INT227209

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 16
Disease Relevance 0.24
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
astrocytes 5
neurons 2
SCO (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 105 99.32 Very High Very High Very High
Potency 15 99.12 Very High Very High Very High
Action potential 30 98.80 Very High Very High Very High
Neurotransmitter 150 96.40 Very High Very High Very High
GABAergic 45 95.04 Very High Very High Very High
Glutamate 75 92.40 High High
nMDA receptor antagonist 15 92.00 High High
tetrodotoxin 15 90.84 High High
sodium channel 15 90.00 High High
GABA receptor 15 86.08 High High
Disease Link Frequency Relevance Heat
Depression 45 82.88 Quite High
Vibrio Infection 30 5.00 Very Low Very Low Very Low
Hypothermia 15 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results established the involvement of NO in nucleotide-induced suppression of SCO.
Negative_regulation (suppression) of SCO
1) Confidence 0.07 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0
Taken together these data imply that activation of P2Y2/P2Y4 receptors on astrocytes causes inhibition of SCO.
Negative_regulation (inhibition) of SCO in astrocytes
2) Confidence 0.07 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.03
We therefore infer that NO produced in astrocytes diffuses into the neurons and thus attenuates SCO.
Negative_regulation (attenuates) of SCO in neurons
3) Confidence 0.07 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.03
We think that the SCO suppression is mediated by P2Y2 and P2Y4 receptors because UTP mimicked ATP in suppressing the SCO with almost the same potency, and the suppression was sensitive to suramin but not PPADS, which are the characteristics of these receptors (Fields and Burnstock, 2006).
Negative_regulation (suppression) of SCO associated with potency
4) Confidence 0.06 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.26
Addition of AMPA/kainate receptor antagonist CNQX to the perfusate completely abolished the SCO and this effect was reverted after washout of CNQX (Fig. 1 C).
Negative_regulation (abolished) of SCO associated with antagonist
5) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.26
We observed that a pulse of extracellular ATP/UTP suppressed the SCO in a reversible manner and a robust Ca2+ signal in astrocytes was concomitant with SCO inhibition.
Negative_regulation (suppressed) of SCO in astrocytes
6) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.06
The SCO were blocked by nimodipine and CNQX completely abolished the SCO, suggesting that the SCO arise due to Ca2+ entry through voltage-gated Ca2+ channels for which AMPA receptor activation is mandatory.
Negative_regulation (blocked) of SCO
7) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.31
The nitric oxide donor DETA/NO effectively suppressed the SCO.
Negative_regulation (suppressed) of SCO
8) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Abstract Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.04
The possible role of NO in ATP/UTP-induced SCO suppression was tested.
Negative_regulation (suppression) of SCO
9) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0.08 Pain Relevance 0.10
We hypothesized that a messenger molecule other than ATP released from astrocytes acts on neurons to suppress the SCO.
Negative_regulation (suppress) of SCO in neurons
10) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.03
Our data demonstrate that NO released from activated astrocytes acts presynaptically to suppress the SCO.
Negative_regulation (suppress) of SCO in astrocytes
11) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0.08 Pain Relevance 0.09
In the absence of functional UTP receptors (P2Y2 and P2Y4) in postsynaptic neurons and presynaptic terminals, the suppression of SCO by UTP/ATP most likely occurs via astrocytes.
Negative_regulation (suppression) of SCO in astrocytes
12) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0.08 Pain Relevance 0.21
We think that the SCO suppression is mediated by P2Y2 and P2Y4 receptors because UTP mimicked ATP in suppressing the SCO with almost the same potency, and the suppression was sensitive to suramin but not PPADS, which are the characteristics of these receptors (Fields and Burnstock, 2006).
Negative_regulation (suppressing) of SCO associated with potency
13) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.25
SCO suppression was considerably diminished by removal of extracellular NO by membrane-impermeable scavenger c-PTIO or by pretreatment of cells with nitric oxide synthase inhibitor L-NAME.
Negative_regulation (suppression) of SCO
14) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Abstract Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.05
We observed that a pulse of extracellular ATP/UTP suppressed the SCO in a reversible manner and a robust Ca2+ signal in astrocytes was concomitant with SCO inhibition.
Negative_regulation (inhibition) of SCO in astrocytes
15) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.03
Blots of bovine, rat and mouse SCO in parallel to those used for immunoblotting, were used to test for lectin binding.
Negative_regulation (Blots) of SCO
16) Confidence 0.05 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0

General Comments

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