INT227074

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.72
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
mast cells 1
soc (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 42 89.68 High High
depression 138 89.44 High High
TRP channel 2 76.40 Quite High
cva 16 50.32 Quite High
headache 10 29.68 Quite Low
imagery 14 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 16 99.56 Very High Very High Very High
Primary Sclerosing Cholangitis 44 98.28 Very High Very High Very High
Anxiety Disorder 218 91.20 High High
Depression 191 89.44 High High
Brain Hemorrhage 32 89.32 High High
Cv General 4 Under Development 12 88.88 High High
Thrombosis 56 87.52 High High
Vasculitis 2 85.76 High High
Pressure Volume 2 Under Development 4 84.64 Quite High
Coronary Artery Disease 2 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent data imply a stabilization of SOC already at age 15 [15], but contradictory to Antonovsky's statement it has also been reported that SOC increases with age [10,16,17].
Positive_regulation (stabilization) of SOC
1) Confidence 0.54 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2906444 Disease Relevance 0.50 Pain Relevance 0.09
In addition to childhood circumstances, also many other factors called as generalized resistance resources, most importantly education, socio-economic position, social support and work-related factors promote SOC [1,2].
Positive_regulation (promote) of SOC
2) Confidence 0.40 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2831030 Disease Relevance 0.48 Pain Relevance 0.03
Further, the parameters of SOC increased gradually also among somatically and mentally healthy men (OR 1.60, 95% CI 0.87-2.94; OR 1.9, 95% CI 0.99-3.8; OR 2.4, 95% CI 0.96-6.03) suggesting a dose-response relationship between SOC and intention to retire early.
Positive_regulation (increased) of SOC
3) Confidence 0.40 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2831030 Disease Relevance 0.20 Pain Relevance 0
Recent data imply a stabilization of SOC already at age 15 [15], but contradictory to Antonovsky's statement it has also been reported that SOC increases with age [10,16,17].
Positive_regulation (increases) of SOC
4) Confidence 0.32 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2906444 Disease Relevance 0.50 Pain Relevance 0.09
Furthermore, epidemiological data show that changes of SOC are related to societal changes and psychiatric complaints in the population [18]. and interventions with mindfulness based stress reduction lead to an increase of SOC scores [19], which implies that SOC is rather a state measure.
Positive_regulation (increase) of SOC associated with stress
5) Confidence 0.32 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2906444 Disease Relevance 0.44 Pain Relevance 0.07
The findings in our study suggest that a strong SOC can help adolescents choose a coping strategy that is appropriate for the situation and thereby may prevent them from developing PSC, which is in line with other authors findings [21,22].
Positive_regulation (strong) of SOC associated with primary sclerosing cholangitis
6) Confidence 0.31 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2265297 Disease Relevance 0.43 Pain Relevance 0
Stromal interaction molecule 1 (STIM1) is an SR/endoplasmic reticulum (ER)–resident protein necessary for the detection of ER Ca2+ depletion and the activation of SOC channels in T cells (8–10) and mast cells (11).
Positive_regulation (activation) of SOC in mast cells
7) Confidence 0.21 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.58 Pain Relevance 0.10
A major pathway for Ca2+ entry in nonexcitable cells involves receptor-mediated release of intracellular Ca2+ stores, followed by activation of store-operated calcium (SOC) channels in the plasma membrane.
Positive_regulation (activation) of SOC in plasma
8) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442636 Disease Relevance 0.59 Pain Relevance 0.07

General Comments

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