of infection as a result of the requirement for human blood for commercial production of collagen, thrombin, and prothrombin [6].
Positive_regulation (requirement) of Gene_expression (production) of prothrombin in blood associated with infection
4) Confidence 0.07 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2993704 Disease Relevance 0.35 Pain Relevance 0.03
Up-regulation of prothrombin expression by the vascular endothelial and sweat gland epithelial cells in the active skin lesion and transient elevation of plasma thrombin-antithrombin III complex levels in a proportion of patients suggest a lesional generation of thrombin in herpes zoster.
Positive_regulation (regulation) of Gene_expression (expression) of prothrombin in skin associated with herpes zoster
5) Confidence 0.06 Published 2001 Journal J. Dermatol. Section Abstract Doc Link 11449671 Disease Relevance 0.89 Pain Relevance 0.60
preoperative prothrombin time was significantly higher, preoperative albumin
Positive_regulation (preoperative) of Gene_expression (time) of prothrombin
6) Confidence 0.04 Published 1999 Journal Crit Care Section Body Doc Link PMC29029 Disease Relevance 0.65 Pain Relevance 0
Bleeding episodes in patients with high responding inhibitor levels pose a considerable challenge to clinicians and requires the use of bypassing agents such as prothrombin complexes and recombinant activated factor VIIa (rFVIIa, Novo Seven).
Positive_regulation (requires) of Gene_expression (complexes) of prothrombin associated with hemorrhage
7) Confidence 0.03 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994012 Disease Relevance 0.66 Pain Relevance 0.03
With this new pill the levels of high density lipoprotein increased, while the levels of prothrombin fragment 1 + 2 and D-dimer remained relatively unchanged; the levels of sex hormone binding globulin, cortisol binding globulin, thyroxine binding globulin increased.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (levels) of prothrombin
8) Confidence 0.01 Published 2010 Journal International Journal of Women's Health Section Abstract Doc Link PMC2990895 Disease Relevance 0.19 Pain Relevance 0.05

General Comments

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