INT2276

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Context Info
Confidence 0.61
First Reported 1975
Last Reported 2011
Negated 51
Speculated 22
Reported most in Abstract
Documents 234
Total Number 257
Disease Relevance 103.78
Pain Relevance 54.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 38
blood 13
body 7
liver 6
brain 5
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 452 100.00 Very High Very High Very High
agonist 359 100.00 Very High Very High Very High
anesthesia 171 100.00 Very High Very High Very High
Dopamine 109 100.00 Very High Very High Very High
narcan 105 100.00 Very High Very High Very High
antagonist 70 100.00 Very High Very High Very High
Clonidine 67 100.00 Very High Very High Very High
Opioid 60 100.00 Very High Very High Very High
Somatostatin 54 100.00 Very High Very High Very High
qutenza 52 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 2060 100.00 Very High Very High Very High
Insulin Resistance 758 100.00 Very High Very High Very High
Obesity 572 100.00 Very High Very High Very High
Body Weight 508 100.00 Very High Very High Very High
Impaired Glucose Tolerance 445 100.00 Very High Very High Very High
Hyperinsulinism 171 100.00 Very High Very High Very High
Hypoglycemia 64 100.00 Very High Very High Very High
Pancreatitis 26 100.00 Very High Very High Very High
Sprains And Strains 27 99.92 Very High Very High Very High
Appetite Loss 705 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The age of the rats (9-11 vs. 16-18 weeks) had no effect on the basal glucose or insulin levels, but older Wistar rats had a greater insulin output following oral glucose and older SH rats had a greater insulin output following intraperitoneal glucose.
Neg (no) Regulation (effect) of insulin associated with hypertension
1) Confidence 0.61 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12450062 Disease Relevance 1.14 Pain Relevance 0.41
However, clonidine did not affect pancreatic insulin and liver glycogen content of nondiabetic animals.
Neg (not) Regulation (affect) of insulin in liver associated with clonidine
2) Confidence 0.61 Published 1991 Journal Horm. Res. Section Abstract Doc Link 1814806 Disease Relevance 0.75 Pain Relevance 0.68
Morphine did not alter blood insulin levels during the light period, but markedly decreased it during the dark period independently of feeding.
Neg (not) Regulation (alter) of insulin in blood associated with morphine
3) Confidence 0.61 Published 1984 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6389947 Disease Relevance 0.09 Pain Relevance 0.59
Clonidine treatment significantly increased the weight gain, but did not affect plasma glucose, insulin, glucagon and norepinephrine in the diabetic animals.
Neg (not) Regulation (affect) of insulin in plasma associated with diabetes mellitus, weight gain and clonidine
4) Confidence 0.61 Published 1991 Journal Horm. Res. Section Abstract Doc Link 1814806 Disease Relevance 0.72 Pain Relevance 0.66
Effects of nicotine on body weight and plasma insulin in female and male rats.
Regulation (Effects) of insulin in plasma associated with anesthesia, body weight and nicotine
5) Confidence 0.61 Published 1994 Journal Life Sci. Section Title Doc Link 8057754 Disease Relevance 0.36 Pain Relevance 0.44
The sucrose solution did not affect insulin sensitivity in any group; however, urethan anesthesia did produce insulin resistance.
Neg (not) Regulation (affect) of insulin associated with anesthesia and insulin resistance
6) Confidence 0.61 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8203621 Disease Relevance 0.42 Pain Relevance 0.26
In addition, this study identified prior feeding history of rats (ad libitum feeding vs. overnight fasting) as an important variable relative to the study of naloxone's effects on glucose and insulin regulation during endotoxicosis.
Regulation (regulation) of insulin associated with narcan
7) Confidence 0.61 Published 1988 Journal Circ. Shock Section Abstract Doc Link 3061683 Disease Relevance 0.29 Pain Relevance 0.53
This study examined the effects of naloxone on glucose and insulin dyshomeostasis during endotoxicosis in ad libitum fed and overnight-fasted rats.
Spec (examined) Regulation (effects) of insulin associated with narcan
8) Confidence 0.61 Published 1988 Journal Circ. Shock Section Abstract Doc Link 3061683 Disease Relevance 0.13 Pain Relevance 0.27
