INT227601

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.54
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot7) cytoplasm (Acot7)
Anatomy Link Frequency
amacrine cells 3
retina 1
cerebral cortex 1
Acot7 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 8 99.68 Very High Very High Very High
Glutamate receptor 4 94.48 High High
Pyramidal cell 6 89.40 High High
gABA 16 72.64 Quite High
Neurotransmitter 22 71.16 Quite High
Dopamine 8 35.68 Quite Low
Enkephalin 12 34.08 Quite Low
agonist 20 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 136 96.40 Very High Very High Very High
Neuroblastoma 126 93.44 High High
Urological Neuroanatomy 7 92.40 High High
Disease 8 84.56 Quite High
Cirrhosis 19 51.76 Quite High
Ganglion Cysts 96 43.76 Quite Low
Liver Disease 8 35.24 Quite Low
Necrosis 2 26.88 Quite Low
Hepatic Encephalopathy 17 5.00 Very Low Very Low Very Low
Death 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Embryonic expression of mAChR2, mAChR3, and mAChR4 appear in non-overlapping laminae of the developing IPL at E9 [52], suggesting that these receptors may be expressed by different types of amacrine cells.
Gene_expression (expression) of ACh in amacrine cells
1) Confidence 0.75 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0 Pain Relevance 0.14
Further, in the postnatal chick retina, type-II cells may express mAChR4, whereas type-I cells do not [44,52], and these cells have different sensitivities to excitotoxins, suggesting that different types of glutamate receptors are expressed by these cells, and/or that they have different susceptibilities to large fluctuations in ion concentrations [4].
Gene_expression (express) of ACh in retina associated with glutamate receptor
2) Confidence 0.75 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0 Pain Relevance 0.15
Embryonic expression of mAChR2, mAChR3, and mAChR4 appear in non-overlapping laminae of the developing IPL at E9 [52], suggesting that these receptors may be expressed by different types of amacrine cells.
Gene_expression (expression) of ACh in amacrine cells
3) Confidence 0.75 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0 Pain Relevance 0.14
Embryonic expression of mAChR2, mAChR3, and mAChR4 appear in non-overlapping laminae of the developing IPL at E9 [52], suggesting that these receptors may be expressed by different types of amacrine cells.
Gene_expression (expression) of ACh in amacrine cells
4) Confidence 0.75 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0 Pain Relevance 0.14
Fig. 4AChE and ChAT detection in the cerebral cortex of control and experimental rats.
Gene_expression (detection) of ACh in cerebral cortex associated with cerebral cortex
5) Confidence 0.75 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.28 Pain Relevance 0.18
Twelve of the 23 genes from the SRD were present on these chips (AJAP1, NPHP4 KCNAB2, CHD5, RPL22, ICMT, ACOT7, HES2, TNFRSF25, KLHL21, THAP3, and CAMT1).
Gene_expression (present) of ACOT7
6) Confidence 0.43 Published 2008 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2483574 Disease Relevance 0.68 Pain Relevance 0
Expression of ICMT, THAP3, CAMTA1, ACOT7, KCNAB2, RPL22, and KLHL21 had weaker associations and/or associations with fewer variables (two to seven variables).
Gene_expression (Expression) of ACOT7
7) Confidence 0.43 Published 2008 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2483574 Disease Relevance 0.58 Pain Relevance 0

General Comments

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