INT22715

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Context Info
Confidence 0.64
First Reported 1981
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 22.53
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth) extracellular region (Pth) cellular_component (Pth)
Anatomy Link Frequency
parathyroid 26
parathyroid gland 4
spinal 2
blood 2
spine 2
Pth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 2 100.00 Very High Very High Very High
Opioid 3 99.78 Very High Very High Very High
narcan 12 99.28 Very High Very High Very High
Pain 61 97.08 Very High Very High Very High
cytokine 9 95.32 Very High Very High Very High
headache 6 94.36 High High
Endogenous opioid 1 93.84 High High
colic 1 89.28 High High
Bioavailability 7 87.12 High High
Angina 1 82.08 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 450 100.00 Very High Very High Very High
Hypercalcemia 283 100.00 Very High Very High Very High
Hypocalcemia 13 99.90 Very High Very High Very High
Metastasis 42 99.88 Very High Very High Very High
Hyperplasia 47 99.80 Very High Very High Very High
Reprotox - General 1 35 99.56 Very High Very High Very High
Osgood Schlatter Disease 3 99.52 Very High Very High Very High
Parathyroid Cancer 17 98.96 Very High Very High Very High
Neurologic Manifestations 3 98.48 Very High Very High Very High
Disease 92 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostate cancer bony metastases show increased expression of the PTH receptor (PTH-IR) and PTH promotes the growth and invasiveness of prostate cancer cells in bone.
Positive_regulation (increased) of Gene_expression (expression) of PTH associated with metastasis and reprotox - general 1
1) Confidence 0.64 Published 2008 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18349265 Disease Relevance 1.25 Pain Relevance 0.06
After 2 weeks of suspension, serum iPTH levels increased in all patients, even in those who had the major involutive phenomena.
Positive_regulation (increased) of Gene_expression (levels) of iPTH
2) Confidence 0.57 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2644631 Disease Relevance 0.42 Pain Relevance 0
This concurs, however, with the increases that we found after recovering treatment (after osteopenia) with PTH in the epiphysis.
Positive_regulation (recovering) of Gene_expression (recovering) of PTH in epiphysis associated with osteoporosis
3) Confidence 0.50 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2765647 Disease Relevance 0.10 Pain Relevance 0
CONCLUSION: This case suggests that despite the potential complex pathophysiologic aspects of calciphylaxis, even in the absence of both renal failure and an elevated calcium/phosphorus product, early parathyroidectomy in patients with appreciably increased PTH levels may improve wound healing and diminish pain.


Positive_regulation (increased) of Gene_expression (levels) of PTH
4) Confidence 0.50 Published 2006 Journal Endocr Pract Section Body Doc Link 16901796 Disease Relevance 0 Pain Relevance 0
The PTH followed by Pcb group experienced a significant decrease in lumbar spine BMD (?
Positive_regulation (experienced) of Gene_expression (experienced) of PTH in spine
5) Confidence 0.49 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0 Pain Relevance 0
There were statistically significant differences for lumbar spinal BMD mean percentage change from baseline in favour of PTH 75 ?
Positive_regulation (favour) of Gene_expression (favour) of PTH in spinal
6) Confidence 0.49 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0 Pain Relevance 0
To investigate the occurrence of hypocalcaemia and elevated PTH levels and their relationship to morality and the severity of disease, serum levels of PTH, ionized calcium (Ca2+) and the cytokines interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-alpha) were measured on arrival in the emergency department in a broad spectrum of 140 acutely ill patients patients suffering from common diseases such as stroke, acute abdominal disorders, obstructive lung diseases, heart failure, acute myocardial infarction, angina pectoris, trauma and infectious diseases.
Spec (investigate) Positive_regulation (elevated) of Gene_expression (levels) of PTH in heart associated with hypocalcemia, angina, stroke, disease, cytokine, obstructive airway disease, necrosis, emergencies, cancer, communicable diseases, injury and myocardial infarction
7) Confidence 0.48 Published 1997 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 9466123 Disease Relevance 1.37 Pain Relevance 0.13
Thus decreases in calcitriol levels result in decreased activation of vitamin D receptors, leading to increased expression of PTH and hyperplastic growth of the parathyroid gland.
Positive_regulation (leading) of Gene_expression (expression) of PTH in parathyroid gland associated with hyperplasia
8) Confidence 0.47 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.52 Pain Relevance 0
Prolonged exposure to elevated PTH levels may lead to irreversible parathyroid hyperplasia or significant bone disease by the time patients reach end stage renal disease (ESRD).
Positive_regulation (elevated) of Gene_expression (levels) of PTH in parathyroid associated with chronic renal failure, parathyroid cancer and bone cancer
9) Confidence 0.47 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.95 Pain Relevance 0
Thus decreases in calcitriol levels result in decreased activation of vitamin D receptors, leading to increased expression of PTH and hyperplastic growth of the parathyroid gland.
Positive_regulation (increased) of Gene_expression (expression) of PTH in parathyroid gland associated with hyperplasia
10) Confidence 0.47 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.52 Pain Relevance 0
Prostate cancer bony metastases show increased expression of the PTH receptor (PTH-IR) and PTH promotes the growth and invasiveness of prostate cancer cells in bone.
Positive_regulation (increased) of Gene_expression (expression) of PTH associated with metastasis and reprotox - general 1
11) Confidence 0.46 Published 2008 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18349265 Disease Relevance 1.27 Pain Relevance 0.06
Prostate cancer bony metastases show increased expression of the PTH receptor (PTH-IR) and PTH promotes the growth and invasiveness of prostate cancer cells in bone.
Positive_regulation (increased) of Gene_expression (expression) of PTH associated with metastasis and reprotox - general 1
12) Confidence 0.46 Published 2008 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18349265 Disease Relevance 1.26 Pain Relevance 0.06
After six months with increasing bone pain, pathological fractures and cystic lesions radiologically, hyperparathyroidism was diagnosed by persistent elevated levels of serum calcium, and elevated levels of PTH.
Positive_regulation (elevated) of Gene_expression (levels) of PTH associated with pain, hypercalcemia and spontaneous fractures
13) Confidence 0.46 Published 1990 Journal Tidsskr. Nor. Laegeforen. Section Abstract Doc Link 2321226 Disease Relevance 0.74 Pain Relevance 0.18
These metastases are predominantly blastic (bone-forming) and commonly cause increased serum levels of parathyroid hormone (PTH) as calcium ions are transferred from serum into blastic bone.
Positive_regulation (cause) of Gene_expression (levels) of PTH in parathyroid associated with metastasis
14) Confidence 0.43 Published 2008 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18349265 Disease Relevance 1.03 Pain Relevance 0
These metastases are predominantly blastic (bone-forming) and commonly cause increased serum levels of parathyroid hormone (PTH) as calcium ions are transferred from serum into blastic bone.
Positive_regulation (increased) of Gene_expression (levels) of PTH in parathyroid associated with metastasis
15) Confidence 0.43 Published 2008 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18349265 Disease Relevance 1.03 Pain Relevance 0
CONCLUSION: Routine PTH testing and supplementation for patients with hypoparathyroidism reduced the proportion of patients experiencing hypocalcemia.
Positive_regulation (supplementation) of Gene_expression (testing) of PTH
16) Confidence 0.36 Published 2009 Journal Otolaryngol Head Neck Surg Section Body Doc Link 19932845 Disease Relevance 0 Pain Relevance 0
Primary hyperparathyroidism is a hypercalcemic condition generated as a result of overproduction of parathyroid hormone (PTH) by one or more of the parathyroid glands.
Positive_regulation (overproduction) of Gene_expression (overproduction) of PTH in parathyroid associated with hypercalcemia
17) Confidence 0.35 Published 2004 Journal J. Perianesth. Nurs. Section Abstract Doc Link 15472882 Disease Relevance 0.52 Pain Relevance 0
Primary hyperparathyroidism is a hypercalcemic condition generated as a result of overproduction of parathyroid hormone (PTH) by one or more of the parathyroid glands.
Positive_regulation (overproduction) of Gene_expression (overproduction) of parathyroid hormone in parathyroid associated with hypercalcemia
18) Confidence 0.35 Published 2004 Journal J. Perianesth. Nurs. Section Abstract Doc Link 15472882 Disease Relevance 0.52 Pain Relevance 0
It was also reported that without any significant change in the serum 1,25-dihydroxyvitamin D3 levels as compared with active control (alfacalcidol) in patients with osteoporosis, bisphosphonates such as alendronate decreased serum osteocalcin levels and increased the serum PTH levels from the baseline.1 Thus, comparisons of other serum chemistry markers such as osteocalcin, parathyroid hormone (PTH), 25-hydroxyvitmain D3, and 1,25-dihydroxyvitmain D3 would also be of interest.
Positive_regulation (increased) of Gene_expression (levels) of PTH in parathyroid associated with osteoporosis
19) Confidence 0.21 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2810587 Disease Relevance 0.76 Pain Relevance 0.36
The primary indication for surgery in SHPT patients is an elevated serum PTH level.
Positive_regulation (elevated) of Gene_expression (level) of PTH associated with hypercalcemia
20) Confidence 0.17 Published 2009 Journal World J Surg Section Body Doc Link PMC2712635 Disease Relevance 0.96 Pain Relevance 0

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