INT22707

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Context Info
Confidence 0.69
First Reported 1984
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 36
Total Number 40
Disease Relevance 27.31
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Eno2) plasma membrane (Eno2) intracellular (Eno2)
cytoplasm (Eno2)
Anatomy Link Frequency
neuron 25
leucocyte 3
plasma 2
brain 2
neuronal 1
Eno2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 4 100.00 Very High Very High Very High
ischemia 126 99.84 Very High Very High Very High
anesthesia 12 99.78 Very High Very High Very High
Lamotrigine 180 98.48 Very High Very High Very High
headache 7 96.80 Very High Very High Very High
cerebral cortex 8 96.64 Very High Very High Very High
abdominal pain 2 93.44 High High
substance P 2 91.52 High High
Pain 11 91.24 High High
Catecholamine 6 89.36 High High
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 18 100.00 Very High Very High Very High
Cancer 116 99.98 Very High Very High Very High
Lymphatic System Cancer 1 99.88 Very High Very High Very High
Cv Unclassified Under Development 122 99.84 Very High Very High Very High
Pheochromocytoma 19 99.78 Very High Very High Very High
Brain Injury 5 99.76 Very High Very High Very High
Paraganglioma 12 99.68 Very High Very High Very High
Empyema Thoracis 2 99.48 Very High Very High Very High
Malignant Neoplastic Disease 11 99.44 Very High Very High Very High
Pleural Effusion 4 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma NSE following permanent or transient MCAO was increased significantly from that observed in controls (2.8 +/- 0.3 ng/ml) beginning at 2 h and persisting for 2.5 days post-MCAO (maximum levels of 8.8 +/- 0.9 to 9.6 +/- 0.5 ng/ml after 6-12 h; P < 0.05, n = 4-9).
Positive_regulation (increased) of NSE in Plasma associated with middle cerebral artery infarction
1) Confidence 0.69 Published 1993 Journal Brain Res. Section Abstract Doc Link 8221097 Disease Relevance 0.93 Pain Relevance 0.10
The plasma norepinephrine concentration was excessive and serum levels of neuron-specific enolase (NSE), calcitonin and parathormone were elevated.
Positive_regulation (elevated) of NSE in neuron
2) Confidence 0.66 Published 1994 Journal Hinyokika Kiyo Section Abstract Doc Link 7801842 Disease Relevance 1.19 Pain Relevance 0.13
The plasma norepinephrine concentration was excessive and serum levels of neuron-specific enolase (NSE), calcitonin and parathormone were elevated.
Positive_regulation (elevated) of neuron-specific enolase in neuron
3) Confidence 0.66 Published 1994 Journal Hinyokika Kiyo Section Abstract Doc Link 7801842 Disease Relevance 1.19 Pain Relevance 0.13
[A case of malignant pheochromocytoma with high levels of serum neuron-specific enolase (NSE) and calcitonin].
Positive_regulation (levels) of NSE in neuron associated with malignant neoplastic disease and pheochromocytoma
4) Confidence 0.66 Published 1994 Journal Hinyokika Kiyo Section Title Doc Link 7801842 Disease Relevance 1.39 Pain Relevance 0.13
The increase level of NSE in serum has been commonly accepted to be as a maker of the neuronal damage.
Positive_regulation (increase) of NSE in neuronal
5) Confidence 0.66 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721363 Disease Relevance 0.56 Pain Relevance 0.24
Similarly, NSE levels were also significantly elevated in hyperglycemic rats.
Positive_regulation (elevated) of NSE
6) Confidence 0.64 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.07 Pain Relevance 0
These data suggest that MCAO-induced cortical infarction and neurological dysfunction is associated with neuronal depletion and vascular redistribution of brain NSE resulting in a measurable increase in plasma NSE.
Positive_regulation (increase) of NSE in brain associated with anesthesia, middle cerebral artery infarction and infarction
7) Confidence 0.60 Published 1993 Journal Brain Res. Section Abstract Doc Link 8221097 Disease Relevance 0.84 Pain Relevance 0.14
[A case of malignant pheochromocytoma with high levels of serum neuron-specific enolase (NSE) and calcitonin].
Positive_regulation (levels) of neuron-specific enolase in neuron associated with malignant neoplastic disease and pheochromocytoma
8) Confidence 0.58 Published 1994 Journal Hinyokika Kiyo Section Title Doc Link 7801842 Disease Relevance 1.39 Pain Relevance 0.13
Our results show an elevated NSE level in serum with decreased NSE staining in the neurons in neonatal rats after HI, confirmed that ischemia may cause the leakage of cytosolic brain enzymes into the blood and the elevation of NSE in serum can reflect the degree of brain damage.
Positive_regulation (elevated) of NSE in neurons associated with ischemia
9) Confidence 0.58 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721363 Disease Relevance 0.56 Pain Relevance 0.24
These granules were argyrophilic by Sevier-Munger staining and intensely immunoreactive for synaptophysin, chromogranin A, neuron-specific enolase, and S-100.
Positive_regulation (immunoreactive) of neuron-specific enolase in neuron
10) Confidence 0.49 Published 2003 Journal Vet. Pathol. Section Abstract Doc Link 12824520 Disease Relevance 0.86 Pain Relevance 0.18
On immunohistochemical examination the neoplastic cells gave positive results for neuron-specific enolase and negative results for chromogranin and epithelial membrane antigen.
Positive_regulation (results) of neuron-specific enolase in neuron
11) Confidence 0.49 Published 1993 Journal J. Comp. Pathol. Section Abstract Doc Link 8315056 Disease Relevance 0.71 Pain Relevance 0.07
Pretreatment with gabapentin prevented the upregulation of GFAP, S100B, and NSE in all brain regions of diabetic rats.
Positive_regulation (upregulation) of NSE in brain
12) Confidence 0.43 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.06 Pain Relevance 0
The NSE level in serum was significantly increased in HI group.
Positive_regulation (increased) of NSE associated with ischemia
13) Confidence 0.42 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721363 Disease Relevance 0.34 Pain Relevance 0.52
20 mg/kg resulted in a significant increase of NSE staining cells in the cortex and a decrease of NSE level in serum (P < 0.01) (Figure 6).
Positive_regulation (increase) of NSE in cortex
14) Confidence 0.39 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721363 Disease Relevance 0.42 Pain Relevance 0.46
Our findings suggest that circulating NSE levels may be clinically useful for early detection of recurrence.
Positive_regulation (circulating) of NSE associated with recurrence
15) Confidence 0.31 Published 2008 Journal Endocr. J. Section Abstract Doc Link 18250540 Disease Relevance 0.79 Pain Relevance 0.06
Our findings suggest that circulating NSE levels may be clinically useful for early detection of recurrence.
Spec (may) Positive_regulation (useful) of NSE associated with recurrence
16) Confidence 0.31 Published 2008 Journal Endocr. J. Section Abstract Doc Link 18250540 Disease Relevance 0.79 Pain Relevance 0.06
Immunohistochemically, the tumour reacted positively for S-100 protein and neuron-specific enolase, indicating its neural origin.
Positive_regulation (reacted) of neuron-specific enolase in neuron associated with cancer
17) Confidence 0.27 Published 2001 Journal J Laryngol Otol Section Abstract Doc Link 11668002 Disease Relevance 0.76 Pain Relevance 0.09
Immuno-histochemically, the tumor cells were positive for cytokeratin, the epithelial membrane antigen, neuron-specific enolase, and chromogranin, but were negative for the leukocyte common antigen and Grimelius stain.
Positive_regulation (positive) of neuron-specific enolase in leukocyte associated with cancer
18) Confidence 0.23 Published 1997 Journal J. Obstet. Gynaecol. Res. Section Abstract Doc Link 9094811 Disease Relevance 1.19 Pain Relevance 0.09
[Pyothorax associated lymphoma with increased neuron-specific enolase level in serum and pleural effusion: a case report].
Positive_regulation (increased) of neuron-specific enolase in neuron associated with pleural effusion, lymphatic system cancer and empyema thoracis
19) Confidence 0.21 Published 2004 Journal Kekkaku Section Title Doc Link 15211877 Disease Relevance 1.16 Pain Relevance 0.09
Immunohistochemically, 2 of 2 tumors were positive for neuron-specific enolase, 9 of 10 tumors for chromogranin, and 2 of 3 tumors for synaptophysin; 3 of 3 tumors were negative for cytokeratin and 1 of 1 tumor negative for HMB-45.
Positive_regulation (positive) of neuron-specific enolase in neuron associated with cancer
20) Confidence 0.21 Published 2004 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 14707870 Disease Relevance 1.35 Pain Relevance 0.05

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