INT22738

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Context Info
Confidence 0.57
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 6.68
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DYNLL1) transport (DYNLL1) mitochondrion (DYNLL1)
plasma membrane (DYNLL1) cytoskeleton (DYNLL1) nucleus (DYNLL1)
Anatomy Link Frequency
dermatome 2
cilia 1
joint 1
liver 1
leg 1
DYNLL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 2 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
epidural 9 99.32 Very High Very High Very High
Pain 24 97.36 Very High Very High Very High
local anesthetic 1 90.08 High High
visual analogue scale 4 89.72 High High
Paresthesia 3 88.64 High High
lidocaine 7 84.24 Quite High
Quantitative sensory testing 2 75.12 Quite High
anesthesia 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 108 99.84 Very High Very High Very High
Infection 9 99.48 Very High Very High Very High
Foreign Bodies 7 98.36 Very High Very High Very High
Discitis 3 97.76 Very High Very High Very High
Neck Pain 3 97.36 Very High Very High Very High
Neuropathy 24 96.52 Very High Very High Very High
Brain Abscess 1 96.24 Very High Very High Very High
Dysesthesia 4 94.60 High High
Cancer 2 94.52 High High
Pain 18 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared with other scales, the UENS emphasizes severity and spatial distribution of pin (sharp) sensation loss in the foot and leg and focuses less on motor weakness.
Negative_regulation (loss) of pin in leg
1) Confidence 0.57 Published 2008 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 18844788 Disease Relevance 1.02 Pain Relevance 0.08
The level of pin prick sensation was reduced in accordance with the duration of LT application.
Negative_regulation (reduced) of pin
2) Confidence 0.57 Published 1997 Journal Masui Section Abstract Doc Link 9369053 Disease Relevance 0.29 Pain Relevance 0.69
The other four complications included drainage from a pin site, which resolved after removal of the pin: a three by two-centimeter skin slough, which spontaneously epithelialized; aseptic resorption of the distal end of the humerus and proximal end of the ulna, which stopped after immobilization and subsequent bracing of the elbow but resulted in moderate instability; and ulnar-nerve paresthesia, which was not operatively treated and persisted.
Negative_regulation (removal) of pin in ulna associated with paresthesia
3) Confidence 0.42 Published 1990 Journal J Bone Joint Surg Am Section Abstract Doc Link 2324148 Disease Relevance 0.63 Pain Relevance 0.10
The patients were evaluated with regard to erythema, drainage, cellulitis, occurrence of pain at each pin-site, clinical or radiographic evidence of pin-loosening, the need for antibiotics, and the need for pin removal before fracture-healing due to infection.
Negative_regulation (removal) of pin
4) Confidence 0.42 Published 2008 Journal J Trauma Section Body Doc Link 18469650 Disease Relevance 0 Pain Relevance 0
Uncomplicated removal of this pin was followed in 36 days by the development of cervical spondylodiscitis that failed conservative management and required surgical debridement and arthrodesis.
Negative_regulation (removal) of pin associated with discitis
5) Confidence 0.42 Published 2005 Journal J. Pediatr. Surg. Section Abstract Doc Link 15793746 Disease Relevance 0.54 Pain Relevance 0.18
Following validation in animal models, oral L-arginine, intracavernosal antagonists of NMDA receptor and PIN, and intracavernosal or systemic PnNOS, may eventually translate to clinical trials.
Negative_regulation (antagonists) of PIN associated with nmda receptor and antagonist
6) Confidence 0.42 Published 2000 Journal Drugs Today Section Abstract Doc Link 12879114 Disease Relevance 0.15 Pain Relevance 0.16
Laparoscopic removal of an ingested pin migrating into the liver.
Negative_regulation (removal) of pin in liver
7) Confidence 0.42 Published 2002 Journal Surg Endosc Section Title Doc Link 11928045 Disease Relevance 0.24 Pain Relevance 0
A 59-year-old man had loss of pin-prick and temperature sensation over his head, face, neck, trunk, and all extremities while light touch, vibration, joint position sense, and deep pain were preserved.
Negative_regulation (loss) of pin in joint associated with pain
8) Confidence 0.42 Published 1985 Journal Arch. Neurol. Section Abstract Doc Link 4026636 Disease Relevance 0.30 Pain Relevance 0.20
A blinded observer recorded loss of pin-prick sensation every minute in the C2-C4 dermatomes until readiness for surgery.
Negative_regulation (loss) of pin in dermatomes
9) Confidence 0.42 Published 2000 Journal Can J Anaesth Section Body Doc Link 10674516 Disease Relevance 0 Pain Relevance 0
The change in sensation, loss of pin-prick and pain threshold sensation, measured by pressure algometer, were assessed at 2.5-min intervals for 15 min at the T4 dermatome.
Negative_regulation (loss) of pin in dermatome
10) Confidence 0.42 Published 1996 Journal Can J Anaesth Section Body Doc Link 8955968 Disease Relevance 0.17 Pain Relevance 0
The epidural block was evaluated by assessing loss of pin-prick sensation.
Negative_regulation (loss) of pin associated with epidural
11) Confidence 0.42 Published 1989 Journal Pain Section Abstract Doc Link 2710559 Disease Relevance 0.17 Pain Relevance 0.34
The average operative time for pin removal was 42 min (range, 12-132).
Negative_regulation (removal) of pin
12) Confidence 0.42 Published 1996 Journal J Pediatr Orthop Section Abstract Doc Link 8747355 Disease Relevance 0.09 Pain Relevance 0
Alfentanil effectively inhibited electrically evoked pain and reduced pin prick hyperalgesia and allodynia during its infusion.
Negative_regulation (reduced) of pin
13) Confidence 0.41 Published 2001 Journal Anesthesiology Section Body Doc Link 11506112 Disease Relevance 0.14 Pain Relevance 0
Quantification of prosthetic outcomes: elastomeric gel liner with locking pin suspension versus polyethylene foam liner with neoprene sleeve suspension.
Negative_regulation (locking) of pin
14) Confidence 0.41 Published 2004 Journal J Rehabil Res Dev Section Title Doc Link 15558387 Disease Relevance 0.14 Pain Relevance 0.14
Eight of the 12 patients (66.7%) with pin site problems (8 pin loosening; 4 pin site infections) experienced failure with HVI.
Negative_regulation (loosening) of pin associated with infection
15) Confidence 0.30 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908866 Disease Relevance 0.67 Pain Relevance 0.10
Compared with other scales, the UENS emphasizes severity and spatial distribution of pin (sharp) sensation loss in the foot and leg and focuses less on motor weakness.
Negative_regulation (loss) of pin in foot
16) Confidence 0.19 Published 2008 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 18844788 Disease Relevance 1.02 Pain Relevance 0.08
Finally a cytoplasmic dynein, dynein cytoplasmic 2 heavy chain 1 (DYNC2H1), which is the retrograde motor of the cilia, was significantly downregulated in smokers (p<0.001).


Negative_regulation (downregulated) of cytoplasmic dynein in cilia associated with nicotine addiction
17) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790614 Disease Relevance 1.11 Pain Relevance 0

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