INT227265

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.50
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp2) mitochondrion (Ucp2)
Anatomy Link Frequency
liver 4
nervous system 2
Ucp2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 93.80 High High
Inflammatory response 2 92.80 High High
metalloproteinase 1 79.08 Quite High
tolerance 32 64.40 Quite High
Inflammation 11 47.56 Quite Low
cerebral cortex 5 31.16 Quite Low
Somatostatin 17 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 164 99.84 Very High Very High Very High
Lifespan 33 99.38 Very High Very High Very High
Atherosclerosis 7 96.20 Very High Very High Very High
Aging 15 96.08 Very High Very High Very High
INFLAMMATION 14 92.44 High High
Fatty Liver 5 85.68 High High
Hyperglycemia 9 83.72 Quite High
Dyslipidemia /

Combined Dyslipidemia

2 83.00 Quite High
Death 6 81.20 Quite High
Hyperlipidemia 5 68.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is plausible to hypothesize that functional UCP2 gene polymorphisms leading to reduced expression of UCP2 may be related to a proinflammatory status and possibly to the development and progression of atherosclerosis.
Negative_regulation (reduced) of Gene_expression (expression) of UCP2 associated with atherosclerosis
1) Confidence 0.57 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.55 Pain Relevance 0.16
Likewise, in the present study hepatic expression of UCP2 mRNA was lower in HFD-fed GhrR KO mice.
Negative_regulation (lower) of Gene_expression (expression) of UCP2 mRNA
2) Confidence 0.50 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.13 Pain Relevance 0
Ghrelin deficiency has been associated previously with a decrease in mitochondrial UCP2 mRNA expression in the livers of chow-fed mice [3].
Negative_regulation (decrease) of Gene_expression (expression) of UCP2 mRNA in livers
3) Confidence 0.50 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.14 Pain Relevance 0
In the present study GhrR KO mice fed a HFD showed significantly reduced UCP2 expression relative to HFD-fed WT mice (Figure 6A), consistent with the decreased hepatic steatosis in HFD-fed GhrR KO mice [2].
Negative_regulation (reduced) of Gene_expression (expression) of UCP2
4) Confidence 0.37 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.38 Pain Relevance 0.06
Taken together, our results suggest that lower expression of UCP2 mRNA of liver reflects improved lipid metabolism in HFD-fed GhrR KO mice and likely contributes to the overall insulin sensitivity in these animals.
Negative_regulation (lower) of Gene_expression (expression) of UCP2 mRNA in liver
5) Confidence 0.37 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.12 Pain Relevance 0
mRNA expression of UCP1 and UCP2 in WAT and BAT
Negative_regulation (mRNA) of Gene_expression (expression) of UCP2 associated with obesity
6) Confidence 0.35 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.32 Pain Relevance 0.03
Similar patterns of survival have been described in other aging models: in Caenorhabditis elegans, ablation of ASI sensory neurons that modulate DAF-2 pathways in response to environment, increased mean, but not maximum lifespan [27]; in Drosophila, targeted expression of human uncoupling protein 2 in adult neurons [42], or inhibition of p53 specifically in the nervous system [43], extended mean, but not maximum, lifespan.
Negative_regulation (inhibition) of Gene_expression (expression) of uncoupling protein 2 in nervous system associated with aging and lifespan
7) Confidence 0.04 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.79 Pain Relevance 0

General Comments

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