INT227270

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 7.35
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 6
adipocyte 2
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 22 99.52 Very High Very High Very High
Cannabinoid receptor 62 99.20 Very High Very High Very High
agonist 82 97.84 Very High Very High Very High
Endocannabinoid 29 87.84 High High
Inflammation 22 81.88 Quite High
Cannabinoid 7 67.08 Quite High
antagonist 12 65.04 Quite High
cannabis 13 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 458 99.84 Very High Very High Very High
Impaired Glucose Tolerance 26 99.84 Very High Very High Very High
Metabolic Syndrome 57 99.56 Very High Very High Very High
Targeted Disruption 9 97.40 Very High Very High Very High
Diabetes Mellitus 43 96.48 Very High Very High Very High
Hyperinsulinism 3 96.28 Very High Very High Very High
Cardiovascular Disease 6 94.00 High High
Body Weight 38 91.40 High High
Toxicity 3 87.32 High High
Increased Venous Pressure Under Development 5 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because adiponectin is reported to be decreased in obesity, we investigated the changes in adiponectin expression in epididymal WAT and the plasma adiponectin levels in high-fat diet-fed mice (Fig. 4A and B).
Spec (investigated) Regulation (changes) of Gene_expression (expression) of adiponectin in plasma associated with obesity and metabolic syndrome
1) Confidence 0.55 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.80 Pain Relevance 0.08
In the present study, we first measured the changes in serum adiponectin concentration and adiponectin mRNA expression in WAT, because adiponectin mRNA expression and adiponectin plasma levels was reported to be significantly reduced in obese/diabetic mice [21] and humans [22].
Regulation (changes) of Gene_expression (expression) of adiponectin mRNA in plasma associated with diabetes mellitus and obesity
2) Confidence 0.48 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.30 Pain Relevance 0
In the future, it will be necessary to investigate the effects of BOF treatment on adiponectin expression or glucose tolerance in a study with a longer follow-up.
Spec (investigate) Regulation (effects) of Gene_expression (expression) of adiponectin associated with tolerance and impaired glucose tolerance
3) Confidence 0.35 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.18 Pain Relevance 0.05
However, no significant differences were observed among the groups in serum adiponectin concentration or adiponectin mRNA expression in WAT.
Regulation (groups) of Gene_expression (expression) of adiponectin mRNA associated with obesity
4) Confidence 0.35 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.23 Pain Relevance 0.03
fat depots and regulates the expression of adipocyte-secreted hormones that
Regulation (regulates) of Gene_expression (expression) of adipocyte in adipocyte
5) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.61 Pain Relevance 0.13
Moreover, adiponectin expression is up-regulated by the blockade of CB1 receptors only in CB1+/+, but not CB1-/- knockout, mice [32].


Regulation (regulated) of Gene_expression (expression) of adiponectin associated with targeted disruption and cannabinoid receptor
6) Confidence 0.11 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2832623 Disease Relevance 0.91 Pain Relevance 0.56
This SNP has been also associated to altered plasma levels of LPL, leptin, adiponectin, and resistin.
Regulation (altered) of Gene_expression (levels) of adiponectin in plasma
7) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 1.33 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox