INT227416

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 13
Disease Relevance 17.02
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DLAT) small molecule metabolic process (DLAT) transferase activity, transferring acyl groups (DLAT)
Anatomy Link Frequency
lymph nodes 1
DLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 20 100.00 Very High Very High Very High
Inflammation 242 94.96 High High
pruritus 206 91.72 High High
tolerance 146 90.00 High High
corticosteroid 49 87.88 High High
Bile 736 86.88 High High
fluoxetine 10 71.04 Quite High
sSRI 20 69.96 Quite High
antagonist 36 63.00 Quite High
Serotonin 13 62.20 Quite High
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 2910 100.00 Very High Very High Very High
INFLAMMATION 242 100.00 Very High Very High Very High
Urinary Tract Infection 43 99.92 Very High Very High Very High
Bacterial Infection 10 99.92 Very High Very High Very High
Liver Disease 278 99.80 Very High Very High Very High
Autoimmune Disease 333 99.12 Very High Very High Very High
Autoimmune Hepatitis 59 98.16 Very High Very High Very High
Immunization 20 96.96 Very High Very High Very High
Systemic Lupus Erythematosus 52 96.24 Very High Very High Very High
Metabolic Bone Disease 30 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although attractive, the model of bacterial infections as cause of PBC is thus supported by little direct evidence.
Positive_regulation (cause) of PBC associated with biliary liver cirrhosis and bacterial infection
1) Confidence 0.45 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.91 Pain Relevance 0
Another microorganism that has been proposed as a candidate for the induction of PBC is Novosphingobium aromaticivorans [136].
Positive_regulation (induction) of PBC associated with biliary liver cirrhosis
2) Confidence 0.45 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.42 Pain Relevance 0.12
Recently, Novosphingobium aromaticivorans, a ubiquitous organism that metabolizes organic compounds and estrogens, has been proposed as a candidate for the induction of PBC [59].
Positive_regulation (induction) of PBC associated with biliary liver cirrhosis
3) Confidence 0.35 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 1.55 Pain Relevance 0.04
In favor of a bacterial etiology, recent data suggest that Toll-like receptor ligands induce an augmented inflammatory response in PBC.
Positive_regulation (augmented) of PBC associated with biliary liver cirrhosis and inflammatory response
4) Confidence 0.33 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.58 Pain Relevance 0.14
This small group of AMA-negative patients, however, may erroneously include patients with PBC-like symptoms induced by causes other than autoimmunity, such as patients with mutations in the ABCB4 (MDR3) gene [45].
Positive_regulation (induced) of PBC-like associated with biliary liver cirrhosis and autoimmune disease
5) Confidence 0.33 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.82 Pain Relevance 0.07
Xenobiotics, in studies of the same group, were also shown to induce PBC-like features in different animal models.
Positive_regulation (induce) of PBC-like associated with biliary liver cirrhosis
6) Confidence 0.33 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.76 Pain Relevance 0.08
Although an association of CTLA-4 variants and susceptibility to PBC could not be demonstrated in all studies [110, 111], Poupon et al. [112] most recently confirmed a potential role of TNF?
Positive_regulation (susceptibility) of PBC associated with biliary liver cirrhosis
7) Confidence 0.33 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.01 Pain Relevance 0.03
In PBC, it moderately increases absolute and relative fracture risk compared to the general population [315, 316].
Positive_regulation (increases) of PBC associated with biliary liver cirrhosis
8) Confidence 0.30 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.82 Pain Relevance 0.21
A significantly increased incidence of PBC is seen in relatives of PBC patients [89, 90].
Positive_regulation (increased) of PBC associated with biliary liver cirrhosis
9) Confidence 0.30 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.69 Pain Relevance 0.18
An alternative infectious agent has recently been proposed as trigger of PBC when a human retrovirus was identified both in liver tissue and hilar lymph nodes from PBC patients.
Positive_regulation (trigger) of PBC in lymph nodes associated with biliary liver cirrhosis
10) Confidence 0.30 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.90 Pain Relevance 0
Further objective data are warranted, obtained either from prospectively followed cohorts or through caseĀ–control epidemiological approaches, confirming a role for bacteria in triggering PBC [84].
Positive_regulation (triggering) of PBC associated with biliary liver cirrhosis
11) Confidence 0.30 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.89 Pain Relevance 0
Escherichia coli and their "rough" mutant have been reported in excess in the stools of patients with PBC; in addition, the incidence of urinary tract infections is high in PBC patients [57,58].
Positive_regulation (high) of PBC associated with biliary liver cirrhosis and urinary tract infection
12) Confidence 0.25 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 1.62 Pain Relevance 0.04
However, a small study of HLA typing in AMA positive and negative PBC indicated a lack of DR8 in those AMA negative cases [139].


Positive_regulation (positive) of PBC associated with biliary liver cirrhosis
13) Confidence 0.23 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 2.05 Pain Relevance 0.20

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