INT227269

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.54
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp1) mitochondrion (Ucp1) transmembrane transport (Ucp1)
Anatomy Link Frequency
liver 2
Ucp1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 27 63.68 Quite High
Eae 21 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 191 99.96 Very High Very High Very High
Obesity 486 99.48 Very High Very High Very High
Targeted Disruption 124 91.64 High High
Hypoxia 68 84.80 Quite High
Pancreatic Cancer 10 78.12 Quite High
Impaired Glucose Tolerance 16 64.32 Quite High
Body Weight 108 61.52 Quite High
Weight Gain 4 50.00 Quite Low
Hyperlipidemia 3 41.80 Quite Low
Hyperinsulinism 12 39.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BAT is a thermogenic organ in which increased expression of UCP1 decreases mitochondrial energy efficiency, leading to the generation of heat [17].
Negative_regulation (decreases) of Gene_expression (expression) of UCP1
1) Confidence 0.48 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0 Pain Relevance 0
mRNA expression of UCP1 and UCP2 in WAT and BAT
Negative_regulation (mRNA) of Gene_expression (expression) of UCP1 associated with obesity
2) Confidence 0.41 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.32 Pain Relevance 0.03
As shown in Fig. 3, the gene and protein expression levels of Ucp-1 and Ucp-3 were down-regulated in ob/ob mice and up-regulated in iNOS-deficient mice as compared to those of wild type mice.
Negative_regulation (down) of Gene_expression (levels) of Ucp-1 associated with obesity
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.57 Pain Relevance 0
Immunohistological analyses showed a high expression of Ucp-1 and Ucp-3 in BAT in all experimental groups.
Negative_regulation (showed) of Gene_expression (expression) of Ucp-1 associated with obesity
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.44 Pain Relevance 0
Sections were incubated overnight at 4°C with rabbit monoclonal anti-Ucp-1 or Ucp-3 antibodies (Abcam) diluted 1?
Negative_regulation (diluted) of Gene_expression (antibodies) of Ucp-1
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.08 Pain Relevance 0
Additionally, the levels of UCP2 and UCP1 were reduced in the liver and BAT, respectively, in GhrR KO mice relative to WT mice.


Negative_regulation (reduced) of Gene_expression (levels) of UCP1 in liver
6) Confidence 0.36 Published 2011 Journal BMC Physiol Section Abstract Doc Link PMC3024223 Disease Relevance 0.24 Pain Relevance 0.03
Conversely, expression of the mitochondrial uncoupling protein 1 (UCP1) increased oxygen consumption and decreased tumor growth.
Negative_regulation (decreased) of Gene_expression (expression) of UCP1 associated with cancer
7) Confidence 0.32 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2737639 Disease Relevance 0.95 Pain Relevance 0
Conversely, expression of the mitochondrial uncoupling protein 1 (UCP1) increased oxygen consumption and decreased tumor growth.
Negative_regulation (decreased) of Gene_expression (expression) of uncoupling protein 1 associated with cancer
8) Confidence 0.28 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2737639 Disease Relevance 0.95 Pain Relevance 0

General Comments

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