INT22713

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.19
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.73
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
shoulder 2
plasma 1
FL (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 17 100.00 Very High Very High Very High
Dopamine 2 98.20 Very High Very High Very High
Pain 20 96.32 Very High Very High Very High
monoamine 3 93.96 High High
noradrenaline 1 87.88 High High
spinal dorsal horn 10 87.84 High High
medulla 2 85.52 High High
qutenza 20 83.32 Quite High
Bioavailability 2 83.28 Quite High
Hyperalgesia 4 83.12 Quite High
Disease Link Frequency Relevance Heat
Nociception 26 99.92 Very High Very High Very High
Targeted Disruption 12 98.72 Very High Very High Very High
Hypersensitivity 28 96.52 Very High Very High Very High
Pain 24 96.32 Very High Very High Very High
Hyperalgesia 6 83.12 Quite High
Anxiety Disorder 1 75.84 Quite High
Nervous System Injury 8 73.60 Quite High
INFLAMMATION 24 66.40 Quite High
Stress 4 50.40 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 29.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most studies have focused on trkB.FL as the receptor responsible for BDNF-mediated nociception, since antibodies specific for trkB.FL [12] and abrogation of trkB.FL activation using the trkBF616A transgenic mouse [14] attenuate thermal and mechanical hypersensitivity.
FL Binding (abrogation) of associated with targeted disruption, nociception and hypersensitivity
1) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 1.05 Pain Relevance 0.56
BDNF exerts effects on nociception by binding to trkB.FL and initiating intracellular signaling cascades that lead to transcriptional changes.
FL Binding (binding) of associated with nociception
2) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.56 Pain Relevance 0.36
In addition, we expect computer use to be more strongly associated with hand-arm and neck-shoulder symptoms than ergonomic factors (i.e. working posture and workstation characteristics) [24].
hand-arm Binding (associated) of in shoulder
3) Confidence 0.13 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1550718 Disease Relevance 0 Pain Relevance 0
If ergonomic factors have a causal contribution, one would expect that the association with hand-arm and or neck-shoulder symptoms would become stronger when exposed to longer durations of computer use.
hand-arm Binding (association) of in shoulder
4) Confidence 0.13 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1550718 Disease Relevance 0.05 Pain Relevance 0
The mean blood:plasma concentration ratios of FL and NFL approached unity and plasma protein binding was 85-90% for both compounds.
FL Binding (binding) of in plasma associated with fluoxetine
5) Confidence 0.09 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2320712 Disease Relevance 0 Pain Relevance 0.64
Overall, use of FL complexed with GA significantly modified its behavioral effects, which appears to be associated with the effects of FL and its complexes on the function of the monoaminergic systems involved in controlling behavior.
FL Binding (complexed) of associated with monoamine and fluoxetine
6) Confidence 0.05 Published 2006 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 16583158 Disease Relevance 0.08 Pain Relevance 0.99

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox