INT22700

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 6.89
Pain Relevance 8.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
dorsal horn 4
Peripheral nerve 4
rectum 3
nucleus accumbens 3
AMs 2
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 170 100.00 Very High Very High Very High
Dorsal horn 12 100.00 Very High Very High Very High
neuralgia 3 100.00 Very High Very High Very High
Nucleus accumbens 7 99.96 Very High Very High Very High
Inflammation 323 99.90 Very High Very High Very High
Hyperesthesia 3 99.90 Very High Very High Very High
Neuropathic pain 3 99.76 Very High Very High Very High
Enkephalin 6 99.42 Very High Very High Very High
Peripheral nerve injury 6 99.24 Very High Very High Very High
dorsal root ganglion 7 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 313 99.90 Very High Very High Very High
Hyperaesthesia 3 99.90 Very High Very High Very High
Neuropathic Pain 10 99.76 Very High Very High Very High
Hypersensitivity 21 99.64 Very High Very High Very High
Nociception 5 99.44 Very High Very High Very High
Nervous System Injury 14 99.24 Very High Very High Very High
Ganglion Cysts 12 98.72 Very High Very High Very High
Inflammatory Bowel Disease 194 97.56 Very High Very High Very High
Disease 83 96.44 Very High Very High Very High
Neurogenic Inflammation 18 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peripheral nerve injury is associated with hyperesthesia and increased neurokinin-1 receptor (NK-1) expression in the dorsal horn of the spinal cord.
Positive_regulation (increased) of Gene_expression (expression) of NK-1 in Peripheral nerve associated with hyperesthesia, nervous system injury, dorsal horn, spinal cord and peripheral nerve injury
1) Confidence 0.69 Published 2004 Journal J Pain Section Abstract Doc Link 15042514 Disease Relevance 0.42 Pain Relevance 0.64
Neurokinin-1 receptor gene expression in the mouse dorsal horn increases with neuropathic pain.
Positive_regulation (increases) of Gene_expression (expression) of Neurokinin-1 receptor in dorsal horn associated with neuralgia, neuropathic pain and dorsal horn
2) Confidence 0.50 Published 2004 Journal J Pain Section Title Doc Link 15042514 Disease Relevance 0.71 Pain Relevance 0.97
Peripheral nerve injury is associated with hyperesthesia and increased neurokinin-1 receptor (NK-1) expression in the dorsal horn of the spinal cord.
Positive_regulation (increased) of Gene_expression (expression) of neurokinin-1 receptor in Peripheral nerve associated with hyperesthesia, nervous system injury, dorsal horn, spinal cord and peripheral nerve injury
3) Confidence 0.50 Published 2004 Journal J Pain Section Abstract Doc Link 15042514 Disease Relevance 0.42 Pain Relevance 0.64
mediates the inhibitory effect of E2 (after 24 h) on Tac1 expression.
Positive_regulation (mediates) of Gene_expression (expression) of Tac1
4) Confidence 0.45 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.15
Tac1 expression was increased 3-fold in uterine cDNA from mice treated with E2 for 3 h, compared with vehicle-treated (3 h) mice (Fig. 1A).
Positive_regulation (increased) of Gene_expression (expression) of Tac1 in uterine
5) Confidence 0.45 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
In the striatum and nucleus accumbens, expression of PPT mRNA was elevated but PPE-A mRNA, D-1, D-2 receptor, and nNOS mRNA were not changed in hph-1 mice compared to controls.
Positive_regulation (elevated) of Gene_expression (expression) of PPT in nucleus accumbens associated with nucleus accumbens
6) Confidence 0.40 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.33 Pain Relevance 0.58
Taken together with previous observations that noxious stimuli increase preprotachykinin expression in ascending nociceptive pathways from the spinal dorsal horn, the present finding provides evidence that substance P is involved in nociceptive processing also in the brain stem.
Positive_regulation (increase) of Gene_expression (expression) of preprotachykinin in dorsal horn associated with nociception, spinal dorsal horn and substance p
7) Confidence 0.39 Published 1995 Journal Neuroreport Section Abstract Doc Link 7541653 Disease Relevance 0.27 Pain Relevance 0.42
This study was conducted to determine whether Na(v)1.8 contributes to the release and/or synthesis of substance P (SP) in adult mice dorsal root ganglion (DRG) neurons.
Spec (whether) Positive_regulation (contributes) of Gene_expression (synthesis) of substance P in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and substance p
8) Confidence 0.22 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18845912 Disease Relevance 0.86 Pain Relevance 0.71
Neurokinin 1 receptors (NK1Rs) in alveolar macrophages (AMs) are overexpressed by cigarette smoke (CS) in vivo and substance P (SP) in vitro.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of substance P in AMs associated with substance p
9) Confidence 0.15 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.46
In the striatum and nucleus accumbens, expression of PPT mRNA was elevated but PPE-A mRNA, D-1, D-2 receptor, and nNOS mRNA were not changed in hph-1 mice compared to controls.
Positive_regulation (elevated) of in striatum Gene_expression (expression) of PPT in nucleus accumbens associated with nucleus accumbens
10) Confidence 0.14 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.33 Pain Relevance 0.58
Elevated SP and upregulated NK-1 receptor expression have been reported in the rectum and colon of patients with IBD [42].
Positive_regulation (upregulated) of Gene_expression (expression) of NK-1 in rectum associated with inflammatory bowel disease and substance p
11) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.06 Pain Relevance 0.63
Chronic naltrexone treatment increases expression of preproenkephalin and preprotachykinin mRNA in discrete brain regions.
Positive_regulation (increases) of Gene_expression (expression) of preprotachykinin mRNA in brain associated with enkephalin
12) Confidence 0.09 Published 1990 Journal J. Neurosci. Section Title Doc Link 2319301 Disease Relevance 0.06 Pain Relevance 0.76
Several investigators have discussed the increased in vivo expression of NK1 receptor in inflamed tissue [56,57].
Positive_regulation (increased) of Gene_expression (expression) of NK1
13) Confidence 0.04 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.26 Pain Relevance 0.49
However, when stimulated by IgE receptor cross-linking, these mast cells started to express NK1 receptors but not NK2 or NK3 receptors, again suggesting that specific tissue conditions such as allergic inflammation may lead to mast cell expression of NK1 receptors.


Spec (may) Positive_regulation (lead) of Gene_expression (expression) of NK1 in mast cell associated with inflammation and hypersensitivity
14) Confidence 0.04 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.20 Pain Relevance 0.24
Elevated SP and upregulated NK-1 receptor expression have been reported in the rectum and colon of patients with IBD [42].
Positive_regulation (upregulated) of in colon Gene_expression (expression) of NK-1 in rectum associated with inflammatory bowel disease and substance p
15) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.06 Pain Relevance 0.63
Increased expression or release of Substance-P following neurotrophic stimulation of cells has been described in diverse settings documenting its important role in the hematopoietic-neuro-immune axis in inflammation, as well as normal and malignant hematopoiesis[57]–[62].
Positive_regulation (Increased) of Gene_expression (expression) of Substance-P associated with hematological disease, malignant neoplastic disease and inflammation
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.91 Pain Relevance 0.28

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