INT22764

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Context Info
Confidence 0.64
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 81
Total Number 82
Disease Relevance 24.38
Pain Relevance 26.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 21
satellite cells 4
microglia 3
brain 2
skin 2
Ptger2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 532 100.00 Very High Very High Very High
COX2 358 100.00 Very High Very High Very High
Nerve growth factor 21 100.00 Very High Very High Very High
noradrenaline 6 100.00 Very High Very High Very High
addiction 5 99.92 Very High Very High Very High
diclofenac 1 99.82 Very High Very High Very High
dorsal root ganglion 146 99.76 Very High Very High Very High
Inflammation 580 99.68 Very High Very High Very High
Spinal cord 74 99.68 Very High Very High Very High
narcan 6 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 14 99.98 Very High Very High Very High
Wound Healing 7 99.84 Very High Very High Very High
Ganglion Cysts 164 99.76 Very High Very High Very High
INFLAMMATION 888 99.68 Very High Very High Very High
Osteoarthritis 82 99.52 Very High Very High Very High
Nociception 68 99.48 Very High Very High Very High
Cancer 30 98.88 Very High Very High Very High
Fever 126 98.76 Very High Very High Very High
Stress 90 98.52 Very High Very High Very High
Toxicity 23 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As stimulants, BK at 10(-5) M (n=9) and 10(-6) M (n=4) and BK in equimolar combination with histamine (HA) and serotonin (5-HT; 10(-5) M: n=8, 10(-6) M: n=6, 10(-7) M: n=6) dose-dependently increased PGE2 release.
Localization (release) of PGE2 associated with serotonin and bradykinin
1) Confidence 0.64 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627103 Disease Relevance 0.32 Pain Relevance 0.61
In marked contrast, with epidural analgesia, the inhibition of renal secretion of PGE2 is apparent.
Localization (secretion) of PGE2 associated with epidural and analgesia
2) Confidence 0.56 Published 1985 Journal Eur J Anaesthesiol Section Abstract Doc Link 3910429 Disease Relevance 0 Pain Relevance 0.39
The effects of epidural analgesia and conventional anaesthesia on renal excretion of PGE2 during orthopaedic surgery.
Localization (excretion) of PGE2 associated with anesthesia, epidural and analgesia
3) Confidence 0.56 Published 1985 Journal Eur J Anaesthesiol Section Title Doc Link 3910429 Disease Relevance 0 Pain Relevance 0.52
However, phosphate buffered SIF at pH 6.1 and 6.4 caused a substantial and significant decrease of the PGE2 release, probably due to low-pH block of phospholipases.
Localization (release) of PGE2
4) Confidence 0.56 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627103 Disease Relevance 0.24 Pain Relevance 0.56
Considering the total amount of PGE2 secreted the combination of inflammatory mediators caused a significantly greater release of PGE2 at 10(-5) and 10(-6) M (p<0.01, Kruskal-Wallis test) than BK stimulation alone.
Localization (release) of PGE2 associated with inflammatory mediators and bradykinin
5) Confidence 0.56 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627103 Disease Relevance 0.33 Pain Relevance 0.56
Rat skin, in vitro, is introduced as a novel model to measure basal and stimulated release of PGE2 and, in future, other substances relevant to nociception, such as neuropeptides.
Localization (release) of PGE2 in skin associated with nociception and neuropeptide
6) Confidence 0.56 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627103 Disease Relevance 0.15 Pain Relevance 0.26
Considering the total amount of PGE2 secreted the combination of inflammatory mediators caused a significantly greater release of PGE2 at 10(-5) and 10(-6) M (p<0.01, Kruskal-Wallis test) than BK stimulation alone.
Localization (secreted) of PGE2 associated with inflammatory mediators and bradykinin
7) Confidence 0.56 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627103 Disease Relevance 0.33 Pain Relevance 0.64
We further investigated whether the augmentation of COX-2 synthesis by NE in the presence of LPS is accompanied by an increased release of PGE2, an important product of the enzymatic activity of COX-2 (Fig. 3).
Localization (release) of PGE2
8) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0
This would suggest that enhanced secretion of PGE2 through NE might increase microglial toxicity.
Localization (secretion) of PGE2 associated with toxicity
9) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.59 Pain Relevance 0.18
NE increases release of PGE2 by LPS-stimulated primary microglial cells
Localization (release) of PGE2 in microglial cells
10) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0
The chemical mediator prostaglandin E2 (PGE2) is released during inflammation and sensitizes peripheral terminals of DRG neurons [35,36].
Localization (released) of PGE2 in PGE2 associated with dorsal root ganglion and inflammation
11) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 1.10 Pain Relevance 0.60
We observed a significant increase in the secretion of PGE2 after 8 h of stimulation with the combination of LPS (10 ng/ml) and NE (1 ?
Localization (secretion) of PGE2
12) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0
Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia

Background

Localization (secretion) of PGE2 in microglia
13) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Title Doc Link PMC2819253 Disease Relevance 0.15 Pain Relevance 0.32
Our study shows that NE increases LPS-induced COX-2 expression and PGE2 secretion by primary rat neonatal microglia in vitro.
Localization (secretion) of PGE2 in microglia
14) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.67 Pain Relevance 0.46
In normal rats, peptide perfusion did not change mucosal release of PGE2, TXB2 and LTB4.
Localization (release) of PGE2
15) Confidence 0.38 Published 1996 Journal Digestion Section Abstract Doc Link 8886582 Disease Relevance 0.75 Pain Relevance 0.26
The peptide did not further increase PGE2 and TXB2 release, but significantly stimulated LTB4 both on days 1 and 7 after induction of colitis.
Localization (release) of PGE2 associated with colitis
16) Confidence 0.38 Published 1996 Journal Digestion Section Abstract Doc Link 8886582 Disease Relevance 0.78 Pain Relevance 0.26
Treatment in vivo with the NSAID Na-diclofenac lowered PGE2 and IL-1 release and partly reversed the observed reduction of class I and II antigens.
Localization (release) of PGE2 in PGE2 associated with cinod and diclofenac
17) Confidence 0.29 Published 1990 Journal Agents Actions Section Abstract Doc Link 2327311 Disease Relevance 0.16 Pain Relevance 0.15
We conclude that NE affected stimulated PGE2 release via alpha2-adrenoceptors on cells other than cutaneous afferents while kappa-opioid receptors are expressed in peripheral terminals of cutaneous afferents and their activation reduced CGRP release and secondary PGE2 formation.
Localization (release) of PGE2 in PGE2 associated with kappa opioid receptor and calcitonin gene-related peptide
18) Confidence 0.28 Published 2001 Journal Neuroreport Section Abstract Doc Link 11447314 Disease Relevance 0 Pain Relevance 0.56
In contrast, selective kappa-opioid receptor activation diminished electrically evoked release of both CGRP and PGE2.
Localization (release) of PGE2 in PGE2 associated with kappa opioid receptor and calcitonin gene-related peptide
19) Confidence 0.28 Published 2001 Journal Neuroreport Section Abstract Doc Link 11447314 Disease Relevance 0 Pain Relevance 0.56
Nociception-evoked prostaglandin E2 (PGE2) release in the spinal cord contributes considerably to the development of hyperalgesia and allodynia.
Localization (release) of PGE2 in spinal cord associated with nociception, hyperalgesia, allodynia and spinal cord
20) Confidence 0.26 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16192391 Disease Relevance 0.58 Pain Relevance 0.35

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