INT227415

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.93
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DLAT) small molecule metabolic process (DLAT) transferase activity, transferring acyl groups (DLAT)
DLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 30 98.96 Very High Very High Very High
Bile 156 92.56 High High
Inflammation 50 16.48 Low Low
pruritus 50 5.00 Very Low Very Low Very Low
fibrosis 34 5.00 Very Low Very Low Very Low
corticosteroid 11 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 642 100.00 Very High Very High Very High
Apoptosis 59 98.16 Very High Very High Very High
Disease 122 92.60 High High
Gallstones 52 90.88 High High
Acute Liver Failure 1 81.88 Quite High
Disease Progression 21 76.16 Quite High
Liver Disease 62 74.96 Quite High
Autoimmune Disease 71 74.88 Quite High
Systemic Lupus Erythematosus 12 64.76 Quite High
Diabetes Mellitus 3 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
showed differences in distribution between PBC and controls, confirming their potential role in the pathogenesis of PBC.
Regulation (role) of PBC associated with biliary liver cirrhosis
1) Confidence 0.29 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.08 Pain Relevance 0.04
This could solely support a role of apoptosis as a trigger for loss of self-tolerance, with probably only a little number of cells being affected rather than being the main initiating event in PBC.
Regulation (affected) of PBC associated with biliary liver cirrhosis, tolerance and apoptosis
2) Confidence 0.29 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.05 Pain Relevance 0.17
PDC is a member of the 2-oxo-acid dehydrogenase family of multi-enzyme complexes and is associated with both cellular and humoral immune responses in PBC.
Regulation (responses) of PBC associated with biliary liver cirrhosis
3) Confidence 0.13 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 0.80 Pain Relevance 0.07

General Comments

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