INT227522

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.85
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa9) protein folding (Hspa9) mitochondrion (Hspa9)
enzyme binding (Hspa9) response to stress (Hspa9) cytoplasm (Hspa9)
Anatomy Link Frequency
muscle 1
Hspa9 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 40 100.00 Very High Very High Very High
Inflammation 123 96.06 Very High Very High Very High
Osteoarthritis 60 90.00 High High
Arthritis 6 76.48 Quite High
endometriosis 64 50.00 Quite Low
Inflammatory stimuli 6 46.68 Quite Low
Pain 43 23.84 Low Low
cva 3 15.88 Low Low
cytokine 19 12.24 Low Low
Inflammatory response 3 11.52 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 114 96.06 Very High Very High Very High
Stress 59 92.40 High High
Cancer 4 90.68 High High
Knee Osteoarthritis 57 90.00 High High
Injury 2 89.80 High High
Nociception 10 85.48 High High
Myositis 84 82.32 Quite High
Arthritis 5 77.52 Quite High
Morbid Obesity 3 75.60 Quite High
Neurological Disease 3 60.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no change in strength or CSA of the uninvolved QFM in either group over the study period.
Neg (no) Regulation (change) of CSA
1) Confidence 0.39 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896350 Disease Relevance 0 Pain Relevance 0
This feature might affect the correct evaluation of the basal level of ER chaperone expression; the slightly higher values of Grp75 levels detected in Group 0 patients compared with those of Group III patients, however, would add even more relevance to the findings concerning patients of Groups I and II.


Regulation (values) of Grp75
2) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.89 Pain Relevance 0.11
We previously reported that systemic inflammation induced by a single LPS injection did not change Grp94 expression in rabbit adult skeletal myofibers [24] - we therefore applied the same experimental protocol to the mouse to investigate whether Grp75 and calreticulin levels were affected.
Spec (whether) Regulation (affected) of Grp75 associated with inflammation
3) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.31 Pain Relevance 0.12
Its effects on preoperative and postoperative QFM strength, QFM cross-sectional area (CSA), and clinical function in subjects undergoing TKA will be evaluated.


Regulation (effects) of CSA
4) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896350 Disease Relevance 0.38 Pain Relevance 0.16
We evaluated its effect on preoperative and postoperative isometric quadriceps femoris muscle (QFM) strength, QFM cross-sectional area (CSA) and clinical function (subjective and objective).
Regulation (effect) of CSA in muscle
5) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2896350 Disease Relevance 0.18 Pain Relevance 0.09
Log-transformed values were used for the statistical comparisons of CSA between control and TM-treated animals.
Regulation (control) of CSA
6) Confidence 0.14 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2569845 Disease Relevance 0 Pain Relevance 0
each group (treated and controls of MTX and/or CsA) after a gentle massage of the abdominal
Regulation (controls) of CsA associated with methotrexate
7) Confidence 0.10 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.09 Pain Relevance 0.18

General Comments

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