INT227274

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 9.79
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp2) mitochondrion (Ucp2)
Anatomy Link Frequency
adipose tissue 2
fat 1
skeletal muscle 1
Ucp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 23 98.32 Very High Very High Very High
tolerance 40 97.04 Very High Very High Very High
agonist 46 87.92 High High
Inflammatory response 8 82.04 Quite High
cytokine 3 43.92 Quite Low
Glutamate 10 34.92 Quite Low
metalloproteinase 1 29.20 Quite Low
anesthesia 6 21.76 Low Low
Bile 16 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 523 99.84 Very High Very High Very High
INFLAMMATION 30 98.32 Very High Very High Very High
Impaired Glucose Tolerance 44 97.04 Very High Very High Very High
Stress 30 95.96 Very High Very High Very High
Hepatotoxicity 4 92.88 High High
Diabetes Mellitus 75 90.32 High High
Body Weight 41 89.28 High High
Overweight 6 87.16 High High
Cardiovascular Disease 14 80.00 Quite High
Disease 11 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One, conducted in healthy children and adolescents, showed that the G variant of UCP2 was associated with markers of low grade inflammation (i.e. fibrinogen, complement C3 and complement C4) [26].
Transcription (variant) of UCP2 associated with inflammation
1) Confidence 0.67 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.81 Pain Relevance 0.09
There were no significant differences in UCP2 mRNA expression in BAT or WAT among the four groups (Fig. 4).


Transcription (expression) of UCP2 associated with obesity
2) Confidence 0.59 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.01 Pain Relevance 0.05
Thus the second aim of the present study was to investigate the effect of BOF and DAI on the mRNA expression of UCP1 and UCP2 in the BAT and WAT in high-fat diet-fed mice.


Transcription (expression) of UCP2 in fat associated with obesity
3) Confidence 0.59 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.41 Pain Relevance 0.07
Stimulated mRNA expression of uncoupling protein 2 (Ucp2) by PPAR?
Transcription (expression) of Ucp2
4) Confidence 0.58 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.96 Pain Relevance 0.10
Stimulated mRNA expression of uncoupling protein 2 (Ucp2) by PPAR?
Transcription (expression) of uncoupling protein 2
5) Confidence 0.58 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.96 Pain Relevance 0.10
mRNA expression of UCP1 and UCP2 in WAT and BAT
Transcription (expression) of UCP2 associated with obesity
6) Confidence 0.44 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.32 Pain Relevance 0.03
In addition, the mRNA expression levels of uncoupling protein 1 (UCP1) and UCP2 mRNA in WAT and brown adipose tissue (BAT) were measured. 6-week-old KK/Ta mice were divided into four groups and fed a purified powdered basal diet (the BD group), a purified high-fat (HF) powdered diet containing suet powder at 37.5 g/100 g diet (the HF group), a high-fat diet plus 1.0% bofutsushosan (BOF) treatment (the HF + BOF group), or a high-fat diet plus 1.0% daisaikoto (DAI) treatment (the HF + DAI group) for 4 weeks.
Transcription (expression) of UCP2 in adipose tissue associated with obesity
7) Confidence 0.44 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2266052 Disease Relevance 1.38 Pain Relevance 0.05
In addition, the mRNA expression levels of uncoupling protein 1 (UCP1) and UCP2 mRNA in WAT and brown adipose tissue (BAT) were measured. 6-week-old KK/Ta mice were divided into four groups and fed a purified powdered basal diet (the BD group), a purified high-fat (HF) powdered diet containing suet powder at 37.5 g/100 g diet (the HF group), a high-fat diet plus 1.0% bofutsushosan (BOF) treatment (the HF + BOF group), or a high-fat diet plus 1.0% daisaikoto (DAI) treatment (the HF + DAI group) for 4 weeks.
Transcription (levels) of UCP2 in adipose tissue associated with obesity
8) Confidence 0.44 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2266052 Disease Relevance 1.38 Pain Relevance 0.05
In skeletal muscle, the expression of UCP2 mRNA was significantly increased by berberine [10].
Transcription (expression) of UCP2 in skeletal muscle
9) Confidence 0.43 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.57 Pain Relevance 0
RT–PCR analysis comparing Srebp-1c, Ppard, Ppara, Ins (proinsulin), Ucp-2, Ampk and Gck mRNA expression in BRIN-BD11 cells treated in the absence or presence of increasing concentrations of AA for 24 h was performed.
Transcription (expression) of Ucp-2
10) Confidence 0.26 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0
However, there was no significant change in proinsulin, Ucp-2 or Gck mRNA expression following 24-h stimulation with AA.
Transcription (expression) of Ucp-2
11) Confidence 0.26 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0

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