INT227698

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.88
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SSRP1) chromosome (SSRP1) nucleus (SSRP1)
DNA binding (SSRP1) cytoplasm (SSRP1)
Anatomy Link Frequency
A2780 2
SSRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 26 92.08 High High
aspirin 26 75.00 Quite High
cINOD 8 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 185 100.00 Very High Very High Very High
Weight Loss 2 99.92 Very High Very High Very High
Xerostomia 1 98.76 Very High Very High Very High
Disease 20 92.64 High High
Fatigue 3 88.48 High High
Diarrhoea 2 86.24 High High
Sleep Disorders 1 85.72 High High
Ovarian Cancer 67 74.16 Quite High
Renal Cancer 1 71.80 Quite High
Cognitive Disorder 4 68.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antiproliferative activity of cisplatin was not affected by 0.1 M HCl, however, oxoplatin exhibited a twofold enhanced cytotoxicity after preincubation under highly acidic conditions.
Neg (not) Regulation (affected) of cisplatin
1) Confidence 0.03 Published 2009 Journal Metal-Based Drugs Section Body Doc Link PMC2705772 Disease Relevance 0.33 Pain Relevance 0
FACT - (H&N-G) was found to be sensitive when total score was considered and statistical significant differences were found in 5 single items (questions 1, 5, 7, 10 and 11).


Regulation (sensitive) of FACT
2) Confidence 0.01 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2988779 Disease Relevance 1.11 Pain Relevance 0
Further, NCX-4040 significantly enhanced the sensitivity of A2780 cDDP cells (cisplatin alone, 80.6 ± 11.8% versus NCX-4040+cisplatin, 26.4 ± 7.6%; p < 0.01) and xenograft tumors (cisplatin alone, 74.0 ± 4.4% versus NCX-4040+cisplatin, 56.4 ± 7.8%; p < 0.05), to cisplatin treatment.
Regulation (sensitivity) of cisplatin in A2780 associated with cancer
3) Confidence 0.01 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2267444 Disease Relevance 0.69 Pain Relevance 0.12
Further, NCX-4040 significantly enhanced the sensitivity of A2780 cDDP cells (cisplatin alone, 80.6 ± 11.8% versus NCX-4040+cisplatin, 26.4 ± 7.6%; p < 0.01) and xenograft tumors (cisplatin alone, 74.0 ± 4.4% versus NCX-4040+cisplatin, 56.4 ± 7.8%; p < 0.05), to cisplatin treatment.
Regulation (sensitivity) of cisplatin in A2780 associated with cancer
4) Confidence 0.01 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2267444 Disease Relevance 0.76 Pain Relevance 0.12

General Comments

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