INT227668

Context Info Confidence 0.20 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.15 Pain Relevance 0

cytosol (EIF4E) translation (EIF4E) cytoplasm (EIF4E)

Anatomy Link Frequency muscle 2 EIF4E (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 4 5.00 lidocaine 2 5.00 cytokine 2 5.00 anesthesia 2 5.00 imagery 2 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 16 78.32 Aging 18 74.16 Endometriosis (extended) 2 6.08 Injury 4 5.00 INFLAMMATION 4 5.00 Hypertension 2 5.00 Hypoxia 2 5.00 Testosterone Deficiency 2 5.00 Body Weight 2 5.00 Frailty 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The differences in the anabolic response to feeding between the sexes, with men showing a significant increase and women no significant increase in MPS, was probably partially mediated by a lack of stimulation by feeding of protein translation initiation in female muscle, given that the feeding increased the phosphorylation of muscle eIF4ESer209 and eIF4E-BP1Thr37/46 in men but not in women.

Neg (not) Positive_regulation (increased) of Phosphorylation (phosphorylation) of eIF4E in muscle

1) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.08 Pain Relevance 0

Feeding increased (P<0.05) AktThr308 and p70s6kThr389 phosphorylation to the same extent in men and women but increased (P<0.05) the phosphorylation of eIF4ESer209 and eIF4E-BP1Thr37/46 in men only.

Positive_regulation (increased) of Phosphorylation (phosphorylation) of eIF4E

2) Confidence 0.18 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2267222 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.