INT22708

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 15
Speculated 8
Reported most in Body
Documents 297
Total Number 305
Disease Relevance 232.71
Pain Relevance 24.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1)
cytoplasm (MUC1)
Anatomy Link Frequency
epithelial cells 15
pancreas 15
goblet cells 8
tear 7
eye 6
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 133 100.00 Very High Very High Very High
Nicotine 27 99.82 Very High Very High Very High
Chronic pancreatitis 471 99.80 Very High Very High Very High
gABA 177 99.70 Very High Very High Very High
Central nervous system 48 99.48 Very High Very High Very High
Bile 399 99.44 Very High Very High Very High
endometriosis 6 99.16 Very High Very High Very High
COX2 4 98.68 Very High Very High Very High
antagonist 23 98.60 Very High Very High Very High
Inflammation 765 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 5215 100.00 Very High Very High Very High
Breast Cancer 1105 100.00 Very High Very High Very High
Nicotine Addiction 1040 100.00 Very High Very High Very High
Adenocarcinoma 779 100.00 Very High Very High Very High
Adhesions 641 100.00 Very High Very High Very High
Eye Disease 445 100.00 Very High Very High Very High
Hypersensitivity 168 100.00 Very High Very High Very High
Lymphatic System Cancer 153 100.00 Very High Very High Very High
Mucinous Cystadenoma 38 100.00 Very High Very High Very High
Nervous System Paraneoplastic Syndromes 16 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemically, MUC1 was expressed at the stromal edge of the micropapillary component and showed the characteristic 'inside-out' pattern of a micropapillary carcinoma.
Gene_expression (expressed) of MUC1 in edge associated with carcinoma
1) Confidence 0.78 Published 2009 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 19561116 Disease Relevance 1.27 Pain Relevance 0.08
We compared the patterns of MUC 1 expression in normal pancreatic tissue, in pancreatic carcinoma, and in chronic pancreatitis.
Gene_expression (expression) of MUC 1 associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.78 Published 1999 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 10549250 Disease Relevance 0.43 Pain Relevance 0.16
Few studies have been performed on the correlation between MUC 1 expression and pancreatic carcinoma using immunohistochemical methods.
Gene_expression (expression) of MUC 1 associated with pancreatic cancer
3) Confidence 0.78 Published 1999 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 10549250 Disease Relevance 0.40 Pain Relevance 0.14
In the neoplastic cells from adenocarcinomas, high levels of cytoplasmic MUC 1 expression were observed, with some membrane staining.
Gene_expression (expression) of MUC 1 associated with adenocarcinoma
4) Confidence 0.78 Published 1999 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 10549250 Disease Relevance 0.45 Pain Relevance 0.18
Differential MUC 1 expression in normal and neoplastic human pancreatic tissue.
Gene_expression (expression) of MUC 1
5) Confidence 0.78 Published 1999 Journal Am. J. Clin. Pathol. Section Title Doc Link 10549250 Disease Relevance 0.39 Pain Relevance 0.15
These data show conspicuous quantitative and qualitative differences between the patterns of MUC 1 expression observed in nonmalignant vs malignant pancreatic tissue and may be useful in the histologic diagnosis of adenocarcinoma in biopsy samples.
Gene_expression (expression) of MUC 1 associated with adenocarcinoma and malignant neoplastic disease
6) Confidence 0.78 Published 1999 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 10549250 Disease Relevance 0.61 Pain Relevance 0.17
In vitro, inflammatory mediators that have been found in the tear film of dry eye patients have been shown to increase MUC1 expression in a human limbal corneal epithelial cell line [23].
Gene_expression (expression) of MUC1 in corneal epithelial cell associated with inflammatory mediators and dry eye
7) Confidence 0.78 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.79 Pain Relevance 0.09
In contrast, other authors have failed to find differences in MUC1 or MUC4 gene expression between controls and SS subjects [32].
Gene_expression (expression) of MUC1 associated with syndrome
8) Confidence 0.78 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.69 Pain Relevance 0
In summary, we quantified the expressions of ocular surface MUC1 in Sjogren’s subjects and compared them with non-Sjogren’s dry-eyed subjects and non-dry eyed controls.
Gene_expression (expressions) of MUC1
9) Confidence 0.78 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.31 Pain Relevance 0.03
We feel that our results are relevant however, as in our study there was no significant age difference between the KCS and SS groups, while there were significant findings in mucin expression.
Gene_expression (expression) of mucin associated with syndrome and sjoegrens syndrome
10) Confidence 0.78 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.38 Pain Relevance 0
We propose that the conjunctival epithelium of Sjogren’s subjects reacts to dry eye changes in the tear film that cause increased shedding of MUC1 and increased production of this molecule in an attempt to protect the ocular surface and to maintain a healthy surface phenotype.



