INT227521

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.25
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa9) protein folding (Hspa9) mitochondrion (Hspa9)
enzyme binding (Hspa9) response to stress (Hspa9) cytoplasm (Hspa9)
Anatomy Link Frequency
muscle 2
muscle fibers 2
Hspa9 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 40 99.90 Very High Very High Very High
Inflammation 87 99.74 Very High Very High Very High
Pain 13 95.40 Very High Very High Very High
substance P 9 80.88 Quite High
bradykinin 6 79.96 Quite High
cytokine 8 69.08 Quite High
chemokine 1 67.88 Quite High
Inflammatory mediators 2 66.12 Quite High
Inflammatory stimuli 6 26.56 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myositis 84 99.96 Very High Very High Very High
INFLAMMATION 77 99.62 Very High Very High Very High
Stress 59 98.28 Very High Very High Very High
Chronic Disease 1 96.04 Very High Very High Very High
Disease 14 92.48 High High
Nociception 10 91.92 High High
Cancer 3 70.56 Quite High
Injury 2 69.68 Quite High
Death 6 47.16 Quite Low
Necrosis 5 30.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was therefore to investigate the stress-response ongoing in muscle fibers of patients affected with inflammatory myopathies, focusing on Grp94, calreticulin and Grp75 expression and distribution.
Regulation (focusing) of Gene_expression (expression) of Grp75 in muscle fibers associated with stress and inflammation
1) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.61 Pain Relevance 0.12
Our data show that the two types of ER stress-response detectable in the presence of autoimmune myositis reveal the presence and the degree of muscle regeneration, by means of increased Grp94 levels, and reveal the influence of systemic stressing stimuli, probably of inflammatory origin, which are responsible for the increased expression of Grp75.
Regulation (responsible) of Gene_expression (expression) of Grp75 in muscle associated with stress, inflammation and myositis
2) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.91 Pain Relevance 0.11
MTX and CsA treatments affect the M?
Regulation (affect) of Gene_expression (treatments) of CsA associated with methotrexate
3) Confidence 0.16 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.74 Pain Relevance 0.69

General Comments

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