INT2271

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1979
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 51
Total Number 53
Disease Relevance 30.21
Pain Relevance 7.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (F2) peptidase activity (F2) extracellular space (F2)
extracellular region (F2) response to stress (F2)
Anatomy Link Frequency
plasma 6
blood 5
platelet 4
liver 3
PGE1 2
F2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 20 99.84 Very High Very High Very High
Pain 32 99.24 Very High Very High Very High
Restless leg syndrome 4 99.12 Very High Very High Very High
aspirin 65 98.96 Very High Very High Very High
abdominal pain 10 98.18 Very High Very High Very High
fluoxetine 8 98.16 Very High Very High Very High
headache 26 97.66 Very High Very High Very High
Angina 27 96.56 Very High Very High Very High
Dismenorea 10 96.40 Very High Very High Very High
Migraine 15 94.32 High High
Disease Link Frequency Relevance Heat
Coagulation Disorder 57 100.00 Very High Very High Very High
Thrombosis 38 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 1 100.00 Very High Very High Very High
Leptospirosis 56 99.72 Very High Very High Very High
Thrombocytopenia 4 99.70 Very High Very High Very High
Disease 74 99.44 Very High Very High Very High
Poisoning 9 99.36 Very High Very High Very High
Injury 55 99.32 Very High Very High Very High
Pain 35 99.24 Very High Very High Very High
Increased Venous Pressure Under Development 12 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies provide evidence supporting the expression of functionally active prothrombin in the pregnant and nonpregnant rat uterus.
Gene_expression (expression) of prothrombin in uterus
1) Confidence 0.76 Published 2002 Journal J. Soc. Gynecol. Investig. Section Abstract Doc Link 12383911 Disease Relevance 0.10 Pain Relevance 0.10
Based on the presence of its mRNA, prothrombin appears to be synthesized in the endometrium and placenta; in contrast, the myometrial smooth-muscle cells appear to sequester preformed prothrombin.
Gene_expression (synthesized) of prothrombin in muscle cells
2) Confidence 0.76 Published 2002 Journal J. Soc. Gynecol. Investig. Section Abstract Doc Link 12383911 Disease Relevance 0.09 Pain Relevance 0.09
Intrauterine expression of prothrombin in the sprague-dawley rat.
Gene_expression (expression) of prothrombin
3) Confidence 0.76 Published 2002 Journal J. Soc. Gynecol. Investig. Section Title Doc Link 12383911 Disease Relevance 0.19 Pain Relevance 0
These studies sought to determine whether functionally active prothrombin is expressed in the pregnant and nonpregnant rat uterus.
Gene_expression (expressed) of prothrombin in uterus
4) Confidence 0.76 Published 2002 Journal J. Soc. Gynecol. Investig. Section Abstract Doc Link 12383911 Disease Relevance 0.19 Pain Relevance 0
Prothrombin time prolongation in paracetamol poisoning: a relevant marker of hepatic failure?
Gene_expression (prolongation) of Prothrombin associated with liver failure, paracetamol and poisoning
5) Confidence 0.66 Published 2003 Journal Hum Exp Toxicol Section Title Doc Link 14686484 Disease Relevance 0.79 Pain Relevance 0.44
We assessed prothrombin levels and G20210A genotype in a case-control study within the Cardiovascular Health Study.
Gene_expression (levels) of prothrombin
6) Confidence 0.65 Published 2002 Journal Thromb. Haemost. Section Abstract Doc Link 12008943 Disease Relevance 0.77 Pain Relevance 0.09
Formulae F2, F3, and reference containing 0.5 mg of piroxicam in amounts of 100 mg were placed on the cellulose membrane surface facing the donor compartment, and 400 ?
Gene_expression (placed) of F2
7) Confidence 0.38 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2990385 Disease Relevance 0 Pain Relevance 0
Droplet size was also measured for formula F3 by TEM.17 Formula F3 was found to be stable for a three-month period at 40°C, 25°C, and 5°C (data not shown).18 Formulation F1 was excluded from this study because it showed drug precipitation within seven days of preparation.18 Only the F2 and F3 formulae were assessed for their in vitro activity.
Gene_expression (assessed) of F2
8) Confidence 0.38 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2990385 Disease Relevance 0.26 Pain Relevance 0.30
The combined effects of orchiectomy and estrogen administration on synthesis of selected hepatic secretory proteins--antithrombin (AT) III, plasminogen, fibrinogen, factor II (prothrombin), factor VII, fibronectin, and albumin--were studied using the isolated rat liver perfused in vitro for ten hours.
Gene_expression (synthesis) of prothrombin in liver
9) Confidence 0.38 Published 1985 Journal Blood Section Abstract Doc Link 4016277 Disease Relevance 0 Pain Relevance 0.09
Prothrombin factor 1.2 (F1.2) is a cleavage product of prothrombin.
Gene_expression (product) of prothrombin in cleavage
10) Confidence 0.37 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11422096 Disease Relevance 1.00 Pain Relevance 0.47
In the first case a 12 year old boy, who after the removal of the pressure immobilisation bandage, developed decreased fibrinogen levels and positive cross-linked fibrinogen degradation products (XDPs), but normal prothrombin time and activated partial prothrombin time.
Spec (partial) Gene_expression (time) of prothrombin
11) Confidence 0.28 Published 2002 Journal Toxicon Section Abstract Doc Link 11711130 Disease Relevance 0.52 Pain Relevance 0.09
The main differences between the patient who survived and those who died or underwent transplantation were relatively higher activity of alkaline phosphatase (26 U/l vs. 10-20 U/l), slightly higher levels of clotting factors and prothrombin time, which never fall below 68% of the control (versus 14-44% in other patients).
Gene_expression (activity) of prothrombin associated with coagulation disorder
12) Confidence 0.28 Published 2001 Journal Med. Sci. Monit. Section Abstract Doc Link 12211729 Disease Relevance 1.42 Pain Relevance 0.11
Serum bilirubin concentrations, aspartate transaminase, and prolongation of prothrombin time were significantly more abnormal in the fatal cases (p less than 0.01) as compared with the survivors.
Gene_expression (abnormal) of prothrombin
13) Confidence 0.28 Published 1983 Journal Clin Pediatr (Phila) Section Abstract Doc Link 6617055 Disease Relevance 1.21 Pain Relevance 0.16
In the first case a 12 year old boy, who after the removal of the pressure immobilisation bandage, developed decreased fibrinogen levels and positive cross-linked fibrinogen degradation products (XDPs), but normal prothrombin time and activated partial prothrombin time.
Gene_expression (time) of prothrombin
14) Confidence 0.28 Published 2002 Journal Toxicon Section Abstract Doc Link 11711130 Disease Relevance 0.50 Pain Relevance 0.09
Mortality was high (four of seven patients, 57 percent) and characterized by comparatively longer patient histories of colitis, longer current attacks, slightly greater delays between presumed perforation and operation, much higher transfusion requirements, and a 100 percent incidence of coagulopathy (thrombocytopenia and increased prothrombin time in three of four patients, and increased partial thromboplastin time in all four patients).
Gene_expression (time) of prothrombin associated with colitis, coagulation disorder and thrombocytopenia
15) Confidence 0.28 Published 1986 Journal Am. J. Surg. Section Abstract Doc Link 3752375 Disease Relevance 0.74 Pain Relevance 0.08
Plasma levels of the prothrombin activation fragment 1 + 2 (F 1 + 2) and of thrombin antithrombin III complexes (TAT) were determined in 225 patients with angina pectoris undergoing coronary angiography.
Spec (determined) Gene_expression (levels) of prothrombin in Plasma associated with angina
16) Confidence 0.18 Published 1993 Journal Thromb. Haemost. Section Abstract Doc Link 8115978 Disease Relevance 0.30 Pain Relevance 0.17
From induction until 36 hours after surgery, we recorded the postoperative time course of the following markers of coagulation and fibrinolysis: platelet count; fibrinogen level; activated partial thromboplastin time; international normalized ratio; and levels of prothrombin activation fragments 1 and 2, thrombin-antithrombin III complex, and D-dimer.
Gene_expression (levels) of prothrombin in platelet
17) Confidence 0.15 Published 2010 Journal Rev Esp Anestesiol Reanim Section Body Doc Link 20645484 Disease Relevance 0 Pain Relevance 0
Concentrations of fibrinogen, D-dimer, thrombin-antithrombin III complexes, and prothrombin fragment 1,2 are significantly elevated in leptospirosis patients [23].
Gene_expression (Concentrations) of prothrombin associated with leptospirosis
18) Confidence 0.13 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2797087 Disease Relevance 1.86 Pain Relevance 0.07
Although it produces minimal increases in prothrombin and partial thromboplastin times in healthy volunteers, it does not significantly affect the individual clotting factors, nor does it, in patients, enhance the effect of acenocoumarol or phenprocoumon.
Gene_expression (produces) of prothrombin associated with coagulation disorder
19) Confidence 0.11 Published 1979 Journal Rheumatol Rehabil Section Abstract Doc Link 394276 Disease Relevance 0.23 Pain Relevance 0.39
The effects of age, nature (single or multiple) and stated size of overdose, hepatic enzyme induction (gamma-glutamyl transpeptidase, GGT), degree of liver injury (aspartate aminotransferase, prothrombin time), blood pressure and renal injury were assessed.
Gene_expression (time) of prothrombin in blood
20) Confidence 0.09 Published 2009 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 18958458 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox