INT227414

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 5.14
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DLAT) small molecule metabolic process (DLAT) transferase activity, transferring acyl groups (DLAT)
Anatomy Link Frequency
liver 1
DLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 223 98.16 Very High Very High Very High
Inflammatory response 6 94.92 High High
tolerance 44 80.16 Quite High
pruritus 64 65.28 Quite High
fibrosis 48 61.32 Quite High
Inflammation 73 55.96 Quite High
beta blocker 2 32.64 Quite Low
corticosteroid 15 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 888 100.00 Very High Very High Very High
Liver Disease 85 100.00 Very High Very High Very High
Injury 35 98.64 Very High Very High Very High
Disease 161 94.68 High High
INFLAMMATION 73 94.56 High High
Gallstones 75 90.80 High High
Jaundice 14 89.04 High High
Targeted Disruption 9 87.92 High High
Cholangitis 11 80.48 Quite High
Sprains And Strains 7 78.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A role for IL-2 signaling defects in development of PBC was supported by a report of a PBC-like liver disease in a child with inborn deficiency of IL-2 receptor alpha [201].
Localization (disease) of PBC-like in liver associated with liver disease and biliary liver cirrhosis
1) Confidence 0.49 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.72 Pain Relevance 0.14
Why should the cause of PBC not be variable as is the clinical picture?
Localization (cause) of PBC associated with biliary liver cirrhosis
2) Confidence 0.49 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.20 Pain Relevance 0
It remains a mystery how PDC-E2 and other epitopes localized to the inner membrane of mitochondria become targets of autoimmune injury in PBC.
Localization (localized) of PDC-E2 associated with biliary liver cirrhosis and injury
3) Confidence 0.46 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.68 Pain Relevance 0.09
Therefore, it is important that current patients take this into account when they read outdated reports on PBC!
Localization (reports) of PBC associated with biliary liver cirrhosis
4) Confidence 0.37 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 1.55 Pain Relevance 0.03

General Comments

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