INT227331

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.83
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xdh) oxidoreductase activity (Xdh) extracellular region (Xdh)
peroxisome (Xdh) cytoplasm (Xdh)
Anatomy Link Frequency
intestine 2
muscle 1
Xdh (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 8 79.44 Quite High
antagonist 2 63.76 Quite High
Inflammation 33 60.80 Quite High
ischemia 41 57.08 Quite High
cytokine 17 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 15 99.62 Very High Very High Very High
Diabetes Mellitus 2 99.08 Very High Very High Very High
Disease 11 99.04 Very High Very High Very High
Myocardial Infarction 16 85.96 High High
Gastroenteritis 1 74.24 Quite High
Stress 46 69.64 Quite High
Injury 207 62.64 Quite High
Shock 20 62.04 Quite High
INFLAMMATION 45 60.80 Quite High
Apoptosis 27 59.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased XOR activity in the absence of NO attenuation is associated with the pathophysiology of cardiac dysfunction [34],[39],[40] and inhibition of XOR using allopurinal has previously been shown beneficial for maintaining normal cardiac and vascular hemodynamics [39].
XOR Binding (associated) of
1) Confidence 0.29 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 0.24 Pain Relevance 0
A recent study in patients with type II diabetes suggests that urate lowering per se does not improve endothelial function.15

Xanthine oxidase (XO)

Xanthine oxidase Neg (not) Binding (improve) of associated with diabetes mellitus
2) Confidence 0.16 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.33 Pain Relevance 0.06
Treatment with allopurinol or its active metabolite oxypurinol, which blocks XO activity by binding at its active site (55), has been associated with a decrease in the levels of indicators of oxidative damage and markers of muscle damage after exhaustive exercise protocols in humans and rats (14, 16).
XO Binding (binding) of in muscle
3) Confidence 0.16 Published 2010 Journal American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Section Body Doc Link PMC2806206 Disease Relevance 0.06 Pain Relevance 0
On reperfusion, as molecular oxygen is reintroduced in the hypoxic intestine, oxygen reacts with hypoxanthine and xanthine oxidase to generate superoxide anion (·O2?)
xanthine oxidase Binding (reacts) of in intestine associated with hypoxia
4) Confidence 0.02 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.60 Pain Relevance 0.21
On reperfusion, as molecular oxygen is reintroduced in the hypoxic intestine, oxygen reacts with hypoxanthine and xanthine oxidase to generate superoxide anion (·O2?)
xanthine oxidase Binding (hypoxanthine) of in intestine associated with hypoxia
5) Confidence 0.02 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.60 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox