INT227524

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 7.69
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Anatomy Link Frequency
macrophages 8
tube 2
Prep (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 111 100.00 Very High Very High Very High
methotrexate 320 99.44 Very High Very High Very High
Inflammation 138 97.24 Very High Very High Very High
Hyperalgesia 24 96.68 Very High Very High Very High
substance P 72 96.16 Very High Very High Very High
rheumatoid arthritis 8 94.88 High High
cytokine 32 83.24 Quite High
bradykinin 48 78.92 Quite High
tolerance 16 72.32 Quite High
Analgesic 15 66.08 Quite High
Disease Link Frequency Relevance Heat
Stress 206 100.00 Very High Very High Very High
Pain 95 100.00 Very High Very High Very High
Pharyngitis 38 100.00 Very High Very High Very High
Pelvic Organ Prolapse 20 100.00 Very High Very High Very High
Hoarseness 9 100.00 Very High Very High Very High
Cough 8 100.00 Very High Very High Very High
INFLAMMATION 154 97.24 Very High Very High Very High
Nociception 80 97.08 Very High Very High Very High
Syndrome 17 96.72 Very High Very High Very High
Hyperalgesia 24 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Failure was assigned to postoperative POP-Q stage II or greater, i.e., its quantitation value was ?
Positive_regulation (postoperative) of Gene_expression (postoperative) of POP associated with pelvic organ prolapse
1) Confidence 0.48 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855447 Disease Relevance 1.27 Pain Relevance 0
1) treatments on dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP) activities and on algesic response in two distinct status of murine macrophages (M?
Positive_regulation (treatments) of Gene_expression (activities) of POP in macrophages
2) Confidence 0.47 Published 2008 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.22
1) treatments on dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP) activities and on algesic response in two distinct status of murine macrophages (M?
Positive_regulation (treatments) of Gene_expression (activities) of prolyl oligopeptidase in macrophages
3) Confidence 0.47 Published 2008 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.22
since POP activity in murine M?
Positive_regulation (since) of Gene_expression (activity) of POP
4) Confidence 0.47 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.24 Pain Relevance 0.58
DPPIV activity below a critical level, as observed here for POP activity of
Positive_regulation (observed) of Gene_expression (activity) of POP
5) Confidence 0.47 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.35 Pain Relevance 0.48
1) treatments on dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP) activities and on algesic response in two distinct status of murine macrophages (M?
Positive_regulation (dipeptidyl) of Gene_expression (activities) of POP in macrophages
6) Confidence 0.47 Published 2008 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.22
1) treatments on dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP) activities and on algesic response in two distinct status of murine macrophages (M?
Positive_regulation (dipeptidyl) of Gene_expression (activities) of prolyl oligopeptidase in macrophages
7) Confidence 0.47 Published 2008 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.22
disturbances were made when increased POP levels in synovial membrane
Positive_regulation (increased) of Gene_expression (levels) of POP
8) Confidence 0.41 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.99 Pain Relevance 0.38
DPPIV and POP activity levels with the in vivo excitability to thermal pain stimulus could highlight the in vivo role of these peptidases through their actions on those inflammatory and nociceptive mediators after their generation and release by M?
Positive_regulation (highlight) of Gene_expression (levels) of POP associated with nociception, pain and inflammation
9) Confidence 0.41 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.97 Pain Relevance 0.67
Therefore, it appears that myostatin upregulation following PE stress is Erk dependent.
Positive_regulation (upregulation) of Gene_expression (stress) of PE associated with stress
10) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 1.12 Pain Relevance 0
As shown in Figures 1A–D, PE stress did indeed activate Akt (and downstream GSK3- ?)
Positive_regulation (activate) of Gene_expression (stress) of PE associated with stress
11) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.37 Pain Relevance 0
These data indicate that myostatin is upregulated following PE stress.


Positive_regulation (upregulated) of Gene_expression (stress) of PE associated with stress
12) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.55 Pain Relevance 0
Between-group differences in the incidences of coughing during tracheal extubation, the presence of blood in the oropharyngeal secretions or on the tracheal tube after extubation, and POST, cough, and hoarseness for 24 h after the operation as well as differences in the severity scores for POST, cough, and hoarseness were analyzed using the ?
Positive_regulation (after) of Gene_expression (extubation) of POST in tube associated with hoarseness, pharyngitis and cough
13) Confidence 0.06 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872887 Disease Relevance 1.84 Pain Relevance 0.30

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