INT227703

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.07
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F11) extracellular space (F11) extracellular region (F11)
plasma membrane (F11)
Anatomy Link Frequency
blood 1
tibia 1
neurons 1
patella 1
F11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuronal excitability 3 77.00 Quite High
Inflammation 17 71.04 Quite High
ischemia 4 63.92 Quite High
Pain 116 63.48 Quite High
ASIC 15 51.92 Quite High
IPN 7 51.12 Quite High
bradykinin 1 30.60 Quite Low
Serotonin 2 29.24 Quite Low
Nerve growth factor 4 28.76 Quite Low
Inflammatory mediators 1 27.40 Quite Low
Disease Link Frequency Relevance Heat
Facioscapulohumeral Muscular Dystrophy 75 96.56 Very High Very High Very High
Acidosis 14 87.12 High High
Shock 1 84.24 Quite High
INFLAMMATION 19 71.04 Quite High
Coronary Artery Disease 2 64.56 Quite High
Myalgia 1 63.48 Quite High
Pain 93 61.72 Quite High
Inflammatory Pain 7 51.12 Quite High
Hypersensitivity 1 50.00 Quite Low
Injury 7 26.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hyperosmolarity (600 mosmol kg-1 with mannitol) itself did not induce any detectable current (Figure 3A) but significantly potentiated the ASIC3 currents evoked by a pH reduction to 7.0 (Figure 3), an effect previously observed in rat DRG neurons or an ASIC3 expressing F-11 DRG cell line [8].
Gene_expression (expressing) of F-11 in neurons
1) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.74 Pain Relevance 0.43
In other words, either PTA-G or PTA-M is confounded by the neighboring bony mechanism.
Gene_expression (confounded) of PTA
2) Confidence 0.65 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2267450 Disease Relevance 0.06 Pain Relevance 0.06
The measurements of femoral rotation, tibial rotation, and femoral rotation relative to tibia, and patella tilt angle, PTA-G, PTA-S, and PTA-M were presented in Table 1.
Gene_expression (presented) of PTA in tibia
3) Confidence 0.58 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2267450 Disease Relevance 0 Pain Relevance 0
No DH sites were observed at two other proximal 4q35.2 genes, KLKB1 and F11, which encode proteins involved in blood coagulation.
Gene_expression (sites) of F11 in blood
4) Confidence 0.50 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.27 Pain Relevance 0
The measurements of femoral rotation, tibial rotation, and femoral rotation relative to tibia, and patella tilt angle, PTA-G, PTA-S, and PTA-M were presented in Table 1.
Gene_expression (presented) of PTA in patella
5) Confidence 0.20 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2267450 Disease Relevance 0 Pain Relevance 0

General Comments

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