INT2277

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1978
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.15
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
stomach 2
neural 2
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 27 100.00 Very High Very High Very High
tetrodotoxin 6 99.82 Very High Very High Very High
lidocaine 2 98.64 Very High Very High Very High
qutenza 16 98.28 Very High Very High Very High
Endogenous opioid 16 97.12 Very High Very High Very High
Clonidine 2 86.24 High High
Bile 3 84.44 Quite High
opiate 2 82.48 Quite High
narcan 8 80.88 Quite High
peptic ulcer disease 1 45.20 Quite Low
Disease Link Frequency Relevance Heat
Duodenal Ulcer 2 78.04 Quite High
Disease 1 5.00 Very Low Very Low Very Low
Ulcers 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following removal of burimamide, 3 X 10(-6) M tetrodotoxin did not block gastrin stimulation of H+ secretion indicating that neural mechanisms are not required.
Negative_regulation (block) of Positive_regulation (stimulation) of gastrin in neural associated with tetrodotoxin
1) Confidence 0.58 Published 1978 Journal Experientia Section Abstract Doc Link 658248 Disease Relevance 0 Pain Relevance 0.17
DMPP caused lesser, though significant, increases in gastrin (166%) and somatostatin (83%) secretion that were nearly abolished by hexamethonium (84-91%) but were not significantly affected by atropine.
Negative_regulation (abolished) of Positive_regulation (increases) of gastrin associated with somatostatin
2) Confidence 0.58 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.48
Gastric acid inhibition after a single dose of PG was most pronounced in the first hour of a test meal and was accompanied by almost complete suppression of the meal-induced serum gastrin level.
Negative_regulation (suppression) of Positive_regulation (induced) of gastrin
3) Confidence 0.58 Published 1979 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 395627 Disease Relevance 0.15 Pain Relevance 0
At luminal pH 7 adrenergic blockade with phentolamine and propranolol reduced vagally stimulated gastrin by 60%.
Negative_regulation (reduced) of Positive_regulation (stimulated) of gastrin
4) Confidence 0.43 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.63
Atropine reduced vagally stimulated gastrin levels substantially.
Negative_regulation (reduced) of Positive_regulation (stimulated) of gastrin
5) Confidence 0.43 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.46
The increase of serum gastrin levels by luminal alkalization was significantly inhibited (50%) after administration of 4% lidocaine.
Negative_regulation (inhibited) of Positive_regulation (increase) of gastrin associated with lidocaine
6) Confidence 0.43 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.70
Vagal stimulation caused a decrease in perfusate pH and an increase of the intraluminal output of gastrin and somatostatin when the stomach was perfused with the dextrane solution pH 5.9.
Negative_regulation (decrease) of Positive_regulation (increase) of gastrin in stomach associated with somatostatin
7) Confidence 0.42 Published 1992 Journal Acta Physiol. Scand. Section Abstract Doc Link 1350163 Disease Relevance 0 Pain Relevance 0.41
Capsaicin administration inhibited the stimulated gastrin and histamine secretion and reversed the suppression of somatostatin secretion mediated by vagal stimulation.
Negative_regulation (inhibited) of Positive_regulation (stimulated) of gastrin
8) Confidence 0.39 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19296048 Disease Relevance 0 Pain Relevance 0
Tetrodotoxin and atropine sulfate completely inhibited this sodium taurocholate induced-gastrin increase, while truncal vagotomy was without effect.
Negative_regulation (inhibited) of Positive_regulation (increase) of induced-gastrin associated with tetrodotoxin
9) Confidence 0.38 Published 1995 Journal J. Gastroenterol. Section Abstract Doc Link 7719401 Disease Relevance 0 Pain Relevance 0.63
Both basal and acetylcholine-stimulated gastrin were inhibited by GLP-1 (7-36) amide but were not influenced by GLP-1 (1-36) amide.
Negative_regulation (inhibited) of Positive_regulation (acetylcholine-stimulated) of gastrin
10) Confidence 0.38 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 1972810 Disease Relevance 0 Pain Relevance 0.39

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox