INT227515

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.34
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtx1)
Anatomy Link Frequency
plasma 4
Mtx1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 438 100.00 Very High Very High Very High
cINOD 34 97.72 Very High Very High Very High
Pain 54 95.72 Very High Very High Very High
Inflammation 25 95.24 Very High Very High Very High
Arthritis 245 91.44 High High
substance P 9 81.20 Quite High
bradykinin 6 80.28 Quite High
headache 8 74.80 Quite High
cytokine 4 69.40 Quite High
chemokine 1 68.20 Quite High
Disease Link Frequency Relevance Heat
Chronic Disease 2 96.36 Very High Very High Very High
Pain 47 95.24 Very High Very High Very High
INFLAMMATION 31 95.24 Very High Very High Very High
Colon Cancer 1 93.52 High High
Testicular Cancer 1 92.32 High High
Nociception 10 91.92 High High
Juvenile Chronic Polyarthritis 199 91.44 High High
Bladder Cancer 1 91.08 High High
Malignant Neoplastic Disease 7 88.60 High High
Non-genital Cutaneous Warts 1 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no difference in the MTX dose or plasma MTX level between responders (15 cases) and nonresponders (seven cases) or between those with (15 cases) and without (seven cases) elevated serum transaminase levels.
Neg (no) Regulation (difference) of Gene_expression (dose) of MTX in plasma associated with methotrexate
1) Confidence 0.38 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.55 Pain Relevance 0.97
There was no difference in the MTX dose or plasma MTX level between responders (15 cases) and nonresponders (seven cases) or between those with (15 cases) and without (seven cases) elevated serum transaminase levels.
Neg (no) Regulation (difference) of Gene_expression (level) of MTX in plasma associated with methotrexate
2) Confidence 0.38 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.56 Pain Relevance 0.98
After controlling for MTX dose, subjects with higher proportions of MTXglu1+2??
Regulation (controlling) of Gene_expression (dose) of MTX associated with methotrexate
3) Confidence 0.31 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.18 Pain Relevance 0.34
MTX and CsA treatments affect the M?
Regulation (affect) of Gene_expression (treatments) of MTX associated with methotrexate
4) Confidence 0.20 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.74 Pain Relevance 0.69
mg plus MTX groups, respectively; RAPID 2: one patient in the CZP 400?
Regulation (respectively) of Gene_expression (groups) of MTX
5) Confidence 0.06 Published 2011 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC3021948 Disease Relevance 2.31 Pain Relevance 0.26

General Comments

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