INT227405

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.87
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdc) nucleus (Pdc) cilium (Pdc)
cytoplasm (Pdc)
Anatomy Link Frequency
central cell 1
photoreceptors 1
epithelial cells 1
salivary duct 1
Pdc (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 44 95.28 Very High Very High Very High
tolerance 4 54.72 Quite High
pruritus 44 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Sicca syndrome 6 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
beta blocker 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Failure 18 98.92 Very High Very High Very High
Adhesions 1 98.88 Very High Very High Very High
Injury 16 97.20 Very High Very High Very High
Systemic Lupus Erythematosus 38 95.20 Very High Very High Very High
Disease Progression 12 94.72 High High
Retina Disease 36 89.68 High High
Usher Syndrome 36 87.00 High High
Apoptosis 13 85.28 High High
Biliary Liver Cirrhosis 300 83.04 Quite High
Disease 98 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have identified PDC as the central cell type which could secret a large amount of IFN-?
Localization (secret) of PDC in central cell
1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.31 Pain Relevance 0
It remains a mystery how PDC-E2 and other epitopes localized to the inner membrane of mitochondria become a targets of autoimmune injury in such highly selective biliary epithelial cells and salivary duct cells [84].
Localization (localized) of PDC in epithelial cells associated with injury
2) Confidence 0.15 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 0.93 Pain Relevance 0.07
Our original hypothesis stated that Clrn1 would be expressed in photoreceptors, and that the protein, CLRN1, would be targeted to rod photoreceptor synapses and contribute to synaptic adhesion and/or structure.
Localization (synapses) of rod photoreceptor in photoreceptors associated with adhesions
3) Confidence 0.07 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.69 Pain Relevance 0
It remains a mystery how PDC-E2 and other epitopes localized to the inner membrane of mitochondria become a targets of autoimmune injury in such highly selective biliary epithelial cells and salivary duct cells [84].
Localization (localized) of PDC in salivary duct associated with injury
4) Confidence 0.05 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 0.93 Pain Relevance 0.07

General Comments

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