Effects of naloxone on glucose and insulin regulation during endotoxicosis in fed and fasted rats.
Regulation (regulation) of insulin associated with narcan
9) Confidence 0.61 Published 1988 Journal Circ. Shock Section Title Doc Link 3061683 Disease Relevance 0.23 Pain Relevance 0.55
Moreover, they suggest that capsaicin-sensitive nerves could be involved in the regulation of insulin sensitivity.
Regulation (regulation) of insulin in nerves associated with qutenza
10) Confidence 0.60 Published 2005 Journal Life Sci. Section Abstract Doc Link 15939440 Disease Relevance 0.29 Pain Relevance 0.65
Ablation of capsaicin-sensitive afferent nerves affects insulin response during an intravenous glucose tolerance test.
Regulation (affects) of insulin in nerves associated with qutenza, tolerance and impaired glucose tolerance
11) Confidence 0.60 Published 2005 Journal Life Sci. Section Title Doc Link 15939440 Disease Relevance 0.37 Pain Relevance 0.77
Insulin sensitivity regulated by feeding in the conscious unrestrained rat.
Regulation (regulated) of Insulin associated with anesthesia
12) Confidence 0.60 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 11911229 Disease Relevance 0.21 Pain Relevance 0.18
Therefore the influences of the procedure on the plasma insulin, glucagon and glucose responses were studied in healthy rats and in rats with a tumour inoculated subcapsularly into the liver.
Regulation (responses) of insulin in liver associated with cancer
13) Confidence 0.60 Published 1990 Journal Br J Surg Section Abstract Doc Link 2187562 Disease Relevance 0.33 Pain Relevance 0.09
The effects of the fentanyl fluanisone combination (Hypnorm) and pentobarbitone sodium (Pentobarbital) anaesthesia on blood glucose, insulin and glucagon were tested in rats in the fed and fasted state.
Regulation (effects) of insulin in blood
14) Confidence 0.60 Published 1994 Journal Lab. Anim. Section Abstract Doc Link 7967463 Disease Relevance 0.05 Pain Relevance 0.03
Sham rats showed a dose-dependent inhibition of HGP by insulin, however (percentage 20-30 min of HGP/0-10 min of HGP for 0, 25, and 100 microU/ml insulin: 166 +/- 12, 125 +/- 7, and 101 +/- 5%, P less than 0.01), whereas CP rats showed no effect of insulin (130 +/- 6, 123 +/- 7, 134 +/- 7%, P = NS).
Neg (no) Regulation (effect) of insulin associated with chronic pancreatitis
15) Confidence 0.60 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2654478 Disease Relevance 0.70 Pain Relevance 0.66
In the diabetic CATO group, change in the fasting serum insulin levels was -0.083 ± 0.02 ng/ml (p<0.05) during the same feeding period, which was a 22% decrease from the initial level.
Regulation (change) of insulin associated with diabetes mellitus
16) Confidence 0.59 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788183 Disease Relevance 0.76 Pain Relevance 0
CONCLUSION: Endogenous opioids, possibly endorphin, may be important in the acute regulation of blood glucose, glucagon and insulin concentrations after haemorrhage.


Regulation (regulation) of insulin in blood
17) Confidence 0.58 Published 1994 Journal Eur J Surg Section Body Doc Link 7811825 Disease Relevance 0 Pain Relevance 0
Seven days of treatment with GJG did not affect the body weight and insulin levels throughout the experimental period.
Neg (not) Regulation (affect) of insulin in body associated with body weight
18) Confidence 0.58 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.77 Pain Relevance 0
The literature suggests that the lower levels of glucose and insulin and the attenuated insulin response to the glucose tolerance test are most likely a direct consequence of the drop in body weight [27].
Regulation (response) of insulin in body associated with body weight, tolerance and impaired glucose tolerance
19) Confidence 0.58 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2842885 Disease Relevance 0.77 Pain Relevance 0.09
These results strongly suggest that the gastroduodenal branch and hepatic branch proper, which merge to form the common hepatic branch, differentially interact with prevailing insulin levels to regulate hypothalamic and limbic neuropeptide mRNA expression.
Regulation (regulate) of insulin in gastroduodenal branch associated with neuropeptide
20) Confidence 0.56 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18638024 Disease Relevance 0.13 Pain Relevance 0.17

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