INT227273

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Context Info
Confidence 0.72
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 18.04
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
adipose tissue 5
adipocyte 3
endocrine organ 2
plasma 1
liver 1
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 13 99.88 Very High Very High Very High
antagonist 23 97.84 Very High Very High Very High
agonist 225 96.72 Very High Very High Very High
Cannabinoid receptor 62 95.04 Very High Very High Very High
Inflammation 117 94.96 High High
Cannabinoid 7 92.60 High High
cytokine 38 91.08 High High
Kinase C 9 84.32 Quite High
tolerance 138 83.68 Quite High
Endocannabinoid 29 76.32 Quite High
Disease Link Frequency Relevance Heat
Obesity 1001 99.84 Very High Very High Very High
Metabolic Syndrome 185 99.84 Very High Very High Very High
Frailty 11 99.68 Very High Very High Very High
Hyperglycemia 25 99.62 Very High Very High Very High
Impaired Glucose Tolerance 131 99.26 Very High Very High Very High
Insulin Resistance 184 98.84 Very High Very High Very High
Atherosclerosis 59 98.56 Very High Very High Very High
Diabetes Mellitus 282 98.36 Very High Very High Very High
Shock 184 98.24 Very High Very High Very High
Cardiovascular Disease 39 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the 11th day from the start of differentiation (before the peak of adiponectin secretion), dexamethasone was removed from the medium. 24 hours later, the cells were subjected to treatments as follows: medium only, 100 nM cortisone, 0.1 ?
Localization (secretion) of adiponectin associated with dexamethasone
1) Confidence 0.72 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.29 Pain Relevance 0.05
Recently it was shown that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and confers some of adiponectin's actions [11], and thus may be an important mediator of adiponectin-dependent insulin sensitization in skeletal muscle.
Localization (sensitization) of adiponectin-dependent in skeletal muscle
2) Confidence 0.68 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.72 Pain Relevance 0
Adiponectin is not only decreased in obese individuals but also in type 2 diabetic patients [7] and a low level is a risk factor for developing this disease [13].
Localization (decreased) of Adiponectin associated with diabetes mellitus, obesity and disease
3) Confidence 0.68 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.74 Pain Relevance 0
Similar findings were reported by Yamauchi et al. [15–17], who demonstrated that adiponectin is decreased in obesity and deficient in mice that are lacking in specific adipose tissues that play a causal role in the development of insulin resistance, and that the replenishment of adiponectin might provide a novel treatment modality for insulin resistance, type 2 diabetes, and atherosclerosis.
Localization (decreased) of adiponectin in adipose tissues associated with diabetes mellitus, metabolic syndrome, increased venous pressure under development and insulin resistance
4) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.61 Pain Relevance 0.03
Adiponectin concentrations released into the culture medium increased by 1.5-fold, from 13.6 ng/ml in the absence of compound to 20.1 ng/ml in its presence (mean values from pooled samples of sextuplicate determinations).
Localization (released) of Adiponectin
5) Confidence 0.63 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.51 Pain Relevance 0.06
This is in accordance with other studies where glucocorticoid is reported to inhibit both expression and secretion of adiponectin [6,28].
Localization (secretion) of adiponectin
6) Confidence 0.63 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.99 Pain Relevance 0.12
Accumulating evidence suggests that adipose tissue is not simply an inert energy storage depot but also functions as a major endocrine organ, producing and releasing a variety of bioactive substances, especially adiponectin, into the bloodstream [4].
Localization (releasing) of adiponectin in endocrine organ associated with obesity
7) Confidence 0.63 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.42 Pain Relevance 0
fat depots and regulates the expression of adipocyte-secreted hormones that
Localization (secreted) of adipocyte in adipocyte
8) Confidence 0.56 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.60 Pain Relevance 0.13
Accumulating evidence suggests that adipose tissue is not simply an inert energy storage depot but also functions as a major endocrine organ, producing and releasing a variety of bioactive substances, especially adiponectin, into the bloodstream [7].
Localization (releasing) of adiponectin in endocrine organ associated with obesity
9) Confidence 0.54 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.58 Pain Relevance 0
Since the isolation of the first-known adipocyte-secreted
Localization (secreted) of adipocyte in adipocyte
10) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.86 Pain Relevance 0.05
guarantees a balanced and adequate production of adipocytokine secretion such as adiponectin from adipose tissue, factors which are important mediators of insulin action in peripheral tissues [38]–[40].
Localization (secretion) of adiponectin in adipose tissue associated with obesity
11) Confidence 0.45 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.81 Pain Relevance 0.11
and adiponectin, which are adipocytokines secreted by adipose tissues (Fig. 3E,F), as mentioned above.
Localization (secreted) of adiponectin in adipose tissues
12) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.32 Pain Relevance 0
Serum insulin, adiponectin and TNF-?
Localization (Serum) of adiponectin
13) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.08 Pain Relevance 0.11
target gene adiponectin (AdipoQ, probably from Kuppfer cells), and following overexpression of either PPAR?
Localization (target) of adiponectin
14) Confidence 0.32 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.27 Pain Relevance 0.03
isoform the relative abundance of adiponectin was massively increased in relative terms (Figure 4), as expected based on prior reports using these liver samples [12, 13].
Localization (abundance) of adiponectin in liver
15) Confidence 0.32 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.27 Pain Relevance 0.03
target gene adiponectin (AdipoQ, probably from Kuppfer cells), and following overexpression of either PPAR?
Localization (target) of AdipoQ
16) Confidence 0.32 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.27 Pain Relevance 0.03
Adiponectin is secreted exclusively by adipose tissue, with plasma levels negatively correlated with obesity [33].
Localization (secreted) of Adiponectin in plasma associated with obesity and metabolic syndrome
17) Confidence 0.29 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2832623 Disease Relevance 0.77 Pain Relevance 0.60
Our laboratory has demonstrated that astragaloside II and isoastragaloside I from Radix Astragali alleviate insulin resistance, glucose intolerance and hyperglycemia by increasing the secretion of the insulin sensitizing hormone, adiponectin from adipocytes [17].
Localization (secretion) of adiponectin in adipocytes associated with hyperglycemia, obesity, insulin resistance and impaired glucose tolerance
18) Confidence 0.28 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.93 Pain Relevance 0.03
Adiponectin is secreted by adipose tissue (i.e., an adipokine) and is a key modulator of insulin sensitivity [43, 75, 78]).
Localization (secreted) of Adiponectin in adipose tissue associated with obesity
19) Confidence 0.26 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 1.23 Pain Relevance 0.06
Indeed, adipose tissue is able to secrete a number of “adipokines” [17] some of them, like resistin, leptin, adiponectin, Monocyte Chemoattractant Protein-1, Interleukin-6, angiotensinogen, angiotensin-converting enzyme, plasminogen activator inhibitor-1 (PAI-1), being implicated in cardiovascular disease [rev. in 18, 19].
Localization (secrete) of adiponectin in adipose tissue associated with cardiovascular disease and obesity
20) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2936567 Disease Relevance 1.07 Pain Relevance 0

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