INT227413

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 13.21
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DLAT) small molecule metabolic process (DLAT) transferase activity, transferring acyl groups (DLAT)
Anatomy Link Frequency
liver 3
rim 1
respiratory 1
DLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 557 99.16 Very High Very High Very High
Glutamate 72 98.22 Very High Very High Very High
imagery 20 97.56 Very High Very High Very High
fibrosis 122 96.32 Very High Very High Very High
Inflammation 177 95.80 Very High Very High Very High
Glutamate receptor 4 90.72 High High
medulla 10 88.00 High High
tolerance 106 83.00 Quite High
Inflammatory response 14 76.08 Quite High
Kinase C 7 75.32 Quite High
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 2322 100.00 Very High Very High Very High
Disease Progression 78 99.92 Very High Very High Very High
Autoimmune Disease 254 99.80 Very High Very High Very High
Cholangitis 29 99.70 Very High Very High Very High
Liver Disease 225 99.22 Very High Very High Very High
Nicotine Addiction 23 99.18 Very High Very High Very High
Sprains And Strains 18 98.52 Very High Very High Very High
Gallstones 185 98.24 Very High Very High Very High
Targeted Disruption 81 97.80 Very High Very High Very High
Fibrosis 128 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, the identified PDC-E2 residue was modified by replacing lipoic acid with a series of similar but distinct synthetic structures.
Gene_expression (residue) of PDC-E2
1) Confidence 0.44 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.79 Pain Relevance 0.07
Liver biopsy/histology A liver biopsy is not anymore regarded as mandatory for the diagnosis of PBC in patients with elevated serum markers of cholestasis and positive serum AMA [28, 29], but may be helpful in excluding other potential causes of cholestatic disease and in assessing disease activity and stage.
Gene_expression (diagnosis) of PBC in liver associated with biliary liver cirrhosis, disease and gallstones
2) Confidence 0.44 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.70 Pain Relevance 0.29
In two genetically manipulated mouse strains, spontaneous occurrence of a PBC-like lymphoid cholangitis together with positivity for anti-PDC-E2 within several weeks of life was reported when either transgenic expression of a dominant negative TGF-?
Gene_expression (positivity) of anti-PDC-E2 associated with targeted disruption, cholangitis, biliary liver cirrhosis and sprains and strains
3) Confidence 0.44 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.77 Pain Relevance 0.16
In PBC liver tissues, density of IL-17(+) CD4 lymphocytic infiltration (Th17) was higher than in healthy liver.
Gene_expression (tissues) of PBC in liver associated with biliary liver cirrhosis
4) Confidence 0.44 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.52 Pain Relevance 0.04
In a multi-variate Cox regression, the AE2 variant rs2303932 (T/A) was an independent prognostic factor for disease progression in PBC under UDCA treatment, in addition to serum bilirubin, alkaline phosphatase, and serum albumin levels which are established surrogate markers of prognosis in PBC [112].
Gene_expression (levels) of PBC associated with biliary liver cirrhosis and disease progression
5) Confidence 0.44 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.84 Pain Relevance 0.03
In PBC, expression of the hepatic AE2 and biliary bicarbonate secretion by AE2 are impaired [240, 241].
Gene_expression (expression) of PBC associated with biliary liver cirrhosis
6) Confidence 0.39 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.41 Pain Relevance 0.32
However, a causal link between altered miRNA expression and the development of PBC still remains unproven.


Gene_expression (expression) of PBC associated with biliary liver cirrhosis
7) Confidence 0.39 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.04 Pain Relevance 0
Smoking has been demonstrated to accelerate the progression of PBC and to be a risk factor for PBC [75,76], possibly due to exposure to chemicals in cigarette smoke.
Gene_expression (progression) of PBC associated with biliary liver cirrhosis and nicotine addiction
8) Confidence 0.34 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 1.26 Pain Relevance 0.03
Although rare findings in patients with PBC, "nuclear-rim" and "multiple nuclear-dot" patterns are highly specific for PBC irrespective of AMA status, and may provide supportive evidence for PBC especially in those who test AMA negative [33].
Gene_expression (specific) of PBC in rim associated with biliary liver cirrhosis
9) Confidence 0.34 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 1.92 Pain Relevance 0.07
All AMA negative patients with cholestatic liver disease should be carefully evaluated for the presence of PBC by cholangiography as well as liver biopsy.
Gene_expression (presence) of PBC in liver associated with liver disease and biliary liver cirrhosis
10) Confidence 0.34 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 0.97 Pain Relevance 0
AMA is negative in approximately 10% of patients who otherwise have all the features typical of PBC [20].
Neg (negative) Gene_expression (negative) of PBC associated with biliary liver cirrhosis
11) Confidence 0.30 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 0.86 Pain Relevance 0
By the targeted deletion of VGLUT2, we abolished the presynaptic release of glutamate and could show that this release was crucial to initiate the respiratory-related rhythm generation of the PBC.
Gene_expression (generation) of PBC in respiratory associated with glutamate
12) Confidence 0.02 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.14 Pain Relevance 0.18
To investigate rhythm generation from the PBC, medullar slices were prepared and analysed through calcium imaging and extracellular electrophysiological recordings.
Spec (investigate) Gene_expression (generation) of PBC associated with imagery
13) Confidence 0.02 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0 Pain Relevance 0.18

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