INT2274

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Context Info
Confidence 0.62
First Reported 1976
Last Reported 2011
Negated 17
Speculated 11
Reported most in Abstract
Documents 101
Total Number 112
Disease Relevance 41.55
Pain Relevance 34.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
blood 10
pancreatic islets 6
plasma 6
vagus nerves 4
neural 4
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 214 100.00 Very High Very High Very High
adenocard 162 100.00 Very High Very High Very High
tolerance 126 100.00 Very High Very High Very High
narcan 101 100.00 Very High Very High Very High
Somatostatin 60 100.00 Very High Very High Very High
Cholecystokinin 59 100.00 Very High Very High Very High
Action potential 40 100.00 Very High Very High Very High
Enkephalin 39 100.00 Very High Very High Very High
opiate 32 100.00 Very High Very High Very High
qutenza 29 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1196 100.00 Very High Very High Very High
Obesity 288 100.00 Very High Very High Very High
Insulin Resistance 261 100.00 Very High Very High Very High
Disease 142 100.00 Very High Very High Very High
Impaired Glucose Tolerance 133 100.00 Very High Very High Very High
Stress 74 100.00 Very High Very High Very High
Hyperinsulinism 66 100.00 Very High Very High Very High
Headache 18 100.00 Very High Very High Very High
Sleep Disorders 7 100.00 Very High Very High Very High
Cognitive Disorder 3 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate possible synergistic interactions between these inhibitory agents upon the regulation of insulin release in man, we examined the effects of PGE, epinephrine and the long-acting met-enkephalin analogue FK 33-824, given alone or in combination, upon glucose-induced insulin secretion in normal man.
Regulation (regulation) of Localization (release) of insulin associated with enkephalin
1) Confidence 0.62 Published 1985 Journal Diabete Metab Section Abstract Doc Link 3908178 Disease Relevance 0 Pain Relevance 0.17
Clonidine, naloxone and CB-154 plus naloxone lowered insulin plasma levels; CB-154 alone caused only a slight reduction, whereas clonidine plus naloxone did not affect insulin secretion.
Neg (not) Regulation (affect) of Localization (secretion) of insulin in plasma associated with narcan and clonidine
2) Confidence 0.62 Published 1981 Journal J. Endocrinol. Invest. Section Abstract Doc Link 7037921 Disease Relevance 0 Pain Relevance 0.90
Neuroendocrine control of basal insulin secretion in man: a study with bromocriptine, clonidine and naloxone.
Regulation (control) of Localization (secretion) of insulin associated with narcan and clonidine
3) Confidence 0.62 Published 1981 Journal J. Endocrinol. Invest. Section Title Doc Link 7037921 Disease Relevance 0 Pain Relevance 0.93
These results prove the existence of a complex neuroendocrine control of basal insulin secretion through dopaminergic, adrenergic and opiate mechanisms; they also suggest that the opiate inhibitory control of insulin release may be dissociated from the dopaminergic one, but may interact with the adrenergic one.
Regulation (control) of Localization (secretion) of insulin associated with opiate
4) Confidence 0.62 Published 1981 Journal J. Endocrinol. Invest. Section Abstract Doc Link 7037921 Disease Relevance 0 Pain Relevance 0.89
Interaction between epinephrine, prostaglandin E, and met-enkephalin in the regulation of insulin release in man.
Regulation (regulation) of Localization (release) of insulin associated with enkephalin
5) Confidence 0.62 Published 1985 Journal Diabete Metab Section Title Doc Link 3908178 Disease Relevance 0.06 Pain Relevance 0.18
These results prove the existence of a complex neuroendocrine control of basal insulin secretion through dopaminergic, adrenergic and opiate mechanisms; they also suggest that the opiate inhibitory control of insulin release may be dissociated from the dopaminergic one, but may interact with the adrenergic one.
Regulation (control) of Localization (release) of insulin associated with opiate
6) Confidence 0.62 Published 1981 Journal J. Endocrinol. Invest. Section Abstract Doc Link 7037921 Disease Relevance 0 Pain Relevance 0.86
The effect of morphine (0.1 mg/kg) on insulin secretion stimulated by oral, intraduodenal, or intravenous administration of glucose was studied in seven healthy volunteers.
Regulation (effect) of Localization (secretion) of insulin associated with morphine
7) Confidence 0.62 Published 1986 Journal Diabetes Section Abstract Doc Link 3512343 Disease Relevance 0 Pain Relevance 0.40
Effect of naltrexone treatment on insulin secretion, insulin action and postprandial thermogenesis in obesity.
