INT227040

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.67
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CHRM2) signal transducer activity (CHRM2)
Anatomy Link Frequency
neuronal 1
smooth muscle 1
parasympathetic 1
eosinophils 1
heart 1
CHRM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 94.96 High High
Inflammation 41 57.88 Quite High
agonist 8 36.68 Quite Low
anesthesia 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
noradrenaline 4 5.00 Very Low Very Low Very Low
guanethidine 4 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 32 99.50 Very High Very High Very High
Asthma 170 96.48 Very High Very High Very High
Viral Infection 20 89.00 High High
Eosinophilia 4 83.60 Quite High
INFLAMMATION 41 57.88 Quite High
Pulmonary Disease 56 45.12 Quite Low
Neuroblastoma 4 38.48 Quite Low
Disease 10 32.60 Quite Low
Obstructive Airway Disease 1 17.84 Low Low
Nicotine Addiction 3 13.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, antagonism of the M1 and M3 receptors reduce smooth muscle tone and cause beneficial bronchodilation while inhibition of the M2 receptor has the opposite effect.
Negative_regulation (inhibition) of M2 receptor in smooth muscle
1) Confidence 0.14 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695619 Disease Relevance 0 Pain Relevance 0.03
This parathion-mediated shift in vagally induced bradycardia may be due to selective loss of neuronal M2 muscarinic receptor function on parasympathetic nerves supplying the heart.
Negative_regulation (loss) of M2 muscarinic receptor in heart associated with heart rate under development
2) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265045 Disease Relevance 0.46 Pain Relevance 0.03
Organophosphorus pesticides cause a loss of parasympathetic prejunctional M2 muscarinic receptor function (Fryer et al. 2004; Lein and Fryer 2005).
Negative_regulation (loss) of M2 muscarinic receptor in parasympathetic
3) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265045 Disease Relevance 0.27 Pain Relevance 0.04
In animals exposed to low concentrations of organophosphorus pesticides, neuronal M2 muscarinic receptor function is lost, increasing release of acetylcholine and potentiating bronchoconstriction (Fryer et al. 2004; Lein and Fryer 2005).
Negative_regulation (lost) of M2 muscarinic receptor in neuronal
4) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265045 Disease Relevance 0.69 Pain Relevance 0
Loss of neuronal M2 muscarinic receptor function in antigen-challenged guinea pigs results from binding of major basic protein, an endogenous M2 muscarinic receptor antagonist released from activated eosinophils (Evans et al. 1997; Jacoby et al. 1993).
Negative_regulation (Loss) of M2 muscarinic receptor in eosinophils associated with antagonist
5) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265045 Disease Relevance 0.25 Pain Relevance 0.05

General Comments

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