INT227044

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp27b1) oxidoreductase activity (Cyp27b1) aging (Cyp27b1)
cytoplasm (Cyp27b1)
Cyp27b1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 15 85.68 High High
agonist 8 65.16 Quite High
Inflammation 9 36.76 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 8 99.14 Very High Very High Very High
Nicotine Addiction 8 82.40 Quite High
Targeted Disruption 22 73.60 Quite High
INFLAMMATION 9 36.76 Quite Low
Hypersensitivity 1 20.48 Low Low
Anaphylactic Hypersensitivity 1 20.08 Low Low
Disease 4 15.04 Low Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Obesity 3 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 5D shows that expression of SEAP and Cyp1a1 in some of the organs decreased after exposure to polluted air, but the result was not consistent with other experiments using distinct pairs of mice (data not shown).
Negative_regulation (decreased) of Gene_expression (expression) of Cyp1a1
1) Confidence 0.06 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.28 Pain Relevance 0.03
Readouts in DO11.10 were taken after 2 to 4 h whereas analysis in the asthma model took place after 48 h; compensatory C1P synthesis (by unknown mechanisms, cf ref. [2]) might be limiting only for short period of times.
Negative_regulation (limiting) of Gene_expression (synthesis) of C1P associated with asthma
2) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.17 Pain Relevance 0.12

General Comments

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