INT227520

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 4.16
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa9) protein folding (Hspa9) mitochondrion (Hspa9)
enzyme binding (Hspa9) response to stress (Hspa9) cytoplasm (Hspa9)
Anatomy Link Frequency
muscle 4
Hspa9 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 174 99.22 Very High Very High Very High
Inflammatory stimuli 12 97.24 Very High Very High Very High
methotrexate 80 84.60 Quite High
Neuropeptide 4 34.48 Quite Low
substance P 18 30.08 Quite Low
Inflammatory mediators 4 28.32 Quite Low
cytokine 17 24.56 Low Low
Pain 27 5.00 Very Low Very Low Very Low
bradykinin 12 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 119 99.38 Very High Very High Very High
Myositis 168 99.28 Very High Very High Very High
INFLAMMATION 155 99.22 Very High Very High Very High
Cancer 69 98.60 Very High Very High Very High
Muscle Disease 4 96.32 Very High Very High Very High
Severe Combined Immunodeficiency 10 95.24 Very High Very High Very High
Teratoma 64 93.84 High High
Disease 31 92.48 High High
Muscular Dystrophy 4 89.76 High High
Apoptosis 5 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At variance with Grp94, Grp75 protein levels increased significantly in myositis biopsies with negligible levels of regeneration, and especially in those displaying a restricted sarcolemmal MHC-I immunoreactivity to a few clusters of myofibers [40].
Positive_regulation (increased) of Gene_expression (levels) of Grp75 protein associated with myositis
1) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.79 Pain Relevance 0.05
Conversely, levels of calreticulin and Grp75 increased about fourfold and twofold, respectively, in patient biopsies positive for sarcolemmal MHC-I immunoreactivity, compared with healthy subjects and patients negative for both inflammation and MHC-I labeling (P < 0.005).
Positive_regulation (increased) of Gene_expression (levels) of Grp75 associated with inflammation
2) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888201 Disease Relevance 0.82 Pain Relevance 0.19
Our data show that the two types of ER stress-response detectable in the presence of autoimmune myositis reveal the presence and the degree of muscle regeneration, by means of increased Grp94 levels, and reveal the influence of systemic stressing stimuli, probably of inflammatory origin, which are responsible for the increased expression of Grp75.
Positive_regulation (increased) of Gene_expression (expression) of Grp75 in muscle associated with stress, inflammation and myositis
3) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.90 Pain Relevance 0.11
These results indicate that, in myositis patients, muscle regeneration and inflammation, in addition to MHC-I upregulation, do evoke an ER stress-response characterized by the increased expression of Grp94 and Grp75, respectively.
Positive_regulation (increased) of Gene_expression (expression) of Grp75 in muscle associated with stress, inflammation and myositis
4) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888201 Disease Relevance 0.72 Pain Relevance 0.16
However, CsA
Positive_regulation (However) of Gene_expression (However) of CsA
5) Confidence 0.18 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.13
However, CsA
Positive_regulation (However) of Gene_expression (However) of CsA
6) Confidence 0.18 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.19
Immunosuppression with CsA did not augment the tumorigenicity of the cells in allogeneic mice.
Neg (not) Positive_regulation (augment) of Gene_expression (Immunosuppression) of CsA
7) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440803 Disease Relevance 0.93 Pain Relevance 0

General Comments

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