INT227552

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.13
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
striated muscle 4
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 26 100.00 Very High Very High Very High
antagonist 6 99.84 Very High Very High Very High
Inflammation 136 93.44 High High
agonist 62 80.80 Quite High
COX2 22 70.24 Quite High
Neuropeptide 4 59.80 Quite High
Inflammatory response 9 59.76 Quite High
chemokine 4 48.88 Quite Low
Cholecystokinin 1 45.76 Quite Low
psoriasis 4 23.64 Low Low
Disease Link Frequency Relevance Heat
Adhesions 6 100.00 Very High Very High Very High
Cancer 149 98.56 Very High Very High Very High
Colorectal Cancer 26 98.52 Very High Very High Very High
Lung Cancer 44 96.32 Very High Very High Very High
INFLAMMATION 145 93.44 High High
Obesity 25 92.00 High High
Disease 54 90.80 High High
Skin Cancer 14 75.20 Quite High
Lewis Lung Carcinoma 1 74.68 Quite High
Apoptosis 21 72.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Statistically calculated mean expression levels of PPAR?
Regulation (calculated) of Phosphorylation (levels) of PPAR
1) Confidence 0.44 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.06 Pain Relevance 0
ligand-dependent sumoylation of PPAR?
Regulation (dependent) of Phosphorylation (sumoylation) of PPAR
2) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266979 Disease Relevance 0.39 Pain Relevance 0.12
evaluating the efficacy of PPAR?
Regulation (evaluating) of Phosphorylation (efficacy) of PPAR
3) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.29 Pain Relevance 0.16
The

physiological impact of the regulation of PPAR activity through phosphorylation

Regulation (regulation) of Phosphorylation (phosphorylation) of PPAR
4) Confidence 0.25 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.85 Pain Relevance 0.21
The role of these forms of PPAR?
Regulation (role) of Phosphorylation (forms) of PPAR
5) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.36 Pain Relevance 0.08
We found that genes that participate in multiple cellular activities such as focal adhesion, gap junction, hedgehog signaling pathway, Wnt signaling pathway, calcium signaling pathway, G protein signaling, striated muscle contraction, cell cycle, MAPK signaling pathway, mRNA processing binding reactome, cytokine-cytokine receptor interaction, adipocytokine signaling pathway, insulin signaling pathway, Jak-STAT signaling pathway, mTOR signaling pathway, regulation of actin cytoskeleton, inositol phosphate metabolism, glycan structures – biosynthesis, fatty acid biosynthesis, TGF-beta signaling pathway, PPAR signaling pathway, oxidative phosphorylation, folate biosynthesis, electron transport chain, aminoacyl-tRNA biosynthesis are differentially expressed upon arginine butyrate treatment clearly indicating HDAC inhibitory activity of butyrate [6].
Regulation (regulation) of Phosphorylation (phosphorylation) of PPAR in striated muscle associated with adhesions and cytokine
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0.09 Pain Relevance 0.17
We found that genes that participate in multiple cellular activities such as focal adhesion, gap junction, hedgehog signaling pathway, Wnt signaling pathway, calcium signaling pathway, G protein signaling, striated muscle contraction, cell cycle, MAPK signaling pathway, mRNA processing binding reactome, cytokine-cytokine receptor interaction, adipocytokine signaling pathway, insulin signaling pathway, Jak-STAT signaling pathway, mTOR signaling pathway, regulation of actin cytoskeleton, inositol phosphate metabolism, glycan structures – biosynthesis, fatty acid biosynthesis, TGF-beta signaling pathway, PPAR signaling pathway, oxidative phosphorylation, folate biosynthesis, electron transport chain, aminoacyl-tRNA biosynthesis are differentially expressed upon arginine butyrate treatment clearly indicating HDAC inhibitory activity of butyrate [6].
Regulation (participate) of Phosphorylation (phosphorylation) of PPAR in striated muscle associated with adhesions and cytokine
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0.10 Pain Relevance 0.17

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