Gene_expression (production) of MUC1 in tear associated with dry eye
11) Confidence 0.78 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.07 Pain Relevance 0
In fact, excess mucin production in humans is an ancient defense mechanism [51] and non-ocular mucous membranes demonstrate excess mucus production under adverse conditions in dogs, rats, and humans [52-54].
Gene_expression (production) of mucin
12) Confidence 0.78 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.69 Pain Relevance 0.04
Perhaps this exposed portion of MUC1 is shed because of physiologic changes associated with severe dry eye disease and this activity then signals the epithelial cells to produce more MUC1.
Gene_expression (produce) of MUC1 in epithelial cells associated with eye disease
13) Confidence 0.78 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.16 Pain Relevance 0.06
This increased mucin activity in the early stages of the keratinisation process, or during inflammation, suggests that ocular surface cells can participate in compensatory attempts to synthesize more mucin to maintain a wet surface phenotype or to protect themselves in other ways.
Gene_expression (synthesize) of mucin associated with inflammation
14) Confidence 0.78 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.77 Pain Relevance 0.09
Also, ocular cicatricial pemphigoid (OCP) patients demonstrate increased mucin production [56].
Gene_expression (production) of mucin associated with conjunctiva disease
15) Confidence 0.78 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.83 Pain Relevance 0.09
Abs from the sera of the C57BL6 mice were predominately of the IgG2a, IgG2b, and IgM isotypes and were reactive against human recombinant MUC1 and MUC1 expressed by the Panc-1 M1F.15 pancreatic cell line.
Gene_expression (expressed) of MUC1
16) Confidence 0.76 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9013982 Disease Relevance 0 Pain Relevance 0.41
Abs from the sera of the C57BL6 mice were predominately of the IgG2a, IgG2b, and IgM isotypes and were reactive against human recombinant MUC1 and MUC1 expressed by the Panc-1 M1F.15 pancreatic cell line.
Gene_expression (expressed) of MUC1
17) Confidence 0.76 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9013982 Disease Relevance 0 Pain Relevance 0.41
MUC1 glycoprotein is present in endometriotic lesions and overexpressed in epithelial ovarian tumors.
Gene_expression (overexpressed) of MUC1 associated with endometriosis and ovarian cancer
18) Confidence 0.76 Published 2006 Journal Immunol. Res. Section Abstract Doc Link 17337783 Disease Relevance 1.43 Pain Relevance 0.35
Our data showed a conspicuous overexpression of CEACAM6 and MUC1 (CA19-9) in pancreatic cancer and cholangiocarcinoma samples, according to the hypothesis that bile fluid collects cancer-associated protein leaking from the tumor microenvironment.
Gene_expression (overexpression) of MUC1 in bile associated with bile, cholangiocarcinoma, cancer and pancreatic cancer
19) Confidence 0.76 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19055478 Disease Relevance 1.85 Pain Relevance 0.43
Experiments where cells were transfected with MUC1 expressing differing VNTR lengths suggest that longer alleles are more efficient at binding H. pylori [45].
Gene_expression (expressing) of MUC1
20) Confidence 0.75 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.43 Pain Relevance 0.06

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