Regulation (Effect) of Localization (secretion) of insulin associated with obesity
8) Confidence 0.61 Published 1994 Journal Horm. Metab. Res. Section Title Doc Link 8082873 Disease Relevance 0.38 Pain Relevance 0.35
Moreover in obese patients we evaluated the effect of this anti-opioid drug on insulin secretion and insulin sensitivity during an IVGTT using the minimal model approach.
Regulation (effect) of Localization (secretion) of insulin associated with obesity and opioid
9) Confidence 0.61 Published 1994 Journal Horm. Metab. Res. Section Abstract Doc Link 8082873 Disease Relevance 0.41 Pain Relevance 0.37
On the basis of these results, it is hypothesized that endogenous PGE released in response to glucose stimulation exert an inhibiting effect on insulin release that becomes biphasic in appearance.
Regulation (effect) of Localization (release) of insulin
10) Confidence 0.61 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6419621 Disease Relevance 0 Pain Relevance 0
These studies were undertaken to evaluate in humans the possible physiological role of prostaglandins of the E series (PGE) in modulating insulin release and to assess whether endogenous PGE synthesis may account for the biphasic pattern of insulin secretion.
Spec (possible) Regulation (modulating) of Localization (release) of insulin
11) Confidence 0.61 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6419621 Disease Relevance 0 Pain Relevance 0
Clonidine effect on insulin secretion and lipolysis in man.
Regulation (effect) of Localization (secretion) of insulin associated with clonidine
12) Confidence 0.61 Published 1978 Journal Acta Diabetol Lat Section Title Doc Link 707001 Disease Relevance 0.42 Pain Relevance 0.72
The pancreatic beta-cell expresses an imidazoline-binding site that is involved in the regulation of insulin secretion.
Regulation (involved) of Localization (secretion) of insulin
13) Confidence 0.61 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028583 Disease Relevance 0 Pain Relevance 0
The regulation of insulin and glucagon secretion by opiates: a study with naloxone in healthy humans.
Regulation (regulation) of Localization (secretion) of insulin associated with narcan and opiate
14) Confidence 0.61 Published 1985 Journal Acta Diabetol Lat Section Title Doc Link 3890450 Disease Relevance 0 Pain Relevance 0.72
These data show low carbohydrate diets to be comparable or better than traditional low fat high carbohydrate diets for weight reduction, improvement in the dyslipidemia of diabetes and metabolic syndrome as well as control of blood pressure, postprandial glycemia and insulin secretion.
Regulation (control) of Localization (secretion) of insulin in fat associated with weight loss, diabetes mellitus and metabolic syndrome
15) Confidence 0.61 Published 2005 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC1188071 Disease Relevance 1.13 Pain Relevance 0
In control experiments benextramine by itself failed to affect insulin release from isolated islets.
Neg (failed) Regulation (affect) of Localization (release) of insulin
16) Confidence 0.59 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2575711 Disease Relevance 0 Pain Relevance 0.52
Ketamine hydrochloride's effect on glucose clearance-insulin secretion during intravenous glucose tolerance testing was studied in five African green monkeys.
Regulation (effect) of Localization (secretion) of insulin associated with ketamine, tolerance and impaired glucose tolerance
17) Confidence 0.50 Published 1985 Journal J. Med. Primatol. Section Abstract Doc Link 3889340 Disease Relevance 0.10 Pain Relevance 0.47
Hence, pancreas pieces of Bufo arenarum were incubated for 60 min at 25 degrees with 2 and 8 mM glucose plus the addition of hormones known to affect insulin secretion in mammals, measuring the release of insulin by radioimmunoassay.
Regulation (affect) of Localization (secretion) of insulin in pancreas
18) Confidence 0.46 Published 1998 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 9827019 Disease Relevance 0 Pain Relevance 0.11
Modulatory effect of hormones on insulin secretion in vitro in the toad.
Regulation (effect) of Localization (secretion) of insulin
19) Confidence 0.46 Published 1998 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Title Doc Link 9827019 Disease Relevance 0 Pain Relevance 0.16
Effects of opioid peptides and opiate alkaloids on insulin secretion in the rabbit.
Regulation (Effects) of Localization (secretion) of insulin associated with opiate and opioid
20) Confidence 0.46 Published 1983 Journal Endocrinology Section Title Doc Link 6339212 Disease Relevance 0 Pain Relevance 0.23

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