INT227549

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.32
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tshr) plasma membrane (Tshr) signal transducer activity (Tshr)
Anatomy Link Frequency
thyroid 2
Tshr (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 3 90.52 High High
fibrosis 9 82.40 Quite High
Inflammation 102 79.32 Quite High
corticosteroid 3 75.32 Quite High
cytokine 18 37.12 Quite Low
agonist 27 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 78 99.20 Very High Very High Very High
Autoimmune Disease 12 98.26 Very High Very High Very High
Graves' Ophthalmopathy 6 97.38 Very High Very High Very High
Eye Disease 189 96.70 Very High Very High Very High
Thyroid Disease 12 92.64 High High
Diplopia 3 91.84 High High
Optic Disorders 3 91.24 High High
Pain 3 90.52 High High
Disorders Of The Lacrimal System 3 90.28 High High
Pressure And Volume Under Development 6 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, TSH-R mRNA and protein are expressed widely in many tissues which are unaffected in GD, so the basis for the anatomical restriction of TED remains unclear [50, 66].
Gene_expression (expressed) of TSH-R mRNA associated with disease and eye disease
1) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266979 Disease Relevance 1.40 Pain Relevance 0
TED is closely associated with Graves' disease (GD), a common autoimmune disorder in which stimulatory autoantibodies against the thyroid-stimulating hormone receptor (TSH-R) cause the thyroid to produce excess thyroid hormone [50, 54, 58, 59].
Gene_expression (produce) of TSH-R in thyroid associated with autoimmune disease, graves' ophthalmopathy, disease and eye disease
2) Confidence 0.30 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266979 Disease Relevance 2.19 Pain Relevance 0.20
antibodies against self-antigen, such as the TSH-R [58].
Gene_expression (antibodies) of TSH-R
3) Confidence 0.30 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266979 Disease Relevance 0.72 Pain Relevance 0.04
A positive nuclear PER1 signal was also noted in other endocrine cell types (Figure S1A, arrowheads), including cells that contained growth hormone, prolactin, luteinising hormone or thyroid stimulating hormone (data not shown).
Gene_expression (contained) of thyroid stimulating hormone in thyroid
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002272 Disease Relevance 0 Pain Relevance 0

General Comments

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