INT227275

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 19.51
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 18
fat 8
visceral 2
adipose tissue 2
adipocytes 2
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 39 95.72 Very High Very High Very High
Inflammation 113 93.36 High High
tolerance 128 82.48 Quite High
qutenza 5 82.44 Quite High
fibrosis 2 67.56 Quite High
Inflammatory response 14 64.48 Quite High
Chronic pancreatitis 1 48.88 Quite Low
ischemia 1 46.88 Quite Low
Eae 2 25.24 Quite Low
cytokine 12 13.36 Low Low
Disease Link Frequency Relevance Heat
Obesity 921 100.00 Very High Very High Very High
Insulin Resistance 277 99.92 Very High Very High Very High
Metabolic Syndrome 324 99.88 Very High Very High Very High
Diabetes Mellitus 187 99.60 Very High Very High Very High
Fatty Liver 92 99.00 Very High Very High Very High
Targeted Disruption 41 97.88 Very High Very High Very High
Impaired Glucose Tolerance 126 96.32 Very High Very High Very High
Disorder Of Lipid Metabolism 28 94.96 High High
INFLAMMATION 118 93.36 High High
Congenital Anomalies 11 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HSD1 in adipose tissue with decreased adiponectin expression in mesenteric fat [4].
Negative_regulation (decreased) of Gene_expression (expression) of adiponectin in fat associated with obesity
1) Confidence 0.53 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.01 Pain Relevance 0.12
The treatment with a high-fat diet markedly decreased the adiponectin mRNA expression in mice at 14 weeks of age compared to the mice before treatment, and this decrease continued in mice 22 weeks of age.
Negative_regulation (decreased) of Gene_expression (expression) of adiponectin mRNA in fat
2) Confidence 0.52 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.69 Pain Relevance 0.07
The major finding of this study included the following: (1) the increase in visceral adipose tissue preceded development of fatty liver and insulin resistance; (2) the increase in size of white adipocytes was an early event as the fist step to obesity; (3) adiponectin mRNA expression was markedly decreased before the decrease in its plasma levels or the development of insulin resistance; and (4) insulin resistance appeared in association with fatty infiltration and TNF-?
Negative_regulation (decreased) of Gene_expression (expression) of adiponectin mRNA in plasma associated with fatty liver, obesity, metabolic syndrome and insulin resistance
3) Confidence 0.52 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.92 Pain Relevance 0
The mRNA expression of adiponectin and its plasma levels are significantly reduced in obese/diabetic mice [13] and humans [14].
Negative_regulation (reduced) of Gene_expression (expression) of adiponectin in plasma associated with diabetes mellitus and obesity
4) Confidence 0.52 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.37 Pain Relevance 0.07
In the present study, we first measured the changes in serum adiponectin concentration and adiponectin mRNA expression in WAT, because adiponectin mRNA expression and adiponectin plasma levels was reported to be significantly reduced in obese/diabetic mice [21] and humans [22].
Negative_regulation (reduced) of Gene_expression (expression) of adiponectin in plasma associated with diabetes mellitus and obesity
5) Confidence 0.45 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.28 Pain Relevance 0
The mRNA expression of adiponectin is reduced in adipose tissue in obese mice and humans [12] although the picture differs somewhat depending on fat depot.
Negative_regulation (reduced) of Gene_expression (expression) of adiponectin in fat associated with obesity
6) Confidence 0.38 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.65 Pain Relevance 0
HSD1 inhibitor BVT2733 on adiponectin concentrations
Negative_regulation (inhibitor) of Gene_expression (concentrations) of adiponectin
7) Confidence 0.38 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.20 Pain Relevance 0
Although there were no significant differences in several parameters between the basal diet group and the high-fat diet group at the end of experiment (22-week-old mice), several characteristics of the metabolic syndrome, including visceral adipose tissue accumulation and decreased adiponectin expression were developed more earlier in the high-fat diet group compared to the basal diet group.
Negative_regulation (decreased) of Gene_expression (expression) of adiponectin in visceral associated with obesity and metabolic syndrome
8) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.31 Pain Relevance 0.04
Adiponectin mRNA expression in WAT was markedly decreased before the decrease in its plasma levels or the development of insulin resistance.
Negative_regulation (decreased) of Gene_expression (expression) of Adiponectin mRNA in plasma associated with obesity and insulin resistance
9) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2266061 Disease Relevance 1.59 Pain Relevance 0
In addition, the decrease in plasma adiponectin levels was correlated with the increases in plasma insulin and HOMA-IR.
Negative_regulation (decrease) of Gene_expression (levels) of adiponectin in plasma
10) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.34 Pain Relevance 0.03
mRNA expression of adiponectin and its plasma level
Negative_regulation (level) of Gene_expression (expression) of adiponectin in plasma
11) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.93 Pain Relevance 0.08
This is in accordance with other studies where glucocorticoid is reported to inhibit both expression and secretion of adiponectin [6,28].
Negative_regulation (inhibit) of Gene_expression (expression) of adiponectin
12) Confidence 0.34 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.01 Pain Relevance 0.12
Our previous study using this model demonstrated that mRNA expression of adiponectin in WAT was markedly decreased beginning at 8 weeks in the high-fat diet-fed mice [8].
Negative_regulation (decreased) of Gene_expression (expression) of adiponectin in fat associated with obesity
13) Confidence 0.33 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.09 Pain Relevance 0.03
In the present study, we first measured the changes in serum adiponectin concentration and adiponectin mRNA expression in WAT, because adiponectin mRNA expression and adiponectin plasma levels was reported to be significantly reduced in obese/diabetic mice [21] and humans [22].
Negative_regulation (reduced) of Gene_expression (expression) of adiponectin mRNA in plasma associated with diabetes mellitus and obesity
14) Confidence 0.33 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.29 Pain Relevance 0
Effects of BOF and DAI on mRNA expression of adiponectin and its plasma levels
Negative_regulation (mRNA) of Gene_expression (expression) of adiponectin in plasma
15) Confidence 0.33 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.26 Pain Relevance 0
Plasma adiponectin levels decrease during obesity, and are negatively associated with plasma insulin, positively associated with plasma triglycerides, and correlate with increases in HOMA-IR [6].
Negative_regulation (decrease) of Gene_expression (levels) of adiponectin in plasma associated with metabolic syndrome
16) Confidence 0.24 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 1.08 Pain Relevance 0.07
target genes Lpl, PEPCK, CD36, and adiponectin was markedly decreased in adipose tissue from PPAR?
Negative_regulation (decreased) of Gene_expression (genes) of adiponectin in adipose tissue associated with obesity
17) Confidence 0.24 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.34 Pain Relevance 0.03
, the association of T/T genotype with decreased serum adiponectin level was observed only in the subgroup with higher values (risk groups), not in subgroups with lower values.
Negative_regulation (decreased) of Gene_expression (level) of serum adiponectin
18) Confidence 0.23 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2849047 Disease Relevance 1.20 Pain Relevance 0
-induced downregulation of adiponectin expression in adipocytes [34].
Negative_regulation (downregulation) of Gene_expression (expression) of adiponectin in adipocytes associated with obesity
19) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2876247 Disease Relevance 0.89 Pain Relevance 0.49

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