INT227201

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 0.29
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
embryos 3
juvenile 2
bands 2
neurons 1
brain structure 1
SCO (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 12 100.00 Very High Very High Very High
ketamine 140 93.36 High High
anesthesia 56 92.64 High High
Spinal cord 168 88.88 High High
GABAergic 12 84.92 Quite High
GABA receptor 4 75.96 Quite High
Neurotransmitter 40 73.68 Quite High
Serotonin 28 48.28 Quite Low
Dopamine 28 47.40 Quite Low
imagery 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 12 100.00 Very High Very High Very High
Adhesions 28 51.44 Quite High
Volume Depletion And Dehydration 28 45.00 Quite Low
Sprains And Strains 28 5.00 Very Low Very Low Very Low
Congenital Anomalies 28 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 28 5.00 Very Low Very Low Very Low
Vibrio Infection 8 5.00 Very Low Very Low Very Low
Hypothermia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological studies suggested that SCO suppression was mediated by P2Y2/P2Y4 receptors.
Gene_expression (suppression) of SCO
1) Confidence 0.09 Published 2008 Journal The Journal of General Physiology Section Abstract Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.04
It has also been shown that both, the floor plate and SCO of bovine embryos, express the SCO-spondin gene and synthesize the 540 kDa protein [39].
Gene_expression (express) of SCO in embryos
2) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Two other compounds (200, 63 kDa) were present in SCO, RF and CSF and may be processed forms.
Gene_expression (present) of SCO
3) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Efforts to detect SCO glycoproteins in the bovine CSF have failed [18,19].
Gene_expression (detect) of SCO
4) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
With the exception of the 200-kDa compound, all high molecular mass compounds present in the rat SCO were also present in the mouse SCO (Fig. 2C).


Gene_expression (present) of SCO
5) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.04
When UTP was added in presence of membrane-impermeable NO scavenger c-PTIO, the [Ca2+]i signal in astrocytes was comparable to that observed in the absence of scavenger but the neuronal SCO persisted (Fig. 6 E), indicating the involvement of diffusible NO in SCO suppression. c-PTIO significantly enhanced the SCO amplitude in control (nucleotide untreated) cultures (Fig. 6 D).
Gene_expression (suppression) of SCO in astrocytes
6) Confidence 0.08 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0.06 Pain Relevance 0.03
The possible role of NO in ATP/UTP-induced SCO suppression was tested.
Gene_expression (suppression) of SCO
7) Confidence 0.08 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0.08 Pain Relevance 0.10
Analysis of [Ca2+]i changes in networked neurons and the astrocytes in the same field revealed that ATP/UTP induced a robust but transient [Ca2+]i signal in astrocytes that coincided with depression of neuronal SCO (Fig. 5, D and E).


Gene_expression (depression) of SCO in neurons associated with depression
8) Confidence 0.08 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0.10 Pain Relevance 0.20
Comparative analysis of immunoreactive secretory proteins in the rat SCO, RF and CSF
Gene_expression (analysis) of SCO
9) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Comparative analysis of immunoreactive secretory proteins in the rat SCO, RF and CSF
Gene_expression (rat) of SCO
10) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
(ii) Two other compounds (200, 63 kDa) were present in SCO, RF and CSF (Tables 2, 3), possibly processed forms; (iii) three compounds (200, 120, 63 kDa) were present in RF and CSF (Table 2) and possibly in a steady-state equilibrium; (iv) CSF of rat embryos had five bands (180, 164, 145, 50, 25 kDa) not detected in the rat SCO or RF at PN30 (Table 2, compare Figs. 2D and 2E); (v) CSF of PN30 rats had two bands (50, 25 kDa) not detected in the rat SCO and inconsistently detected in RF at PN30 (Table 2).
Neg (not) Gene_expression (detected) of SCO in bands
11) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
SCO extracts
Gene_expression (extracts) of SCO
12) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.27
Ontogenetic studies have revealed that the SCO starts to express a secretory activity much earlier than the appearance of the first RF [1,15].
Gene_expression (express) of SCO
13) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Protein content of rat SCO extracts ranged from 1.5 to 2.2 ?
Gene_expression (extracts) of SCO
14) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.14
l samples of SCO extracts, containing the equivalent of 0.02 bovine SCO, 1 mouse SCO and 1 rat SCO; (ii) 50 ?
Gene_expression (extracts) of SCO
15) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.03
In the fetal CSF the number and concentration of SCO secretory products is higher than in the CSF of juvenile rats
Gene_expression (products) of SCO in juvenile
16) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
(ii) Two other compounds (200, 63 kDa) were present in SCO, RF and CSF (Tables 2, 3), possibly processed forms; (iii) three compounds (200, 120, 63 kDa) were present in RF and CSF (Table 2) and possibly in a steady-state equilibrium; (iv) CSF of rat embryos had five bands (180, 164, 145, 50, 25 kDa) not detected in the rat SCO or RF at PN30 (Table 2, compare Figs. 2D and 2E); (v) CSF of PN30 rats had two bands (50, 25 kDa) not detected in the rat SCO and inconsistently detected in RF at PN30 (Table 2).
Neg (not) Gene_expression (detected) of SCO in bands
17) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Two structures, the floor plate and the SCO, have been shown to share the property to synthesize RF-like material [36,37].
Gene_expression (synthesize) of SCO in floor plate
18) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Evidence for the existence of two precursor forms of the secretory proteins in the rat and mouse SCO
Gene_expression (rat) of SCO
19) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Thus, whether the SCO proteins forming RF and the SCO proteins solubilized in the CSF are the same, or similar or unrelated compounds has yet to be determined.
Gene_expression (proteins) of SCO
20) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0.05 Pain Relevance 0

General Comments

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