INT227260

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2011
Negated 5
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 5.42
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp1) mitochondrion (Ucp1) transmembrane transport (Ucp1)
Anatomy Link Frequency
liver 2
Ucp1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 36 98.04 Very High Very High Very High
Glutamate 6 74.00 Quite High
agonist 12 60.12 Quite High
cerebral cortex 3 55.08 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 345 99.84 Very High Very High Very High
Impaired Glucose Tolerance 24 98.04 Very High Very High Very High
Insulin Resistance 18 96.16 Very High Very High Very High
Hypoxia 68 93.84 High High
Body Weight 69 88.04 High High
Fatty Liver 6 85.76 High High
Cancer 188 74.52 Quite High
Diabetes Mellitus 18 54.60 Quite High
Weight Gain 3 50.00 Quite Low
Cardiovascular Disease 3 40.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, there was no significant difference in UCP1 mRNA expression of BAT among the four groups in this study.
Neg (no) Regulation (difference) of Gene_expression (expression) of UCP1 mRNA associated with obesity
1) Confidence 0.60 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.21 Pain Relevance 0.07
Effects of GhrR KO on UCP1 and UCP2 mRNA expression in response to HFD
Regulation (Effects) of Gene_expression (expression) of UCP1
2) Confidence 0.51 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.47 Pain Relevance 0.11
There were no significant differences in UCP-1 mRNA expression of BAT among the four groups (Fig. 3A).
Neg (no) Regulation (differences) of Gene_expression (expression) of UCP-1 mRNA associated with obesity
3) Confidence 0.44 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.27 Pain Relevance 0.04
Further studies are needed to evaluate the effect of BOF on thermogenesis and UCP1 expression in human WAT.



Regulation (effect) of Gene_expression (expression) of UCP1 associated with obesity
4) Confidence 0.44 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 0.98 Pain Relevance 0.12
Effects of GhrR KO on UCP1 and UCP2 mRNA expression in response to HFD
Regulation (Effects) of Gene_expression (expression) of UCP1
5) Confidence 0.37 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.47 Pain Relevance 0.11
However, UCP1 expression had little effect on baseline oxygen consumption (figure 3B and 3C).
Neg (little) Regulation (effect) of Gene_expression (expression) of UCP1
6) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737639 Disease Relevance 0.38 Pain Relevance 0
In contrast to liver-UCP2, there was no change in BAT-UCP1 mRNA expression in HFD-fed GhrR KO mice (Figure 6B).


Neg (no) Regulation (change) of Gene_expression (expression) of UCP1 mRNA in liver
7) Confidence 0.22 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.27 Pain Relevance 0
Addition of oligomycin had little effect on UCP1 overexpressing cells, while it decreased oxygen consumption in control cells (figure 3B).
Neg (little) Regulation (effect) of Gene_expression (overexpressing) of UCP1
8) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737639 Disease Relevance 0.36 Pain Relevance 0

General Comments

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