INT227668

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF4E) translation (EIF4E) cytoplasm (EIF4E)
Anatomy Link Frequency
muscle 2
EIF4E (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 16 78.32 Quite High
Aging 18 74.16 Quite High
Endometriosis (extended) 2 6.08 Low Low
Injury 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Testosterone Deficiency 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The differences in the anabolic response to feeding between the sexes, with men showing a significant increase and women no significant increase in MPS, was probably partially mediated by a lack of stimulation by feeding of protein translation initiation in female muscle, given that the feeding increased the phosphorylation of muscle eIF4ESer209 and eIF4E-BP1Thr37/46 in men but not in women.
Neg (not) Positive_regulation (increased) of Phosphorylation (phosphorylation) of eIF4E in muscle
1) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.08 Pain Relevance 0
Feeding increased (P<0.05) AktThr308 and p70s6kThr389 phosphorylation to the same extent in men and women but increased (P<0.05) the phosphorylation of eIF4ESer209 and eIF4E-BP1Thr37/46 in men only.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of eIF4E
2) Confidence 0.18 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2267222 Disease Relevance 0.07 Pain Relevance 0

General Comments

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