INT227268

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.93
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
fat 6
plasma 2
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 27 93.44 High High
Inflammation 14 82.96 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 205 100.00 Very High Very High Very High
Diabetes Mellitus 32 99.60 Very High Very High Very High
Targeted Disruption 10 99.04 Very High Very High Very High
Impaired Glucose Tolerance 27 94.08 High High
Congenital Anomalies 3 92.92 High High
Metabolic Syndrome 81 91.40 High High
Hyperlipidemia 3 84.88 Quite High
Insulin Resistance 61 83.88 Quite High
INFLAMMATION 10 82.96 Quite High
Cardiovascular Disease 4 76.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, the mRNA levels of adiponectin in the WAT were markedly decreased 8 weeks after the treatment with a high-fat diet, and this decrease preceded the decrease in the plasma adiponectin protein levels.
Negative_regulation (decreased) of Transcription (levels) of adiponectin in fat associated with obesity
1) Confidence 0.52 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.37 Pain Relevance 0.06
Mesenteric fat was increased nearly four times in this animal and expression of mRNA of adiponectin was decreased to 42% compared to non-transgenic mice.
Negative_regulation (decreased) of Transcription (expression) of adiponectin in fat associated with targeted disruption
2) Confidence 0.39 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.10 Pain Relevance 0.13
The mRNA expression of adiponectin and its plasma levels are significantly reduced in obese/diabetic mice [13] and humans [14].
Negative_regulation (reduced) of Transcription (expression) of adiponectin in plasma associated with diabetes mellitus and obesity
3) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.37 Pain Relevance 0.07
Our previous study using this model demonstrated that mRNA expression of adiponectin in WAT was markedly decreased beginning at 8 weeks in the high-fat diet-fed mice [8].
Negative_regulation (decreased) of Transcription (expression) of adiponectin in fat associated with obesity
4) Confidence 0.33 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.09 Pain Relevance 0.03

General Comments

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