INT227604

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.01
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
sympathetic 1
Chat (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 28 96.80 Very High Very High Very High
gABA 86 95.60 Very High Very High Very High
monoamine 8 91.04 High High
Glutamate 15 82.96 Quite High
Neurotransmitter 22 79.84 Quite High
Neuropeptide 15 53.76 Quite High
Nerve growth factor 58 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 44 5.00 Very Low Very Low Very Low
Spinal cord 41 5.00 Very Low Very Low Very Low
nociceptor 38 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 156 99.62 Very High Very High Very High
Targeted Disruption 100 99.04 Very High Very High Very High
Death 22 91.64 High High
Apoptosis 21 46.96 Quite Low
Umbilical Hernia 48 41.64 Quite Low
Cleft Palate 32 41.04 Quite Low
Ocular Toxicity (including Many Sub-types) 12 5.76 Low Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low
Respiratory Failure 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In VAChT knockout mice the amount of the ACh-synthesizing enzyme choline acetyltransferase (ChAT) is increased at the mRNA and protein levels compared to their wild-type littermates, suggesting that the change in ChAT expression may be related to a compensatory mechanism due to the lack of ACh release [16].
Transcription (mRNA) of choline acetyltransferase associated with targeted disruption
1) Confidence 0.52 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.28 Pain Relevance 0.53
In VAChT knockout mice the amount of the ACh-synthesizing enzyme choline acetyltransferase (ChAT) is increased at the mRNA and protein levels compared to their wild-type littermates, suggesting that the change in ChAT expression may be related to a compensatory mechanism due to the lack of ACh release [16].
Transcription (mRNA) of ChAT associated with targeted disruption
2) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.28 Pain Relevance 0.53
This has been confirmed in newborn ret mutant mice, which almost entirely lose the expression of ChAT and VAChT mRNAs in sympathetic ganglia.
Transcription (expression) of ChAT in sympathetic
3) Confidence 0.27 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0
The number of STG cells with strong expression of ChAT and VAChT mRNAs is reduced in mutant animals by more than 80%.
Transcription (expression) of ChAT associated with ganglion cysts
4) Confidence 0.27 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.27 Pain Relevance 0.03
Another possibility is that decreases in the abundance of ChAT/CRABP-positive cells in the IPL resulted from the down-regulation of ChAT and CRABP.
Transcription (abundance) of ChAT
5) Confidence 0.19 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.18 Pain Relevance 0

General Comments

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