INT22719

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.77
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
outflow 2
substantia nigra 2
SOL 2
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 9 99.98 Very High Very High Very High
Nucleus accumbens 6 99.72 Very High Very High Very High
Morphine 7 99.60 Very High Very High Very High
Substantia nigra 1 99.32 Very High Very High Very High
antagonist 1 98.56 Very High Very High Very High
fluoxetine 1 96.96 Very High Very High Very High
medulla 2 96.08 Very High Very High Very High
Serotonin 2 95.84 Very High Very High Very High
Catecholamine 11 95.68 Very High Very High Very High
Neurotransmitter 1 94.44 High High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 8 98.74 Very High Very High Very High
Muscular Atrophy 1 87.92 High High
Paralysis 1 81.44 Quite High
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After microinjection of the neurotoxin 6-hydroxydopamine (6 micrograms/3 microliters, 7 days before) in the substantia nigra, the morphine (10 mg/kg)-induced decrease of ACh was attenuated, and a similar result occurred following reserpine (2 mg/kg, i.p.) 24 h before combined with alpha-methyl-p-tyrosine (300 mg/kg, i.p.) 2.5 h before.
Negative_regulation (attenuated) of Negative_regulation (decrease) of ACh in substantia nigra associated with substantia nigra and morphine
1) Confidence 0.43 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8095326 Disease Relevance 0 Pain Relevance 0.76
This decrease in ACh was blocked by the 5-HT1 (and beta-adrenergic) antagonist propranolol.
Negative_regulation (blocked) of Negative_regulation (decrease) of ACh associated with antagonist
2) Confidence 0.37 Published 1993 Journal Brain Res. Section Abstract Doc Link 8374797 Disease Relevance 0 Pain Relevance 0.49
Denervation for 33 days had no further effect on AChR half-life but reduced the total number of AChRs to about 54% (SOL) or 38% (TA) of normal.
Negative_regulation (reduced) of Negative_regulation (number) of AChRs in SOL
3) Confidence 0.37 Published 1990 Journal Neuron Section Abstract Doc Link 2322461 Disease Relevance 0.17 Pain Relevance 0.08
Thus, naloxone prevented the inhibitory effect of Met-Enk on Ach-stimulated CA release.
Negative_regulation (prevented) of Negative_regulation (effect) of Ach associated with narcan
4) Confidence 0.17 Published 1989 Journal Endocrinology Section Abstract Doc Link 2752969 Disease Relevance 0 Pain Relevance 0.74
Addition of beta-amyloid fragment(25 - 35) (0.01 - 1 microM) in the superfusion medium suppressed the K(+)-evoked [(3)H]-ACh release from the rat hippocampal slices in a concentration-related manner and about 40 % reduction in ACh outflow was observed when incubating with the highest concentration of an amyloid fragment (1 microM).
Negative_regulation (suppressed) of Negative_regulation (reduction) of ACh in outflow associated with alzheimer's dementia
5) Confidence 0.11 Published 2001 Journal Planta Med. Section Abstract Doc Link 11582541 Disease Relevance 0.60 Pain Relevance 0.12

General Comments

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