INT227202

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 0.56
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
central canal 3
gland 3
cerebrospinal fluid 2
third ventricle 2
juvenile 2
SCO (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 90.16 High High
Spinal cord 246 90.08 High High
depression 6 80.92 Quite High
Neurotransmitter 20 78.16 Quite High
Glutamate 10 76.12 Quite High
ketamine 205 68.00 Quite High
Dopamine 41 59.04 Quite High
Serotonin 41 57.36 Quite High
cerebral cortex 41 38.80 Quite Low
anesthesia 82 22.24 Low Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 41 88.08 High High
Congenital Anomalies 41 82.96 Quite High
Depression 6 80.92 Quite High
Adhesions 41 65.60 Quite High
Sprains And Strains 41 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 41 5.00 Very Low Very Low Very Low
Vibrio Infection 4 5.00 Very Low Very Low Very Low
Hypothermia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional significance of the existence of CSF-soluble proteins secreted by the SCO
Localization (secreted) of SCO
1) Confidence 0.10 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Identification of the precursor and processed forms of the glycoproteins secreted by the rat and mouse SCO
Localization (secreted) of SCO
2) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
In order to identify those compounds secreted by the SCO into the CSF and that, at variance with RF-glycoproteins, remain soluble in the CSF, samples of this fluid were obtained from embryo, early postnatal and juvenile rats and analysed by immunoblotting using AFRU and anti-P15.
Localization (secreted) of SCO in juvenile
3) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.04
The rat SCO starts to secrete AFRU-reactive material at E14; by E18 it is fully developed and displaying a high secretory activity [1].
Localization (secrete) of SCO
4) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Are CSF-soluble compounds secreted by the SCO intracellularly processed and released into CSF, or "released" from RF?
Localization (released) of SCO
5) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
The existence of CSF-soluble compounds secreted by the SCO gained support by immunochemical studies in human and rabbit CSF [2,16].
Localization (secreted) of SCO
6) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
The possibility that these proteins result from a post-release cleavage of compounds secreted by the SCO into the CSF has to be considered and investigated.
Localization (secreted) of SCO in cleavage
7) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.04
On the other hand, the four AFRU-immunoreactive proteins present only in the CSF collected from E18 to PN1 could be secreted by the SCO, the floor plate or by both glands.
Localization (secreted) of SCO in glands
8) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
These findings suggest that the embryonic SCO secretes compounds that remain soluble in the CSF, thus differing from RF proteins, which aggregate.
Localization (secretes) of SCO
9) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
In the absence of exogenously added ATP/UTP, both the NO scavenger and NOS inhibitor enhanced the frequency of SCO, implying that NO is released even during spontaneous synaptic transmission and exerts a suppressive effect on synaptic activity.
Neg (NO) Localization (released) of SCO
10) Confidence 0.09 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0.08 Pain Relevance 0.12
In the absence of exogenously added ATP/UTP, both the NO scavenger and NOS inhibitor enhanced the frequency of SCO, implying that astrocytes release NO during spontaneous synaptic activity and exert a suppressive effect.
Neg (NO) Localization (release) of SCO in astrocytes
11) Confidence 0.09 Published 2008 Journal The Journal of General Physiology Section Abstract Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.04
l samples of SCO extracts, containing the equivalent of 0.02 bovine SCO, 1 mouse SCO and 1 rat SCO; (ii) 50 ?
Localization (equivalent) of SCO
12) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.03
l samples of SCO extracts, containing the equivalent of 0.02 bovine SCO, 1 mouse SCO and 1 rat SCO; (ii) 50 ?
Localization (equivalent) of SCO
13) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.03
According to the lectin binding properties of all AFRU-immunoreactive glycoproteins present in the rat and mouse SCO (Table 1), the 630 and 390 kDa compounds would correspond to precursor forms present in the rough endoplasmic reticulum of the SCO secretory cells.
Localization (secretory cells) of SCO in secretory cells
14) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
The two proteins of 180 and 164 kDa, found in the embryonic CSF but absent from the juvenile SCO, CSF and RF, would correspond to processed forms released by the SCO during late embryonic life.
Localization (released) of SCO in juvenile
15) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.04
Thus, whether the SCO proteins forming RF and the SCO proteins solubilized in the CSF are the same, or similar or unrelated compounds has yet to be determined.
Localization (solubilized) of SCO
16) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0.05 Pain Relevance 0
Reissner's fiber results from the assembly of large molecular weight proteins released by the SCO into the CSF circulating through the cerebral aqueduct.
Localization (released) of SCO in cerebral aqueduct
17) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
It may be assumed that the source of these proteins is the SCO since in the juvenile rat this gland is the only brain structure secreting AFRU-reactive proteins.
Localization (secreting) of SCO in brain structure
18) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Since RF starts to form at PN1, and a RF proper is first seen in the central canal at PN7, it has been assumed that the compounds secreted by the fetal SCO remain soluble in the CSF [1].
Localization (secreted) of SCO in central canal
19) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
Are CSF-soluble compounds secreted by the SCO intracellularly processed and released into CSF, or "released" from RF?
Localization (secreted) of SCO
20) Confidence 0.09 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0

General Comments

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