INT227017

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 16
Disease Relevance 14.84
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (KRT17)
Anatomy Link Frequency
skin 3
hair follicle 1
medulla 1
sebaceous gland 1
Merkel cell 1
KRT17 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 91 99.18 Very High Very High Very High
medulla 105 96.68 Very High Very High Very High
Bile 15 5.00 Very Low Very Low Very Low
Chronic pancreatitis 15 5.00 Very Low Very Low Very Low
Potency 15 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1313 100.00 Very High Very High Very High
Breast Cancer 221 99.96 Very High Very High Very High
Adenocarcinoma 690 99.84 Very High Very High Very High
Cervical Intraepithelial Neoplasia 15 99.84 Very High Very High Very High
Injury 180 99.44 Very High Very High Very High
Frailty 15 99.40 Very High Very High Very High
INFLAMMATION 75 99.18 Very High Very High Very High
Apoptosis 165 98.60 Very High Very High Very High
Cyst 30 97.92 Very High Very High Very High
Wound Healing 60 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among adenocarcinomas, focal K17 expression seems to be particularly characteristic of pancreatic ductal adenocarcinomas (Real et al. 1993; Moll 1998), which may become useful for their distinction from other adenocarcinomas (Chu and Weiss 2002b).
Gene_expression (expression) of K17 associated with adenocarcinoma
1) Confidence 0.45 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.27 Pain Relevance 0.04
The aforementioned expression of K17 in the pilosebaceous tract (in the follicular outer root sheath, companion layer, medulla and sebaceous gland; for review, see Langbein and Schweizer 2005) has also proven to be functionally relevant.
Gene_expression (expression) of K17 in medulla associated with medulla
2) Confidence 0.45 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.87 Pain Relevance 0.05
In the uterine cervix, K17 is expressed in cervical intraepithelial neoplasia but since it is already present in endocervical reserve cells (Weikel et al. 1987) and immature squamous metaplasia, it has not yet become a routine diagnostic marker (Martens et al. 1999).
Gene_expression (expressed) of K17 in uterine cervix associated with metaplasia and cervical intraepithelial neoplasia
3) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.35 Pain Relevance 0.04
Ductal adenocarcinomas of the pancreas in addition often express certain stratified-epithelial keratins, most notably K4 and K17 (Schüssler et al. 1992; Real et al. 1993; Moll 1998).
Gene_expression (express) of K17 in pancreas associated with adenocarcinoma
4) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.04 Pain Relevance 0
These genodermatoses obviously are related to the expression and functional importance of K17 in pilosebaceous and nail (Perrin et al. 2004; Langbein and Schweizer 2005) epithelia.
Gene_expression (expression) of K17 in nail
5) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.17 Pain Relevance 0.07
In ductal breast carcinomas, K17 is expressed in a minor subset of tumor cases (Malzahn et al. 1998), now recognized to correspond to the basal-like subtype as defined by global gene expression data (see below, chapter “Keratins as diagnostic markers in tumor pathology”).


Gene_expression (expressed) of K17 associated with cancer and breast cancer
6) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.14 Pain Relevance 0.03
The type I keratin K17 was identified in our early gel electrophoretic studies as a major keratin of basal cell carcinomas of the skin which was also present in the normal pilosebaceous tract but not in normal epidermis (Moll et al. 1982c).
Gene_expression (The) of K17 in skin associated with basal cell carcinoma
7) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.01 Pain Relevance 0
The type I keratin K17 was identified in our early gel electrophoretic studies as a major keratin of basal cell carcinomas of the skin which was also present in the normal pilosebaceous tract but not in normal epidermis (Moll et al. 1982c).
Gene_expression (identified) of K17 in skin associated with basal cell carcinoma
8) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.00 Pain Relevance 0
Most of these tumors strongly express the keratins K5 (Fig. 4c, e), K14 and K17 normally found in the basal layer as well as the keratins K6 (Fig. 4d) and K16 characteristic for hyperproliferative keratinocytes.
Gene_expression (express) of K17 in keratinocytes associated with cancer
9) Confidence 0.35 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.12 Pain Relevance 0
Another interesting feature of K17 is its inducibility after skin injury: after K6/K16 (see above), K17 is switched on in regenerating and migrating epidermal keratinocytes upon wound healing (Paladini et al. 1996).
Gene_expression (switched) of K17 in skin associated with wound healing and injury
10) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.53 Pain Relevance 0.03
Upon various types of injury such as inflammation or atrophy these cells may additionally switch on K7 and K19, sometimes also K17 (as well as vimentin) and thus express four to five instead of two keratins (Moll et al. 1991).
Gene_expression (switch) of K17 associated with inflammation, frailty and injury
11) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.45 Pain Relevance 0.05
The same group later showed that K17 modulates hair follicle cycling by delaying apoptosis, whereby K17 is functionally linked with TNF?
Gene_expression (modulates) of K17 in hair follicle associated with apoptosis
12) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.10 Pain Relevance 0.04
Immunohistochemistry also confirmed the essential absence of K17 from adult interfollicular epidermis, but, interestingly, revealed its specific expression in the specialized epidermal keratinocytes of the sensory Merkel cell-associated “haarscheiben” organs (Moll et al. 1993a); this keratin thus may be applied as a sensitive haarscheiben marker in studies of cutaneous neurobiology.
Gene_expression (expression) of K17 in Merkel cell
13) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.18 Pain Relevance 0
WalBC cells exhibited expression of known markers of basal invasive human breast cancers as well as increased KRT17, KRT 14 and KRT 19, DSP, s100A4, NDRG-1, ANXA1, TK1 and AQP3 gene expression and decreased gene expression of TIMP3, VIM and TAGLN.
Gene_expression (expression) of KRT17 associated with breast cancer
14) Confidence 0.27 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2263075 Disease Relevance 0.87 Pain Relevance 0
Interestingly, the typical expression profile of the basal-like cancers includes the basal cell-typical keratins K5, K14 and K17.
Gene_expression (expression) of K17 in basal cell associated with cancer
15) Confidence 0.15 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.89 Pain Relevance 0
The aforementioned expression of K17 in the pilosebaceous tract (in the follicular outer root sheath, companion layer, medulla and sebaceous gland; for review, see Langbein and Schweizer 2005) has also proven to be functionally relevant.
Gene_expression (expression) of K17 in sebaceous gland associated with medulla
16) Confidence 0.15 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.87 Pain Relevance 0.05

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