INT227671

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bcl2l1) cytosol (Bcl2l1) mitochondrion (Bcl2l1)
growth (Bcl2l1) cytoskeleton (Bcl2l1) intracellular (Bcl2l1)
Anatomy Link Frequency
poly 1
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 99.22 Very High Very High Very High
methotrexate 1 98.28 Very High Very High Very High
Crohn's disease 1 67.68 Quite High
aspirin 13 53.24 Quite High
imagery 13 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 5 94.32 High High
Stomach Cancer 2 93.76 High High
Cancer 118 91.28 High High
Ovarian Cancer 33 76.56 Quite High
Disease 7 73.84 Quite High
Colon Cancer 5 71.84 Quite High
Inflammatory Bowel Disease 1 70.16 Quite High
Pancreatic Cancer 33 66.24 Quite High
Adenoma 1 64.80 Quite High
Congenital Anomalies 4 37.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antibodies for pEGFR (Tyr845, Tyr992), EGFR, pSTAT3 (Tyr705 and Ser727), poly-adenosine diphosphate ribose polymerase (PARP), cleaved caspases-3, Bcl-xL, and Bax were purchased from Cell Signaling Technology (Beverly, MA).
Protein_catabolism (cleaved) of Bcl-xL in poly associated with adenocard
1) Confidence 0.18 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 0.20 Pain Relevance 0.10
For example, REG4 expression seems to be responsible for cell resistance to anticancer drugs such as 5-fluouracil and methotrexate [15], [20], it promotes AKT phosphorylation and over-expression of the antiapoptotic proteins Bcl-2, Bcl-xL and survivin [21], [22], it activates the EGF receptor/Akt/AP1 signaling pathway [21] and its expression correlates with enhanced peritoneal metastasis in gastric carcinomas [22], [23].
Protein_catabolism (proteins) of Bcl-xL associated with methotrexate, stomach cancer and metastasis
2) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 0.75 Pain Relevance 0.08

General Comments

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