INT227664

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF4E) translation (EIF4E) cytoplasm (EIF4E)
Anatomy Link Frequency
muscle 1
EIF4E (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
lidocaine 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 40 77.76 Quite High
Aging 46 73.24 Quite High
Muscular Atrophy 55 71.92 Quite High
Frailty 19 70.16 Quite High
Hypertrophy 1 69.68 Quite High
Injury 10 61.04 Quite High
Endometriosis (extended) 5 5.52 Low Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low
Hypertension 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another study, however, failed to detect any significant changes in the phosphorylation of Akt, mTOR, p70S6K, eEF2, eIF4E, and TSC2 in men following 10 and 21 d of ULS [26].
Phosphorylation (phosphorylation) of eIF4E
1) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.21 Pain Relevance 0
The differences in the anabolic response to feeding between the sexes, with men showing a significant increase and women no significant increase in MPS, was probably partially mediated by a lack of stimulation by feeding of protein translation initiation in female muscle, given that the feeding increased the phosphorylation of muscle eIF4ESer209 and eIF4E-BP1Thr37/46 in men but not in women.
Phosphorylation (phosphorylation) of eIF4E in muscle
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.08 Pain Relevance 0
Western analysis was used to measure the phosphorylation of Akt, p70s6k, eIF-4E, eIF4E-BP1, and eEF2.
Phosphorylation (phosphorylation) of eIF4E
3) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0 Pain Relevance 0
We found no differences between sexes in the extent of phosphorylation for components of the PKB/mTOR/p70s6k signaling pathway, or the phosphorylation of elements involved in the regulation of translation initiation (eIF4E and eIF4e-BP1) at baseline (fasted).
Phosphorylation (phosphorylation) of eIF4E
4) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.19 Pain Relevance 0
We found no differences between sexes in the extent of phosphorylation for components of the PKB/mTOR/p70s6k signaling pathway, or the phosphorylation of elements involved in the regulation of translation initiation (eIF4E and eIF4e-BP1) at baseline (fasted).
Phosphorylation (phosphorylation) of eIF4e
5) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.19 Pain Relevance 0
Feeding increased (P<0.05) AktThr308 and p70s6kThr389 phosphorylation to the same extent in men and women but increased (P<0.05) the phosphorylation of eIF4ESer209 and eIF4E-BP1Thr37/46 in men only.
Phosphorylation (phosphorylation) of eIF4E
6) Confidence 0.25 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2267222 Disease Relevance 0.07 Pain Relevance 0

General Comments

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