INT227424

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.61
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Prep (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 80 99.60 Very High Very High Very High
substance P 18 97.12 Very High Very High Very High
bradykinin 12 96.36 Very High Very High Very High
Pain 28 91.36 High High
tolerance 4 89.76 High High
rheumatoid arthritis 2 89.52 High High
Inflammation 34 85.20 High High
analgesia 8 79.68 Quite High
Spinal cord 2 77.04 Quite High
Glutamate 2 76.44 Quite High
Disease Link Frequency Relevance Heat
Pelvic Organ Prolapse 22 100.00 Very High Very High Very High
Syndrome 4 99.28 Very High Very High Very High
Recurrence 3 96.00 Very High Very High Very High
Pain 24 91.36 High High
Systemic Lupus Erythematosus 2 89.56 High High
Rheumatoid Arthritis 2 89.52 High High
Sprains And Strains 4 87.84 High High
Prolapse 13 85.36 High High
INFLAMMATION 38 85.20 High High
Osteoarthritis 2 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since MTX or MTX plus CsA increased POP activity but did not
POP Binding (activity) of associated with methotrexate
1) Confidence 0.35 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.59 Pain Relevance 0.95
Other links between POP and immunological
POP Binding (links) of
2) Confidence 0.30 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.96 Pain Relevance 0.36
Two other authors already earlier demonstrated that women with POP stage ?
POP Binding (women) of associated with pelvic organ prolapse
3) Confidence 0.09 Published 2010 Journal Int Urogynecol J Section Body Doc Link PMC2858280 Disease Relevance 0.51 Pain Relevance 0
NCM's were treated with adenovirus expressing dnMSTAT, MSTAT, or LacZ and then stressed with PE or media only.
PE Binding (stressed) of
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.55 Pain Relevance 0
Interestingly, in case of Ala-Ala (2d), Pro-Ala (2e) or Ala-Pro (2f) combinations, the in vitro half-lives were practically the same (around 20 min) that may imply that the affinity of POP to Pro is somewhat higher than to Ala, especially when Pro is the preceding amino acid.
POP Binding (affinity) of
5) Confidence 0.09 Published 2008 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2709471 Disease Relevance 0 Pain Relevance 0.08
Based on a combination of PEP and DOP, a commercial kit for single cell WGA was developed and used to amplify single human [20] and mouse cells (Wasserstrom, A. et al, submitted).
PEP Binding (combination) of
6) Confidence 0.04 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2266725 Disease Relevance 0 Pain Relevance 0

General Comments

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