INT227272

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 8.29
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
fat 4
plasma 2
adipose tissue 1
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 56 92.32 High High
withdrawal 3 85.04 High High
Inflammation 21 82.96 Quite High
agonist 60 81.44 Quite High
anesthesia 10 16.20 Low Low
Glutamate 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 13 99.92 Very High Very High Very High
Obesity 751 99.84 Very High Very High Very High
Necrosis 3 99.68 Very High Very High Very High
Targeted Disruption 22 98.48 Very High Very High Very High
Diabetes Mellitus 86 97.68 Very High Very High Very High
Impaired Glucose Tolerance 54 92.96 High High
Congenital Anomalies 6 92.92 High High
Metabolic Syndrome 127 91.40 High High
Hyperlipidemia 6 84.88 Quite High
Insulin Resistance 101 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, the mRNA levels of adiponectin in the WAT were markedly decreased 8 weeks after the treatment with a high-fat diet, and this decrease preceded the decrease in the plasma adiponectin protein levels.
Transcription (levels) of adiponectin in fat associated with obesity
1) Confidence 0.64 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.36 Pain Relevance 0.06
The mRNA expression of adiponectin and of GAPDH as an internal control in the adipose tissue was determined by real-time polymerase chain reaction (PCR).
Spec (determined) Transcription (expression) of adiponectin in adipose tissue associated with obesity
2) Confidence 0.55 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 0.46 Pain Relevance 0
Our previous study using this model demonstrated that mRNA expression of adiponectin in WAT was markedly decreased beginning at 8 weeks in the high-fat diet-fed mice [8].
Transcription (expression) of adiponectin in fat associated with obesity
3) Confidence 0.53 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.09 Pain Relevance 0.03
Mesenteric fat was increased nearly four times in this animal and expression of mRNA of adiponectin was decreased to 42% compared to non-transgenic mice.
Transcription (expression) of adiponectin in fat associated with targeted disruption
4) Confidence 0.48 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.09 Pain Relevance 0.13
The mRNA expression of adiponectin and its plasma levels are significantly reduced in obese/diabetic mice [13] and humans [14].
Transcription (expression) of adiponectin in plasma associated with diabetes mellitus and obesity
5) Confidence 0.47 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.36 Pain Relevance 0.07
The same group studied mRNA expression of leptin and adiponectin in epididymal fat of 11?
Transcription (expression) of adiponectin in fat
6) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.52 Pain Relevance 0
Effects of BOF and DAI on mRNA expression of adiponectin and its plasma levels
Transcription (expression) of adiponectin in plasma
7) Confidence 0.41 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.26 Pain Relevance 0
Unlike positive control human WAT cDNA analyzed in parallel, Tusc5 mRNA was nondetectable in HepG2 cells under all conditions (transcripts for leptin and AdipoQ/adiponectin were also not detected).
Transcription (transcripts) of AdipoQ associated with obesity
8) Confidence 0.30 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.32 Pain Relevance 0.07
Unlike positive control human WAT cDNA analyzed in parallel, Tusc5 mRNA was nondetectable in HepG2 cells under all conditions (transcripts for leptin and AdipoQ/adiponectin were also not detected).
Transcription (transcripts) of adiponectin associated with obesity
9) Confidence 0.30 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.37 Pain Relevance 0.07
The mRNA expression levels of adiponectin, tumor necrosis factor-?
Transcription (expression) of adiponectin associated with necrosis and cancer
10) Confidence 0.21 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.45 Pain Relevance 0.04

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